Review
Biochemistry & Molecular Biology
Chendruru Geya Sree, Viswanath Buddolla, Buddolla Anantha Lakshmi, Young Joon Kim
Summary: Phthalates are widely used plasticizers in polymer products, with increasing exposure to people worldwide, causing health concerns. They are commonly used as excipients in controlled-release capsules and enteric coatings, posing risks to patients taking these drugs. Phthalates are primarily responsible for testicular dysfunction, ovarian toxicity, and reduced steroidogenesis in both animals and humans. More research is needed to better understand the health concerns related to phthalates and their metabolites, including investigating their various forms and biomedical effects in different tissues or organs. This review summarizes the chemical interactions, mechanisms, and biomedical applications of phthalates in animals and humans.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yanjiao Zhang, Xinyi Fang, Jiahua Wei, Runyu Miao, Haoran Wu, Kaile Ma, Jiaxing Tian
Summary: PDX-1 plays a crucial role in pancreatic development and the pathogenesis of diabetes. Overexpression of PDX-1 regulates pancreatic development and promotes beta-cell differentiation and insulin secretion. The absence of PDX-1 increases susceptibility to diabetes.
Review
Pharmacology & Pharmacy
Sapna Sedha, Hoomin Lee, Siddhartha Singh, Sunil Kumar, Subodh Jain, Ajaz Ahmad, Yousef A. Bin Jardan, Sonam Sonwal, Shruti Shukla, Jesus Simal-Gandara, Jianbo Xiao, Yun Suk Huh, Young-Kyu Han, Vivek K. Bajpai
Summary: Phthalates, pervasive compounds widely used in various products, have been linked to developmental and reproductive toxicity, highlighting the importance of developing non-toxic alternatives to reduce risks of exposure. More epidemiological studies are needed to further understand the impact of phthalates on human health.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Jiangman Liu, Guangping Lang, Jingshan Shi
Summary: Type 2 diabetes mellitus is a metabolic disease characterized by high blood sugar levels due to insulin deficiency or resistance. Various environmental factors, age, and global epigenetic changes may contribute to its development. Research is focusing on restoring beta-cell numbers or function to reverse the metabolic consequences of insulin deficiency in diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Environmental Sciences
Lu Kong, Yongya Wu, Wangcheng Hu, Lin Liu, Yuying Xue, Geyu Liang
Summary: The study revealed that piR-mmu-32362259 may affect the occurrence and development of injury in mouse spermatogenesis process by regulating the PI3K-AKT signaling pathway. Transfecting GC-1 cells with low-expression lentivirus of piR-mmu-32362259 showed significant effects, indicating the important role of piR-mmu-32362259 in alleviating Ni NPs-induced damage in GC-1 cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Ana C. Quevedo, Iseult Lynch, Eugenia Valsami-Jones
Summary: Cell death is a crucial process in maintaining cell homeostasis, and silver nanoparticles (AgNPs) have been shown to induce cell death by disrupting cellular signaling functions. This study used embryonic zebrafish cells as a model to investigate the mechanisms involved in AgNPs and Ag+ toxicity, with different sizes and concentrations of AgNPs and Ag+ being tested. The results indicated that exposure dose and physicochemical properties of AgNPs played a significant role in regulating various cell death modalities and signaling pathways in response to induced damage.
Article
Environmental Sciences
M. K. Dziobak, R. S. Wells, E. C. Pisarski, E. F. Wirth, L. B. Hart
Summary: This study evaluated exposure to phthalate metabolites in free-ranging bottlenose dolphins, finding that approximately 75% of the dolphins had detectable concentrations of at least one phthalate metabolite. Sex and age did not significantly affect the detection and concentration of phthalate metabolites.
