Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice

Transcriptome inference and systems approaches to polypharmacology and drug discovery in herbal medicine

(2017) Peng Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains

(2017) Li Chen et al.   NEUROLOGICAL RESEARCH

Tyrosine-mutated AAV2-mediated shRNA silencing of PTEN promotes axon regeneration of adult optic nerve

(2017) ZhengRu Huang et al.   PLoS One

Knockdown of FSTL1 inhibits oxLDL-induced inflammation responses through the TLR4/MyD88/NF-κB and MAPK pathway

(2016) Junxia Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus

(2016) Peng Wang et al.   BRAIN RESEARCH

Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia

(2016) Bing Li et al.   CNS & Neurological Disorders-Drug Targets

Toll-like receptors and interferon associated immune factors responses to spring viraemia of carp virus infection in common carp (Cyprinus carpio)

(2016) Xinxian Wei et al.   FISH & SHELLFISH IMMUNOLOGY

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

(2016) Liyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation

(2016) Xin Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2016) Valery L Feigin et al.   LANCET NEUROLOGY

Antigen Presentation After Stroke

(2016) Francesc Miró-Mur et al.   Neurotherapeutics

Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway

(2016) Chunhui Zhao et al.   PLoS One

Phenotype-dependent alteration of pathways and networks reveals a pure synergistic mechanism for compounds treating mouse cerebral ischemia

(2015) Peng-qian Wang et al.   ACTA PHARMACOLOGICA SINICA

Diverse array-designed modes of combination therapies in Fangjiomics

(2015) Jun Liu et al.   ACTA PHARMACOLOGICA SINICA

Fangjiomics: revealing adaptive omics pharmacological mechanisms of the myriad combination therapies to achieve personalized medicine

(2015) Dayue Darrel Duan et al.   ACTA PHARMACOLOGICA SINICA

Pancreatic Changes in Nerve Growth Factor/TrkA Associated with Insulin Secretion in Cerebral Ischemia

(2015) Kei Miyagi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The mechanism and function of mitogen-activated protein kinase activation by ARF1

(2015) Fuguo Zhou et al.   CELLULAR SIGNALLING

Editorial (Thematic Issue): Combination Therapy of Vascular Diseases and Fangjiomics: When West Meets East in the Era of Phenomics

(2015) Zhong Wang et al.   Current Vascular Pharmacology

GRIN1mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders

(2015) Chihiro Ohba et al.   EPILEPSIA

Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

(2015) YiMei Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

(2015) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Deficiency of the B Cell-Activating Factor Receptor Results in Limited CD169+Macrophage Function during Viral Infection

(2015) Haifeng C. Xu et al.   JOURNAL OF VIROLOGY

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

(2015) Rita V. Krishnamurthi et al.   NEUROEPIDEMIOLOGY

Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

(2015) Cui Lv et al.   NEUROPHARMACOLOGY

An Analysis of Chemical Ingredients Network of Chinese Herbal Formulae for the Treatment of Coronary Heart Disease

(2015) Fan Ding et al.   PLoS One

PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology

(2014) Tsz Hang Wong et al.   BRAIN

Scutellaria baicalensis in stroke management: Nature’s blessing in traditional Eastern medicine

(2014) Bhakta Prasad Gaire et al.   Chinese Journal of Integrative Medicine

Androgens and stroke: Good, bad or indifferent?

(2014) Nidia Quillinan et al.   EXPERIMENTAL NEUROLOGY

Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2′-5′ oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection

(2014) Mizuho Tsutsui-Takeuchi et al.   IMMUNOLOGIC RESEARCH

Curcumin Inhibits TLR2/4-NF-κB Signaling Pathway and Attenuates Brain Damage in Permanent Focal Cerebral Ischemia in Rats

(2014) Xian-kun Tu et al.   INFLAMMATION

Grin1 Receptor Deletion within CRF Neurons Enhances Fear Memory

(2014) Georgette Gafford et al.   PLoS One

Immunological consequences of ischemic stroke

(2013) A. Vogelgesang et al.   ACTA NEUROLOGICA SCANDINAVICA

Systems pharmacology in drug discovery and therapeutic insight for herbal medicines

(2013) Chao Huang et al.   BRIEFINGS IN BIOINFORMATICS

Modern bioinformatics meets traditional Chinese medicine

(2013) P. Gu et al.   BRIEFINGS IN BIOINFORMATICS

Hierarchical Profiles of Signaling Pathways and Networks Reveal Two Complementary Pharmacological Mechanisms

(2013) Yinying Chen et al.   CNS & Neurological Disorders-Drug Targets

Outcome-Dependent Global Similarity Analysis of Imbalanced Core Signaling Pathways in Ischemic Mouse Hippocampus

(2013) Jun Liu et al.   CNS & Neurological Disorders-Drug Targets

Convergent and Divergent Pathways Decoding Hierarchical Additive Mechanisms in Treating Cerebral Ischemia-Reperfusion Injury

(2013) Ying-Ying Zhang et al.   CNS Neuroscience & Therapeutics

Up-regulation of the canonical Wnt-3A and Sonic hedgehog signaling underlies melanocortin-induced neurogenesis after cerebral ischemia

(2013) Luca Spaccapelo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury

(2013) Mingjing Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia–reperfusion injury

(2013) Yinying Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats

(2013) Junying Zhang et al.   PLoS One

Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology

(2013) Jiangyong Gu et al.   PLoS One

Synergistic Mechanism of Gene Expression and Pathways between Jasminoidin and Ursodeoxycholic Acid in Treating Focal Cerebral Ischemia-Reperfusion Injury

(2012) Jun Liu et al.   CNS Neuroscience & Therapeutics

Post-Stroke Immunodeficiency: Effects of Sensitization and Tolerization to Brain Antigens

(2012) Arash Esmaeili et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia

(2012) Famakin Bolanle et al.   Journal of Neuroinflammation

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

(2012) Matthew Traylor et al.   LANCET NEUROLOGY

EGCG Ameliorates the Suppression of Long-Term Potentiation Induced by Ischemia at the Schaffer Collateral-CA1 Synapse in the Rat

(2011) Jie Ding et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy

(2011) Zhong Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fangjiomics: In Search of Effective and Safe Combination Therapies

(2011) Zhong Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection

(2011) V. Vezys et al.   JOURNAL OF IMMUNOLOGY

Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats

(2011) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation

(2010) Xia Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

(2009) Martijn A. Nolte et al.   IMMUNOLOGICAL REVIEWS

Dose-Dependent Effects of Androgens on Outcome after Focal Cerebral Ischemia in Adult Male Mice

(2009) Masayoshi Uchida et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Predicting promiscuity

(2009) Andrew L. Hopkins   NATURE

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotective Effect of Baicalin in a Rat Model of Permanent Focal Cerebral Ischemia

(2009) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study

(2009) Zhanjun Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Exaggeration of Focal Cerebral Ischemia in Transgenic Mice Carrying Human Renin and Human Angiotensinogen Genes

(2008) Shinji Inaba et al.   STROKE