Bioorthogonal Strategies for Engineering Extracellular Matrices

Ruthenium Complexes are pH-Activated Metallo Prodrugs (pHAMPs) with Light-Triggered Selective Toxicity Toward Cancer Cells

(2017) Fengrui Qu et al.   INORGANIC CHEMISTRY

Injectable dextran hydrogels fabricated by metal-free click chemistry for cartilage tissue engineering

(2017) Xiaoyu Wang et al.   Materials Science & Engineering C-Materials for Biological Applications

Photomediated oxime ligation as a bioorthogonal tool for spatiotemporally-controlled hydrogel formation and modification

(2017) Payam E. Farahani et al.   Journal of Materials Chemistry B

Bio-Orthogonally Crosslinked, Engineered Protein Hydrogels with Tunable Mechanics and Biochemistry for Cell Encapsulation

(2016) Christopher M. Madl et al.   ADVANCED FUNCTIONAL MATERIALS

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

(2016) Ester Jiménez-Moreno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

(2016) Weitao Jia et al.   BIOMATERIALS

Phototriggered fibril-like environments arbitrate cell escapes and migration from endothelial monolayers

(2016) Marcelo J. Salierno et al.   BIOMATERIALS

A simple method for enhancing the bioorthogonality of cyclooctyne reagent

(2016) He Tian et al.   CHEMICAL COMMUNICATIONS

Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor

(2016) Belén Rubio-Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation

(2016) Han Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Activated Staudinger–Bertozzi Ligation within Living Animals

(2016) Lisa Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

Supramolecular biomaterials

(2016) Matthew J. Webber et al.   NATURE MATERIALS

Click reactive microgels as a strategy towards chemically injectable hydrogels

(2016) Rémi Absil et al.   Polymer Chemistry

Programmable polyproteams built using twin peptide superglues

(2016) Gianluca Veggiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A

(2016) Hyun Ok Ham et al.   Nature Communications

Dual-Stage Crosslinking of a Gel-Phase Bioink Improves Cell Viability and Homogeneity for 3D Bioprinting

(2016) Karen Dubbin et al.   Advanced Healthcare Materials

Click-Crosslinked Injectable Gelatin Hydrogels

(2016) Sandeep T. Koshy et al.   Advanced Healthcare Materials

In situ-forming click-crosslinked gelatin based hydrogels for 3D culture of thymic epithelial cells

(2016) Vinh X. Truong et al.   Biomaterials Science

In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma

(2016) Jose M. Mejia Oneto et al.   ACS Central Science

Critical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water

(2015) Fumito Saito et al.   ACS Chemical Biology

Elastin-like recombinamer-covered stents: Towards a fully biocompatible and non-thrombogenic device for cardiovascular diseases

(2015) Israel González de Torre et al.   Acta Biomaterialia

Direct 3D Printing of Shear-Thinning Hydrogels into Self-Healing Hydrogels

(2015) Christopher B. Highley et al.   ADVANCED MATERIALS

Bioorthogonal Enzymatic Activation of Caged Compounds

(2015) Cornelia Ritter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

(2015) Joanna B. Pawlak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bioorthogonal Reaction ofN-Oxide and Boron Reagents

(2015) Justin Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Remodeling of Cell-Surface Sialic Acids through a Palladium-Triggered Bioorthogonal Elimination Reaction

(2015) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications

(2015) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular Guest–Host Interactions for the Preparation of Biomedical Materials

(2015) Christopher B. Rodell et al.   BIOCONJUGATE CHEMISTRY

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation

(2015) Elena Cambria et al.   BIOMACROMOLECULES

Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry

(2015) Rajiv M. Desai et al.   BIOMATERIALS

N -(furfural) chitosan hydrogels based on Diels–Alder cycloadditions and application as microspheres for controlled drug release

(2015) Marcelino Montiel-Herrera et al.   CARBOHYDRATE POLYMERS

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

(2015) Jungeun Bae et al.   CHEMICAL COMMUNICATIONS

In Vivo Targeting through Click Chemistry

(2015) Yevgeny Brudno et al.   ChemMedChem

Diels–Alder hydrogels with enhanced stability: First step toward controlled release of bevacizumab

(2015) Susanne Kirchhof et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ-Forming Hydrogels for Cell Encapsulation

(2015) Vinh X. Truong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium

(2015) Ann C. Gaffey et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Nitrile Oxide-Norbornene Cycloaddition as a Bioorthogonal Crosslinking Reaction for the Preparation of Hydrogels

