Cutaneous pH landscape as a facilitator of melanoma initiation and progression

Melanoma tumors exhibit a variable but distinct metabolic signature

(2018) René G. Feichtinger et al.   EXPERIMENTAL DERMATOLOGY

Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks

(2018) Julien Massonneau et al.   FEBS Open Bio

Survival of patients with advanced metastatic melanoma: the impact of novel therapies–update 2017

(2017) Selma Ugurel et al.   EUROPEAN JOURNAL OF CANCER

NADPH Oxidase-1 Plays a Key Role in Keratinocyte Responses to UV Radiation and UVB-Induced Skin Carcinogenesis

(2017) Houssam Raad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

(2017) Elena Andreucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Checkpoint inhibitors in melanoma and early phase development in solid tumors: what’s the future?

(2017) Paolo A. Ascierto et al.   Journal of Translational Medicine

Current status and future direction in the management of malignant melanoma

(2017) Patrick Gladfelter et al.   MELANOMA RESEARCH

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

NRAS-mutant melanoma: current challenges and future prospect

(2017) Eva Muñoz-Couselo et al.   OncoTargets and Therapy

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

(2017) Petko Fiziev et al.   Cell Reports

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

(2017) Yvonne Vercoulen et al.   eLife

Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas

(2017) Katanya C. Alaga et al.   Journal of Cancer

Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells

(2017) Verena Hofschröer et al.   Scientific Reports

New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations

(2016) Anna Ferretta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Subcellular ROS imaging methods: Relevance for the study of calcium signaling

(2016) David M. Booth et al.   CELL CALCIUM

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4

(2016) Céline Pinheiro et al.   CELL CYCLE

Increase inNRASmutant allele percentage during metastatic melanoma progression

(2016) Elisa Funck-Brentano et al.   EXPERIMENTAL DERMATOLOGY

BRAF and epithelial-mesenchymal transition in primary cutaneous melanoma: a role for Snail and E-cadherin?

(2016) Brendon Mitchell et al.   HUMAN PATHOLOGY

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

(2016) Cristina Federici et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031

(2016) David C. Whiteman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melanoma progression

(2016) David E. Elder   PATHOLOGY

Acidic tumor microenvironment in human melanoma

(2016) Ines Böhme et al.   Pigment Cell & Melanoma Research

TPC2 controls pigmentation by regulating melanosome pH and size

(2016) Andrea L. Ambrosio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

(2016) Alzbeta Hulikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

(2016) Scott K. Parks et al.   Oncotarget

Proton channels and exchangers in cancer

(2015) Enrico Pierluigi Spugnini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ion channels and transporters in metastasis

(2015) Christian Stock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity

(2015) A Tittarelli et al.   BRITISH JOURNAL OF CANCER

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Stratum corneum acidification: how and why?

(2015) Peter M. Elias   EXPERIMENTAL DERMATOLOGY

Dissecting the formation, structure and barrier function of the stratum corneum

(2015) Takeshi Matsui et al.   INTERNATIONAL IMMUNOLOGY

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosomes released by keratinocytes modulate melanocyte pigmentation

(2015) Alessandra Lo Cicero et al.   Nature Communications

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo

(2015) Orsolya Kiraly et al.   PLoS Genetics

Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

(2015) Bree K Grillo-Hill et al.   eLife

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

(2015) Schammim Ray Amith et al.   Oncotarget

Expression of cancer-related carbonic anhydrases IX and XII in normal skin and skin neoplasms

(2014) Leo Syrjänen et al.   APMIS

Updates of reactive oxygen species in melanoma etiology and progression

(2014) Feng Liu-Smith et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metalloproteinases in melanoma

(2014) Nives Moro et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Melanocytes as Instigators and Victims of Oxidative Stress

(2014) Laurence Denat et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Acidic priming enhances metastatic potential of cancer cells

(2014) Anne Riemann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion channels and transporters in tumour cell migration and invasion

(2014) A. Schwab et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

UV Signature Mutations

(2014) Douglas E. Brash   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Skin as a living coloring book: how epithelial cells create patterns of pigmentation

