Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue

(2018) Ahmed Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of CB 2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease

(2017) Jiang Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

(2017) Anne-Claire Dupont et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats

(2017) Geraldine Pottier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Radioligands for positron emission tomography imaging of cannabinoid type 2 receptor

(2017) Francesco Spinelli et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

(2017) Teruyo Hosoya et al.   Journal of Neuroinflammation

From Structure–Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging

(2017) Fabien Caillé et al.   MOLECULAR PHARMACEUTICS

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [ 11 C]RS-016 targeting CB2 in atherosclerosis

(2017) Romana Meletta et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of Highly Affine and Selective Fluorinated Cannabinoid Type 2 Receptor Ligands

(2017) Rareş-Petru Moldovan et al.   ACS Medicinal Chemistry Letters

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer’s Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine

(2016) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

(2016) Rareş-Petru Moldovan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

(2016) Roger Slavik et al.   JOURNAL OF NEUROCHEMISTRY

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus

(2016) A. Vanessa Stempel et al.   NEURON

Stimulation of brain glucose uptake by cannabinoid CB 2 receptors and its therapeutic potential in Alzheimer's disease

(2016) Attila Köfalvi et al.   NEUROPHARMACOLOGY

Pharmacological benefits of selective modulation of cannabinoid receptor type 2 (CB2) in experimental Alzheimer's disease

(2016) Shalini Jayant et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke

(2016) Isabel Bravo-Ferrer et al.   STROKE

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

(2016) Ahmed Haider et al.   Frontiers in Neuroscience

Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

(2016) Muneer Ahamed et al.   Frontiers in Neuroscience

Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions

(2015) James Varley et al.   Alzheimers & Dementia

Design, synthesis and preliminary evaluation of 18F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor

(2015) Giuseppe Saccomanni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

(2015) Roger Slavik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands

(2015) Simone Bertini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

(2015) Sari Yrjölä et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cannabinoids in Experimental Stroke: A Systematic Review and Meta-Analysis

(2015) Timothy J England et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor

(2015) Roger Slavik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimized Quantification of Translocator Protein Radioligand 18F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers

(2015) S. Lavisse et al.   JOURNAL OF NUCLEAR MEDICINE

A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice

(2015) Richard D. Ronca et al.   LIFE SCIENCES

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Endocannabinoid signalling and the deteriorating brain

(2015) Vincenzo Di Marzo et al.   NATURE REVIEWS NEUROSCIENCE

Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model

(2015) Anne-Caroline Schmöle et al.   NEUROBIOLOGY OF AGING

Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus

(2015) Y. Li et al.   NEUROSCIENCE

The choreography of neuroinflammation in Huntington's disease

(2015) Andrea Crotti et al.   TRENDS IN IMMUNOLOGY

Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation

(2015) Alena V. Savonenko et al.   PLoS One

Time-Dependent Protection of CB2 Receptor Agonist in Stroke

(2015) Seong-Jin Yu et al.   PLoS One

Development and Evaluation of Novel PET Tracers for Imaging Cannabinoid Receptor Type 2 in Brain

(2014) Roger Slavik et al.   CHIMIA

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Cannabinoid CB2receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

(2014) Hai-Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human side of microglia

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Radiolabeling andin vitro/in vivoevaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor

(2013) Linjing Mu et al.   JOURNAL OF NEUROCHEMISTRY

Radiation Dose of the P-Glycoprotein Tracer 11C-Laniquidar

(2013) A. Postnov et al.   JOURNAL OF NUCLEAR MEDICINE

Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial

(2013) John Zajicek et al.   LANCET NEUROLOGY

Whole-Body Biodistribution and Radiation Dosimetry of the Cannabinoid Type 2 Receptor Ligand [11C]-NE40 in Healthy Subjects

(2013) Rawaha Ahmad et al.   MOLECULAR IMAGING AND BIOLOGY

Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model

(2012) Caroline Vandeputte et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

(2012) Maite Solas et al.   NEUROBIOLOGY OF AGING

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging

(2011) Nele Evens et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Brain cannabinoid CB2 receptors modulate cocaine's actions in mice

(2011) Zheng-Xiong Xi et al.   NATURE NEUROSCIENCE

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

(2011) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage/Microglial Activation Concomitant to Neuroprotection

(2011) Juan G. Zarruk et al.   STROKE

Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging

(2010) Mingzhang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

(2010) Andrew G. Horti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

The CB2Cannabinoid Receptor Controls Myeloid Progenitor Trafficking

(2008) Javier Palazuelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Labelling and biological evaluation of [11C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor

(2008) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Cannabinoid CB2receptors in human brain inflammation

(2007) C Benito et al.   BRITISH JOURNAL OF PHARMACOLOGY