Article
Food Science & Technology
Yangyang Ding, Tong Xu, Guanghua Mao, Yao Chen, Xuchun Qiu, Liuqing Yang, Ting Zhao, Xiaoxiao Xu, Weiwei Feng, Xiangyang Wu
Summary: Our study revealed that female P-T2DM mice tend to suffer from increased DEHP-induced metabolic toxicity compared with normal mice and male P-T2DM mice, primarily attributed to hepatotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Ruoru Yang, Jianheng Zheng, Jin Qin, Shaojie Liu, Xinyuan Liu, Yiying Gu, Shuyu Yang, Jun Du, Shuguang Li, Bo Chen, Ruihua Dong
Summary: In this study, the effects of DBP on insulin synthesis and secretion were investigated using an in vitro culture system of rat insulinoma (INS-1) cells. The results showed that DBP significantly decreased insulin synthesis and secretion in INS-1 cells, and caused apoptosis and mitochondrial dysfunction through the mitochondrial apoptotic pathway and oxidative stress. These findings suggest that interference with these two pathways could be considered in the development of preventive protection measures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Ida Pastore, Emma Assi, Moufida Ben Nasr, Andrea Mario Bolla, Anna Maestroni, Vera Usuelli, Cristian Loretelli, Andy Joe Seelam, Ahmed Abdelsalam, Gian Vincenzo Zuccotti, Francesca D'Addio, Paolo Fiorina
Summary: Although progress has been made in understanding the pathophysiological mechanisms of T1D, the quest for effective therapeutic options is ongoing. Promising results have been seen with HSC-based approaches and teplizumab, but more research is needed to establish their long-term efficacy and safety. Genetically engineered HSCs hold potential as a novel biologic therapy for T1D and other autoimmune/immune-related disorders, with studies in murine models and humanized mouse models showing accelerated translational potentials.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stephen T. O'Brien, Orla M. Neylon, Timothy O'Brien
Summary: Cardiovascular disease is the leading cause of death in Type 1 Diabetes, with the molecular basis for atherosclerosis heavily influenced by hyperglycaemia. Current tools for assessing CVD risk in Type 1 Diabetes patients are limited, posing challenges for selecting appropriate lipid-lowering therapies. Best practice guidance for managing dyslipidaemia in Type 1 Diabetes is mainly based on evidence from Type 2 Diabetes patients and expert opinions.
Article
Environmental Sciences
Randall Jenkins, Devlynne Ondusko, Luke Montrose, Ryan Forbush, David Rozansky
Summary: The study shows that in a neonatal unit, infants receive 98% of DEHP exposure from respiratory devices, with bubble CPAP accounting for 95% of the total exposure. By avoiding the use of IV tubing containing DEHP and modifying respiratory equipment appropriately, DEHP exposure can be significantly reduced.
Article
Oncology
Diyi Zhou, Lijun Chen, Xin Mou
Summary: Acarbose can promote the proliferation of islet beta cells and inhibit PDX-1 methylation in diabetic mice, providing a new strategy for treating T2DM.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Agriculture, Multidisciplinary
Jia Yu, Haoyang Zou, Tiehua Zhang, Jie Zhang
Summary: This review examines the molecular mechanisms by which non-phthalate plasticizers modulate nuclear receptor activity, emphasizing the importance of evaluating their endocrine-disrupting effects and laying the foundation for the development of safer alternatives within the plastic industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Lang Lang, Angjin Yang, Langxi Lang, Yuanyuan Hu, Pan Xu, Lei Yu, Wenlan Li
Summary: This study found that the reproductive toxicity of Benzyl butyl phthalate (BBP) was directly related to its metabolites. BBP and its metabolites can alter the cell cycle, affect the expression of key proteins, and disrupt the cytoskeleton structure of Sertoli cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Editorial Material
Hematology
