Systems pharmacology in drug discovery and therapeutic insight for herbal medicines

Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice

(2013) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

A systematic identification of multiple toxin–target interactions based on chemical, genomic and toxicological data

(2013) Wei Zhou et al.   TOXICOLOGY

Towards a bioinformatics analysis of anti-Alzheimer's herbal medicines from a target network perspective

(2012) Y. Sun et al.   BRIEFINGS IN BIOINFORMATICS

Pharmacogenomics Knowledge for Personalized Medicine

(2012) M Whirl-Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

(2012) Xia Wang et al.   Evidence-based Complementary and Alternative Medicine

Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication

(2012) Xia Wang et al.   Integrative Biology

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease

(2012) Bohui Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

(2012) Xue Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Comparative Toxicogenomics Database: update 2013

(2012) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

A Systematic Prediction of Multiple Drug-Target Interactions from Chemical, Genomic, and Pharmacological Data

(2012) Hua Yu et al.   PLoS One

A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment

(2012) Xiuxiu Li et al.   PLoS One

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

(2011) John A. Allen et al.   Annual Review of Pharmacology and Toxicology

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

MiR-206-mediated dynamic mechanism of the mammalian circadian clock

(2011) Wei Zhou et al.   BMC Systems Biology

The Roles of Neurotrophic Factor and Wnt Signaling in Depression

(2011) B Voleti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ADME Properties of Herbal Medicines in Humans: Evidence, Challenges and Strategies

(2011) Shu-Ming He et al.   CURRENT PHARMACEUTICAL DESIGN

P-glycoprotein Substrate Models Using Support Vector Machines Based on a Comprehensive Data set

(2011) Zhi Wang et al.   Journal of Chemical Information and Modeling

A classification study of human β 3-adrenergic receptor agonists using BCUT descriptors

(2011) Ming Hao et al.   MOLECULAR DIVERSITY

Convergence: Where West meets East

(2011) Peng Tian   NATURE

TCM: Made in China

(2011) Felix Cheung   NATURE

Perspective: All systems go

(2011) Jan van der Greef   NATURE

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Computational Prediction of Heme-Binding Residues by Exploiting Residue Interaction Network

(2011) Rong Liu et al.   PLoS One

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Network Systems Biology for Drug Discovery

(2010) D K Arrell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Systems Biology: An Approach

(2010) P Kohl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes

(2010) Juho Hokkanen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Second-tier natural antidepressants: Review and critique

(2010) Nadia Iovieno et al.   JOURNAL OF AFFECTIVE DISORDERS

HIT: linking herbal active ingredients to targets

(2010) H. Ye et al.   NUCLEIC ACIDS RESEARCH

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Pharmacogenomics and bioinformatics: PharmGKB

(2010) Caroline F Thorn et al.   PHARMACOGENOMICS

No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression

(2010) Alessandro Serretti et al.   PSYCHIATRY RESEARCH

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

A prediction model for blood–brain barrier permeation and analysis on its parameter biologically

(2009) Yan Chen et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Brain drug targeting: a computational approach for overcoming blood–brain barrier

(2009) Ahmad Reza Mehdipour et al.   DRUG DISCOVERY TODAY

Computational approaches to predict drug metabolism

(2009) Paul Czodrowski et al.   Expert Opinion on Drug Metabolism & Toxicology

Multivariate global sensitivity analysis for dynamic crop models

(2009) Matieyendou Lamboni et al.   FIELD CROPS RESEARCH

Monoamine oxidase inhibition by Rhodiola rosea L. roots

(2009) Daphne van Diermen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

The IntAct molecular interaction database in 2010

(2009) B. Aranda et al.   NUCLEIC ACIDS RESEARCH

Selective serotonin reuptake inhibitors pathway

(2009) Katrin Sangkuhl et al.   Pharmacogenetics and Genomics

“Killing the Blues”: A role for cellular suicide (apoptosis) in depression and the antidepressant response?

(2009) Declan P. McKernan et al.   PROGRESS IN NEUROBIOLOGY

A Dynamic Network Approach for the Study of Human Phenotypes

(2009) César A. Hidalgo et al.   PLoS Computational Biology

Identifying gene-disease associations using centrality on a literature mined gene-interaction network

(2008) A. Ozgur et al.   BIOINFORMATICS

COX-2 Inhibition in Schizophrenia and Major Depression

(2008) Norbert Muller et al.   CURRENT PHARMACEUTICAL DESIGN

Data completeness—the Achilles heel of drug-target networks

(2008) Jordi Mestres et al.   NATURE BIOTECHNOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

QSAR Modeling of the Blood–Brain Barrier Permeability for Diverse Organic Compounds

(2008) Liying Zhang et al.   PHARMACEUTICAL RESEARCH

Pharmacologicalin vivotest to evaluate the bioavailability of some St John's Wort innovative oral preparations

(2008) B. Isacchi et al.   PHYTOTHERAPY RESEARCH

Role of the brain-derived neurotrophic factor at glutamatergic synapses

(2007) A L Carvalho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Estimation of ADME Properties in Drug Discovery: Predicting Caco-2 Cell Permeability Using Atom-Based Stochastic and Non-stochastic Linear Indices

(2007) Juan A. Castillo-Garit et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparative study of Rhodiola preparations on behavioral despair of rats

(2007) A. Panossian et al.   PHYTOMEDICINE