(2015) Vinh X. Truong et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Biodegradable hyaluronic acid hydrogels to control release of dexamethasone through aqueous Diels–Alder chemistry for adipose tissue engineering

(2015) Ming Fan et al.   Materials Science & Engineering C-Materials for Biological Applications

Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord

(2015) T. Führmann et al.   METHODS

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

(2015) Siddharth S. Matikonda et al.   Chemical Science

Self-assembled hydrogels utilizing polymer–nanoparticle interactions

(2015) Eric A. Appel et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Synchronized cell attachment triggered by photo-activatable adhesive ligands allows QCM-based detection of early integrin binding

(2015) Jagoba Iturri et al.   Scientific Reports

Exploiting Electrostatic Interactions in Polymer–Nanoparticle Hydrogels

(2015) Eric A. Appel et al.   ACS Macro Letters

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Elastin-like recombinamer catalyst-free click gels: Characterization of poroelastic and intrinsic viscoelastic properties

(2014) Israel González de Torre et al.   Acta Biomaterialia

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3D Tissue Engineered Supramolecular Hydrogels for Controlled Chondrogenesis of Human Mesenchymal Stem Cells

(2014) Hyuntae Jung et al.   BIOMACROMOLECULES

Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model

(2014) Christopher D. Hermann et al.   BIOMATERIALS

Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

(2014) Yanjiao Jiang et al.   BIOMATERIALS

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

(2014) Xing Ma et al.   CHEMICAL REVIEWS

Avidity-controlled hydrogels for injectable co-delivery of induced pluripotent stem cell-derived endothelial cells and growth factors

(2014) Widya Mulyasasmita et al.   JOURNAL OF CONTROLLED RELEASE

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Supramolecular Host–Guest Carrier System for Growth Factors Employing VHH Fragments

(2014) Jordi Cabanas-Danés et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Diels–Alder crosslinked HA/PEG hydrogels with high elasticity and fatigue resistance for cell encapsulation and articular cartilage tissue repair

(2014) Feng Yu et al.   Polymer Chemistry

Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry

(2014) F. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

(2014) Ampofo Darko et al.   Chemical Science

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

(2014) Jason T. Weiss et al.   Nature Communications

Interfacial Bioorthogonal Cross-Linking

(2014) Han Zhang et al.   ACS Macro Letters

Supramolecular Hydrogels for Long-Term Bioengineered Stem Cell Therapy

(2014) Junseok Yeom et al.   Advanced Healthcare Materials

Photopatterning of Multifunctional Hydrogels to Direct Adult Neural Precursor Cells

(2014) Mikhail V. Tsurkan et al.   Advanced Healthcare Materials

Dynamic cell-adhesive microenvironments and their effect on myogenic differentiation

(2013) Simone Weis et al.   Acta Biomaterialia

Photo-Activatable Surfaces for Cell Migration Assays

(2013) Marcelo J. Salierno et al.   ADVANCED FUNCTIONAL MATERIALS

Preorganized Hydrogel: Self-Healing Properties of Supramolecular Hydrogels Formed by Polymerization of Host-Guest-Monomers that Contain Cyclodextrins and Hydrophobic Guest Groups

(2013) Takahiro Kakuta et al.   ADVANCED MATERIALS

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Display of Bioactivity through Host-Guest Chemistry

(2013) Job Boekhoven et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile and Stabile Linkages through Tyrosine: Bioconjugation Strategies with the Tyrosine-Click Reaction

(2013) Hitoshi Ban et al.   BIOCONJUGATE CHEMISTRY

In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry

(2013) Yaping Fan et al.   BIOMACROMOLECULES

Diels–Alder Mediated Controlled Release from a Poly(ethylene glycol) Based Hydrogel

(2013) Kenneth Christopher Koehler et al.   BIOMACROMOLECULES

Rational Design of Network Properties in Guest–Host Assembled and Shear-Thinning Hyaluronic Acid Hydrogels

(2013) Christopher B. Rodell et al.   BIOMACROMOLECULES

Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine–Norbornene Chemistry

(2013) Daniel L. Alge et al.   BIOMACROMOLECULES

In Situ Cross-Linkable Hydrogel of Hyaluronan Produced via Copper-Free Click Chemistry

(2013) Akira Takahashi et al.   BIOMACROMOLECULES

A Diels–Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells

(2013) Kenneth C. Koehler et al.   BIOMATERIALS

An interpenetrating HA/G/CS biomimic hydrogel via Diels–Alder click chemistry for cartilage tissue engineering