Zuhre Kaya, Serap Kirkiz, Suzan Cinar, Ulker Kocak
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Engineering, Biomedical
Suleyman Serdar Alkanli, Fulya Dal Yontem, Merve Yasar, Celal Guven, M. Vezir Kahraman, Nilhan Kayaman Apohan, Zerrin Aktas, Mustafa Oral Oncul, Ayhan Unlu, Handan Akcakaya
Summary: Plastic antibodies can be used to neutralize biomacromolecules and have the potential for separation, purification, chemical sensor, catalysis, and drug production studies. These polymer nanoparticles have binding affinity and selectivity comparable to natural antibodies, reducing the cytotoxic effect of diphtheria toxin and inhibiting its damage on actin filaments, and can also be used for diagnostic purposes.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Polymer Science
Merve Yasar, Burcu Oktay, Fulya Dal Yontem, Ebru Haciosmanoglu Aldogan, Nilhan Kayaman Apohan
Summary: In this study, self-healing hydrogels were successfully prepared using a novel and simple technique with vanillin as a bio-based cross-linker. The hydrogel showed excellent self-healing ability under physiological conditions, and its cell viability was improved through collagen modification.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Genetics & Heredity
Asuman Gedikbasi, Guven Toksoy, Meryem Karaca, Cagri Gulec, Mehmet Cihan Balci, Dilek Gunes, Seda Gunes, Ayca Dilruba Aslanger, Gokcen Unverengil, Birsen Karaman, Seher Basaran, Mubeccel Demirkol, Gulden Fatma Gokcay, Zehra Oya Uyguner
Summary: In this study, bi-genomic DNA sequencing was performed to identify the genetic etiology in families with mitochondrial diseases. The results showed that 67% of the families were clarified by DNA sequencing, with 13% diagnosed through mtDNA sequencing and 54% through exome sequencing. The presence of weakness and muscle wasting highlighted the importance of considering limb-girdle muscular dystrophy as a differential diagnosis. Accurate diagnosis is crucial for genetic counseling and making appropriate treatment referrals.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Ozden Ozcan, Metin Yusuf Gelmez, Suzan Cinar, Gunnur Deniz, Melih Aktan
Summary: In this study, STAT3 and IL-10 levels were investigated in CLL patients. The results showed increased IL-10+CD19+, IL-10+ and STAT3+CD19+ in lymphocytes of patients compared to healthy subjects. The expression of IL-10 was found to be increased in CD19+ B cells of CLL patients, while the expression of STAT3 was lower in patients compared to healthy controls. These findings suggest that the levels of IL-10 and STAT3 expression in CLL B cells differ from normal B lymphocytes and may play a role in the biology of CLL.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2023)
Article
Medicine, General & Internal
Ayca Dilruba Aslanger, Cagri Gulec, Tugba Kalayci, Esma Sengenc, Sahin Avci, Umut Altunoglu, Volkan Karaman, Guven Toksoy, Meryem Karaca, Akin Iscan, Gulden Gokcay, Gozde Yesil, Oya Uyguner
Summary: We presented a case series of Tay-Sachs disease, described the clinical and molecular findings, and compared the genetic spectrum with previously reported mutations from Turkiye. The diagnosis was confirmed by determining the level of serum 0-hexosaminidase activity and the detection of a biallelic related variant upon Sanger sequencing of the HEXA gene. The clinical and molecular findings of nine cases were re-evaluated.
MEDICAL JOURNAL OF BAKIRKOY
(2023)
Article
Genetics & Heredity
Irem Kalay, Cagri Gulec, Mehmet Cihan Balci, Guven Toksoy, Gulden Gokcay, Seher Basaran, Mubeccel Demirkol, Zehra Oya Uyguner
Summary: This study identified 18 different sequence variants, including four novel variants, in 77 patients with classic galactosemia. The most common short-term finding was jaundice, while intellectual disability was one of the most common long-term complications. Patients with biallelic missense variants had a significantly higher prevalence of cataracts.