(2014) Lorin Weiner et al.   Pigment Cell & Melanoma Research

Role of lipids in the formation and maintenance of the cutaneous permeability barrier

(2013) Kenneth R. Feingold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

sPLA2 and the epidermal barrier

(2013) Dusko Ilic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Na+/H+exchanger 1 (NHE1) function is necessary for maintaining mammary tissue architecture

(2013) Edmund C. Jenkins et al.   DEVELOPMENTAL DYNAMICS

Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility

(2013) ANNE-KRISTIN VAHLE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Connexin43 Reduces Melanoma Growth within a Keratinocyte Microenvironment and during Tumorigenesisin Vivo

(2013) Mark J. Ableser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

(2013) MARIA RAFFAELLA GRECO et al.   ONCOLOGY REPORTS

Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation

(2013) Fernanda Molognoni et al.   PLoS One

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

Surgery for Distant Melanoma Metastasis

(2012) Anna M. Leung et al.   CANCER JOURNAL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression

(2012) Joseph J. Provost et al.   Chemical Biology & Drug Design

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions

(2012) Florian Timo Ludwig et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BRAF/NRASMutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

(2012) Maria Colombino et al.   JOURNAL OF CLINICAL ONCOLOGY

Irradiation of Skin with Visible Light Induces Reactive Oxygen Species and Matrix-Degrading Enzymes

(2012) Frank Liebel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NADPH Oxidase 1 Overexpression Enhances Invasion via Matrix Metalloproteinase-2 and Epithelial–Mesenchymal Transition in Melanoma Cells

(2012) Feng Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

Histone Acetylation Regulates Intracellular pH

(2012) Matthew A. McBrian et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasome Activation of IL-1 Family Mediators in Response to Cutaneous Photodamage†

(2012) Tahseen H. Nasti et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease

(2012) Christopher M. Dooley et al.   Pigment Cell & Melanoma Research

Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids

(2012) Cyrill Géraud et al.   PLoS One

Understanding the Melanocyte Distribution in Human Epidermis: An Agent-Based Computational Model Approach

(2012) Josef Thingnes et al.   PLoS One

NRAS mutation status is an independent prognostic factor in metastatic melanoma

(2011) John A. Jakob et al.   CANCER

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP

(2011) Yani Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP

(2011) Yani Lin et al.   EXPERIMENTAL CELL RESEARCH

B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+Exchanger

(2011) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanosomes Are Transferred from Melanocytes to Keratinocytes through the Processes of Packaging, Release, Uptake, and Dispersion

(2011) Hideya Ando et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

How are proliferation and differentiation of melanocytes regulated?

(2011) Tomohisa Hirobe   Pigment Cell & Melanoma Research

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

(2011) Ranjani K. Paradise et al.   PLoS One

Transmigration of Melanoma Cells through the Blood-Brain Barrier: Role of Endothelial Tight Junctions and Melanoma-Released Serine Proteases

(2011) Csilla Fazakas et al.   PLoS One

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

(2011) Anne Riemann et al.   PLoS One

2D luminescence imaging of pH in vivo

(2011) S. Schreml et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular pH gradients in migrating cells

(2010) Christine Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

(2010) J.-H. Lee et al.   BRITISH JOURNAL OF DERMATOLOGY

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032

(2010) Jill C Rubinstein et al.   Journal of Translational Medicine

Chronic inflammation and mutagenesis

(2010) Lynnette R. Ferguson   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

(2010) P Swietach et al.   ONCOGENE

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

(2009) David B. Seligson et al.   AMERICAN JOURNAL OF PATHOLOGY

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function

(2009) Roshan Gunathilake et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Protons make tumor cells move like clockwork

(2009) Christian Stock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study

(2008) Robert M. Mentzer et al.   ANNALS OF THORACIC SURGERY

Lamellar Bodies of Human Epidermis

(2008) Anne-Aurélie Raymond et al.   MOLECULAR & CELLULAR PROTEOMICS

The reactive oxygen-driven tumor: relevance to melanoma

(2008) Levi Fried et al.   Pigment Cell & Melanoma Research