(2013) Feng Yu et al.   CARBOHYDRATE POLYMERS

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Supramolecular control of cell adhesion via ferrocene–cucurbit[7]uril host–guest binding on gold surfaces

(2013) Pauline Neirynck et al.   CHEMICAL COMMUNICATIONS

Expanding room for tetrazine ligations in the in vivo chemistry toolbox

(2013) Jolita Šečkutė et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Linear versus Dendritic Molecular Binders for Hydrogel Network Formation with Clay Nanosheets: Studies with ABA Triblock Copolyethers Carrying Guanidinium Ion Pendants

(2013) Shingo Tamesue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyaluronic Acid Click Hydrogels Emulate the Extracellular Matrix

(2013) Shawn C. Owen et al.   LANGMUIR

Dextran-Based Self-Healing Hydrogels Formed by Reversible Diels-Alder Reaction under Physiological Conditions

(2013) Zhao Wei et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

(2013) Vinh X. Truong et al.   Biomaterials Science

Investigation of the Diels–Alder reaction as a cross-linking mechanism for degradable poly(ethylene glycol) based hydrogels

(2013) Susanne Kirchhof et al.   Journal of Materials Chemistry B

Dynamically crosslinked materials via recognition of amino acids by cucurbit[8]uril

(2013) Matthew J. Rowland et al.   Journal of Materials Chemistry B

In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering

(2012) Kyeng Min Park et al.   ACS Nano

Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells

(2012) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Smart Self-Assembled Hybrid Hydrogel Biomaterials

(2012) Jindřich Kopeček et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Supramolecular System for the Electrochemically Controlled Release of Cells

(2012) Qi An et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,2,3-Triazole–Heme Interactions in Cytochrome P450: Functionally Competent Triazole–Water–Heme Complexes

(2012) Kip P. Conner et al.   BIOCHEMISTRY

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition

(2012) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Tetrakis(hydroxymethyl) Phosphonium Chloride as a Covalent Cross-Linking Agent for Cell Encapsulation within Protein-Based Hydrogels

(2012) Cindy Chung et al.   BIOMACROMOLECULES

Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture

(2012) Hang Lin et al.   BIOMATERIALS

Reductive alkylation of hyaluronic acid for the synthesis of biocompatible hydrogels by click chemistry

(2012) Gloria Huerta-Angeles et al.   CARBOHYDRATE POLYMERS

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

(2012) Petr Klán et al.   CHEMICAL REVIEWS

(Ultra)Fast Catalyst-Free Macromolecular Conjugation in Aqueous Environment at Ambient Temperature

(2012) Mathias Glassner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reversible and Oriented Immobilization of Ferrocene-Modified Proteins

(2012) Lanti Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrahigh-Water-Content Supramolecular Hydrogels Exhibiting Multistimuli Responsiveness

(2012) Eric A. Appel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Injectable Solid Peptide Hydrogel as a Cell Carrier: Effects of Shear Flow on Hydrogels and Cell Payload

(2012) Congqi Yan et al.   LANGMUIR

Supramolecularly Oriented Immobilization of Proteins Using Cucurbit[8]uril

(2012) Arántzazu González-Campo et al.   LANGMUIR

Selective esterase-ester pair for targeting small molecules with cellular specificity

(2012) L. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Counting primary loops in polymer gels

(2012) H. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Moving from static to dynamic complexity in hydrogel design

(2012) Jason A. Burdick et al.   Nature Communications

Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

(2012) Jukuan Zheng et al.   ACS Macro Letters

Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds

(2012) Malar A. Azagarsamy et al.   ACS Macro Letters

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

(2011) Cole A. DeForest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of the Matrix Microenvironment for Stem Cell Engineering and Regenerative Medicine

(2011) Ngan F. Huang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Regenerative Biomaterials that “Click”: Simple, Aqueous-Based Protocols for Hydrogel Synthesis, Surface Immobilization, and 3D Patterning

(2011) Chelsea M. Nimmo et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

(2011) Chelsea M. Nimmo et al.   BIOMACROMOLECULES

Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)

(2011) James McNulty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Covalent stabilization of alginate hydrogel beads via Staudinger ligation: Assessment of poly(ethylene glycol) and alginate cross-linkers

(2011) Kerim M. Gattás-Asfura et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Light-Induced Hetero-Diels−Alder Cycloaddition: A Facile and Selective Photoclick Reaction

(2011) Selvanathan Arumugam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine–trans-Cyclooctene Ligation