ANNALS OF HUMAN GENETICS
(2023)
Article
Endocrinology & Metabolism
Zehra Yavas Abali, Ezgi Gokpinar Ili, Firdevs Bas, Melis Ulak Ozkan, Cagri Gulec, Guven Toksoy, Ayse Pinar Ozturk, Esin Karakilic Ozturan, Ayca Aslanger, Mine Caliskan, Gozde Yesil, Sukran Poyrazoglu, Feyza Darendeliler, Zehra Oya Uyguner
Summary: This study evaluates the clinical and molecular characteristics of two patients with congenital hypopituitarism and neuropathy. The patients showed developmental delay, intellectual disability, and deficiencies in thyroid hormones, growth hormone, and prolactin. MRI revealed pituitary hypoplasia. A novel pathogenic variant in the RNPC3 gene was detected in both patients.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Hanife Yuksel Cakmak, Hasan Ege, Senanur Yilmaz, Gokhan Agturk, Fulya Dal Yontem, Gozde Enguven, Abdurrahman Sarmis, Zeren Cakmak, Oguzhan Gunduz, Zeynep Ruya Ege
Summary: The study investigated the wound healing and closure effect of Styrax liquidus (ST), extracted from Liquidambar orientalis Mill tree, loaded into 3D printed polylactic acid (PLA)/chitosan (CS) scaffolds. The morphological and chemical properties, as well as the mechanical and thermal properties of the ST loaded scaffolds, were analyzed. The antimicrobial activities of the scaffolds and their incubation media were tested on standard pathogenic bacteria. Cell viability and wound healing assays were conducted to evaluate the efficacy of the ST loaded scaffolds on human fibroblast cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Tugba Aydintug Gurbuz, Cagri Gulec, Fatih Toprak, Selin Toprak, Selcuk Sozer
Summary: This study investigates the effects of growth factors IGF-I and MGF on neural stem cells (NSCs) exposed to high glucose levels, and explores their potential applications in the treatment of diabetes patients. The findings demonstrate that administration of exogenous IGF-I and MGF can increase NSC proliferation and protect them from cell death. Furthermore, MGF exhibits greater neuroprotective effects compared to IGF-I.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Ayca Dilruba Aslanger, Tugba Kalayci, Esma Nur Konur, Cagri Gulec, Sahin Avci, Umut Altunoglu, Volkan Karaman, Guven Toksoy, Birsen Karaman, Seher Basaran, Zehra Uyguner, Gozde Yesil
Summary: This study compared the clinical and molecular findings of Roberts syndrome, emphasizing the possibility of making a definitive diagnosis through cytogenetic tests in the early intrauterine period. Pathogenic variants in the ESCO2 gene were identified in six cases, and it was discovered that the disease can occur in families without consanguinity.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ayse Pinar Ozturk, Ayca Aslanger, Esin Karakilic Ozturan, Esma Nur Konur, Cagri Gulec, Volkan Karaman, Melek Yildiz, Gozde Yesil, Guven Toksoy, Sukran Poyrazoglu, Firdevs Bas, Birsen Karaman, Zehra Oya Uyguner, Seher Basaran, Feyza Darendeliler
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Transplantation
Safak Mirioglu, Suzan Cinar, Omer Uludag, Erdem Gurel, Sibel Varelci, Yasemin Ozluk, Isin Kilicaslan, Yasemin Yalcinkaya, Halil Yazici, Ahmet Gul, Murat Inanc, Bahar Artim-Esen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Hematology
Metin Yusuf Gelmez, Fatma Betul Oktelik, Suzan Cinar, Murat Ozbalak, Ozden Ozluk, Melih Aktan, Gunnur Deniz
Summary: Chronic lymphocytic leukemia (CLL) patients have increased levels of T-FH and T-FC cells with higher expression of OX-40 and ICOS and lower expression of PD-L1. Compared to healthy individuals, CLL patients also have elevated expression of OX-40L, ICOS, and PD-L1 in B cells.
JOURNAL OF HEMATOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Cagri Gulec, Ayca Dilruba Aslanger, Volkan Karaman, Bernd Wollnik, Fatih Tepgec, Hulya Kayserili Karabey, Z. Oya Uyguner
Summary: This study investigated the GJB2 gene variants and their frequencies in NSHL patients in Turkey, finding 13 different variants in 35% of patients, with c.35delG being the most common. The results provide important information for genetic counseling of Turkish NSHL patients in the future.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2022)