Article
Biochemistry & Molecular Biology
Lidan Wu, Na Zhao, Wenjie Jiang, Fengshan Wang
Summary: This study investigated the effects of porcine mucosa-derived heparan sulfate (PMHS) on A beta-induced neurotoxicity in vitro and in vivo. The results showed that PMHS could ameliorate inflammation and apoptosis response in vitro, and improve cognitive impairment and inhibit neuroinflammation and apoptosis in the brain in vivo. Furthermore, PMHS lowered A beta levels by improving the phagocytosis function of neutrophils. This study suggests that PMHS could be developed as a neuroprotective drug for Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Cristina Benatti, Nicolo Musso, Claudia G. Fresta, Annamaria Fidilio, Giorgia Spampinato, Nicoletta Brunello, Claudio Bucolo, Filippo Drago, Susan M. Lunte, Blake R. Peterson, Fabio Tascedda, Filippo Caraci
Summary: The study showed that carnosine can protect macrophages from cell death and apoptosis induced by Aβ 1-42 oligomers, decrease oxidative stress, enhance macrophage phagocytic activity, and rescue fractalkine receptor CX3CR1. These new findings support the therapeutic potential of carnosine in the context of AD pathology, highlighting its multimodal mechanism of action.
Article
Cell Biology
Savannah A. Lynn, David A. Johnston, Jenny A. Scott, Rosie Munday, Roshni S. Desai, Eloise Keeling, Ruaridh Weaterton, Alexander Simpson, Dillon Davis, Thomas Freeman, David S. Chatelet, Anton Page, Angela J. Cree, Helena Lee, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Summary: The accumulation of A beta in the retina causes AMD-like pathology and damages endothelial and RPE cells, impairing RPE function. Unlike internalized POS, the accumulation of A beta in lysosomes and lysosomal deficiency elicit a different response in retinal degeneration.
Article
Chemistry, Inorganic & Nuclear
Qianqian Zhang, Yiqing Liu, Jinming Wu, Lizhen Zeng, Jingjing Wei, Shitao Fu, Huixian Ye, Hailing Li, Zhonghong Gao
Summary: Although the exact molecular mechanism of Alzheimer's disease (AD) is still unclear, compounds that can inhibit the aggregation of amyloid-beta peptide or scavenge the highly toxic peroxynitrite free radical have been confirmed to delay or alleviate AD. This study aimed to investigate the inhibitory effects of metalloporphyrins on the aggregation of amyloid-beta peptide and explore their structure-activity relationship.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Cell Biology
Xinpei Zhou, Ximin Tang, Tao Li, Dandan Li, Zhiting Gong, Xiujun Zhang, Yanjiao Li, Jianhua Zhu, Yong Wang, Bensi Zhang
Summary: This study aimed to investigate the mechanism of action of VDAC1 in mitochondrial dysfunction and ferroptosis in AD neurons. The results showed that inhibition of VDAC1 alleviated mitochondrial dysfunction and ferroptosis in AD neurons by activating the AMPK/mTOR and Wnt/beta-catenin pathways, making it a potential target for AD treatment.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Michael Kimura, Mayumi Tsuji, Taro Yasumoto, Yukiko Mori, Tatsunori Oguchi, Yuya Tsuji, Masakazu Umino, Asami Umino, Toru Nishikawa, Shiro Nakamura, Tomio Inoue, Yuji Kiuchi, Masahito Yamada, David B. Teplow, Kenjiro Ono
Summary: Accumulation of amyloid beta-protein is a primary mechanism leading to neuronal death in Alzheimer's disease, with protofibrils being a key target for disease-modifying therapy. Previous studies have shown that phenolic compounds like myricetin can inhibit aggregations of beta-amyloid and alpha-synuclein, providing protective effects against AD and Parkinson's disease. This study demonstrates that myricetin can protect against HMW-A beta o-induced neurotoxicity through multiple antioxidant functions, suggesting its potential as a disease-modifying agent for AD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Hongmei Ning, Chong Li, Zhihong Yin, Dongfang Hu, Yaming Ge, Lingli Chen
Summary: The study revealed that high concentrations of fluoride (1.5, 2, and 2.5 mM) exerted significant toxic effects on the cellular morphologies and neural formation of primary cultured cortical neurons.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li
Summary: The study showed that geniposide can protect against A beta(1-42)-induced toxicity by inhibiting phosphorylation of the Akt/mTOR signaling pathway and enhancing autophagy. These findings suggest that geniposide may have potential therapeutic implications for Alzheimer's disease by targeting these molecular mechanisms.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Oncology
Dan Xu, Ping Yang, Zhang-Jian Yang, Qiu-Gen Li, Ye-Tong Ouyang, Ting Yu, Jian-Hui Shangguan, Yu-Ying Wan, Li-Ping Jiang, Xin-Hui Qu, Xiao-Jian Han
Summary: The study demonstrated that blocking Drp1 phosphorylation at Ser579 can effectively protect neurons against A beta(1-42)-induced degeneration and apoptosis, highlighting the therapeutic potential of targeting Drp1 in the treatment of Alzheimer's disease.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Neurosciences
Menglin Zheng, Ke Li, Tong Chen, Shengnan Liu, Ling He
Summary: The study revealed that GEN exerts a beneficial effect on LPS-induced depression in mice by modulating the BTK/JAK2/STAT1 signaling pathway, improving anxiety- and depression-like behaviors, regulating microglial polarization, and inhibiting pro-inflammatory cytokine production.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Kai-Ji He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu
Summary: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons and the accumulation of alpha-synuclein. This study reveals the interaction between oligomeric alpha-synuclein (O-alpha S) and Leucine-Rich Repeat Kinase 2 (LRRK2) in glial cells, and suggests that inhibiting LRRK2 kinase activity could suppress neuroinflammation in PD through the NF-kappa B pathway.
Article
Plant Sciences
Fatima Javed Mirza, Sanila Amber, Sumera, Deeba Hassan, Touqeer Ahmed, Saadia Zahid
Summary: The study demonstrated the proneurogenic effects of rosmarinic acid and ursolic acid in an A beta(1-42)-induced AD mouse model, showing protection against deficits in spatial and recognition memory and changes in anxiety. Treatment with these compounds normalized neuronal density and levels of neurogenic and synaptic markers.
Article
Food Science & Technology
Jikai Xu, Jingyu Liu, Qing Li, Yan Mi, Di Zhou, Qingqi Meng, Gang Chen, Ning Li, Yue Hou
Summary: Pterostilbene alleviates Aβ(1-42)-induced cognitive dysfunction in mice possibly by inhibiting oxidative stress through the Nrf2 signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Jing Wang, Yan Ding, Linwu Zhuang, Zhenzhong Wang, Wei Xiao, Jingbo Zhu
Summary: The study found that Ginkgolide B (GB) can alleviate Aβ(1-42)-induced astrocyte apoptosis, inhibit endoplasmic reticulum stress, oxidative stress, energy metabolism disorders, and Aβ(1-42) production by activating the AMPK signaling pathway. This provides a basis for the innovative use of GB as a therapeutic agent for Aβ(1-42)-related Alzheimer's disease.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Zhihui Yin, Xinyue Geng, Zhengyi Zhang, Ying Wang, Xiaoyan Gao
Summary: The study investigated the antioxidant activity of rhein against Aβ (1-42) oligomer-induced mitochondrial oxidative stress and found that rhein reduced ROS levels, protected mitochondrial function, and prevented oxidative stress-related apoptosis in neurons. Rhein also activated mitochondrial biogenesis through the SIRT1/PGC-1 α pathway, acting as an antioxidant defense system against Aβ-induced oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)