(2011) Michael T. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide Separation through a CB[8]-Mediated Supramolecular Trap-and-Release Process†

(2011) Feng Tian et al.   LANGMUIR

Direct Synthesis of Biodegradable Polysaccharide Derivative Hydrogels Through Aqueous Diels-Alder Chemistry

(2011) Huaping Tan et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers

(2011) Brian A. Aguado et al.   TISSUE ENGINEERING PART A

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Endothelial Cell Guidance in 3D Patterned Scaffolds

(2010) Yukie Aizawa et al.   ADVANCED MATERIALS

Protein Modification by Strain-Promoted Alkyne-Nitrone Cycloaddition

(2010) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Surface Functionalization Using Catalyst-Free Azide−Alkyne Cycloaddition

(2010) Alexander Kuzmin et al.   BIOCONJUGATE CHEMISTRY

The use of vascular endothelial growth factor functionalized agarose to guide pluripotent stem cell aggregates toward blood progenitor cells

(2010) Nafees Rahman et al.   BIOMATERIALS

Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels

(2010) Sudhir Khetan et al.   BIOMATERIALS

Ruthenium-based chemotherapeutics: are they ready for prime time?

(2010) Emmanuel S. Antonarakis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture

(2010) Cole A. DeForest et al.   CHEMISTRY OF MATERIALS

Characterisation of N-vinyl-2-pyrrolidone-based hydrogels prepared by a Diels–Alder click reaction in water

(2010) Hong-Liang Wei et al.   EUROPEAN POLYMER JOURNAL

Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

(2010) Hitoshi Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supramolecular Cross-Linked NetworksviaHost−Guest Complexation with Cucurbit[8]uril

(2010) Eric A. Appel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder

(2010) Qigang Wang et al.   NATURE

Development of Biomedical Polymer-Silicate Nanocomposites: A Materials Science Perspective

(2010) Chia-Jung Wu et al.   Materials

Chemoselective Cross-Linking and Functionalization of Alginate via Staudinger Ligation

(2009) Kerim M. Gattás-Asfura et al.   BIOMACROMOLECULES

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

(2009) Craig S. McKay et al.   CHEMICAL COMMUNICATIONS

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Room Temperature Dynamic Polymers Based on Diels-Alder Chemistry

(2009) P. Reutenauer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells

(2009) Rüdiger Pipkorn et al.   JOURNAL OF PEPTIDE SCIENCE

Selective Labeling of Living Cells by a Photo-Triggered Click Reaction

(2009) Andrei A. Poloukhtine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silicate Cross-Linked Bio-Nanocomposite Hydrogels from PEO and Chitosan

(2009) Qu Jin et al.   MACROMOLECULAR BIOSCIENCE

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Copper-Free “Click” Modification of DNA via Nitrile Oxide−Norbornene 1,3-Dipolar Cycloaddition

(2009) Katrin Gutsmiedl et al.   ORGANIC LETTERS

Thermosensitive hydrogels synthesized by fast Diels–Alder reaction in water

(2009) Hong-Liang Wei et al.   POLYMER

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Sequential crosslinking to control cellular spreading in 3-dimensional hydrogels

(2009) Sudhir Khetan et al.   Soft Matter

A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins

(2008) Wenjiao Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocontrolled Cell Adhesion on a Surface Functionalized with a Caged Arginine-Glycine-Aspartate Peptide

(2008) Yuki Ohmuro-Matsuyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides

(2008) Svea Petersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Three-dimensional Chemical Patterning of Transparent Hydrogels

(2008) Jordan H. Wosnick et al.   CHEMISTRY OF MATERIALS

Nanocomposite polymer hydrogels

(2008) Patrick Schexnailder et al.   COLLOID AND POLYMER SCIENCE

Cytocompatibility studies of anin situphotopolymerized thermoresponsive hydrogel nanoparticle system using human aortic smooth muscle cells

(2008) Abhimanyu Sabnis et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Photochemical Synthesis of Functionalizedtrans-Cyclooctenes Driven by Metal Complexation

(2008) Maksim Royzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembling Hydrogels Based on β-Cyclodextrin/Cholesterol Inclusion Complexes

(2008) Frank van de Manakker et al.   MACROMOLECULES

Formation of Physical Hydrogels via Host−Guest Interactions of β-Cyclodextrin Polymers and Copolymers Bearing Adamantyl Groups

(2008) Carsten Koopmans et al.   MACROMOLECULES

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

Independent tuning of multiple biomaterial properties using protein engineering

(2008) Karin S. Straley et al.   Soft Matter