Towards human exploration of space: the THESEUS review series on muscle and bone research priorities

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

(2016) Marlou L. Dirks et al.   DIABETES

WISE 2005: Aerobic and resistive countermeasures prevent paraspinal muscle deconditioning during 60-day bed rest in women

(2016) Jacquelyn A. Holt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Long-duration bed rest as an analog to microgravity

(2016) Alan R. Hargens et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of hindlimb unloading and ionizing radiation on skeletal muscle resistance artery vasodilation and its relation to cancellous bone in mice

(2016) Rhonda D. Prisby et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases

(2016) Nada Sallam et al.   Oxidative Medicine and Cellular Longevity

Effects of High-LET Radiation Exposure and Hindlimb Unloading on Skeletal Muscle Resistance Artery Vasomotor Properties and Cancellous Bone Microarchitecture in Mice

(2016) Payal Ghosh et al.   RADIATION RESEARCH

Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse

(2016) Elfego Galvan et al.   Nutrients

Leucine partially protects muscle mass and function during bed rest in middle-aged adults1,2

(2015) Kirk L English et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mechanical loading causes site-specific anabolic effects on bone following exposure to ionizing radiation

(2015) Yasaman Shirazi-Fard et al.   BONE

Bone metabolism and renal stone risk during International Space Station missions

(2015) Scott M. Smith et al.   BONE

Physical exercise, neuroplasticity, spatial learning and memory

(2015) Ricardo C. Cassilhas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?

(2015) Daniel L. Belavy et al.   EUROPEAN SPINE JOURNAL

Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest

(2015) Daniel L. Belavý et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation

(2015) Ruth E. Tanner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microgravity promotes osteoclast activity in medaka fish reared at the international space station

(2015) Masahiro Chatani et al.   Scientific Reports

Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest

(2015) Michele Salanova et al.   Scientific Reports

Isokinetic Strength Changes Following Long-Duration Spaceflight on the ISS

(2015) Kirk L. English et al.   Aerospace Medicine and Human Performance

Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity

(2015) Jessica Aceto et al.   PLoS One

Consequences of irradiation on bone and marrow phenotypes, and its relation to disruption of hematopoietic precursors

(2014) Danielle E. Green et al.   BONE

Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters

(2014) Paula Hoff et al.   Cellular & Molecular Immunology

Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis

(2014) Michele Salanova et al.   FASEB JOURNAL

WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women

(2014) Stuart M. C. Lee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Partial gravity unloading inhibits bone healing responses in a large animal model

(2014) Benjamin C. Gadomski et al.   JOURNAL OF BIOMECHANICS

Men and Women in Space: Bone Loss and Kidney Stone Risk After Long-Duration Spaceflight

(2014) Scott M Smith et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Limited Clinical Utility of a Genetic Risk Score for the Prediction of Fracture Risk in Elderly Subjects

(2014) Joel Eriksson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of Sex and Gender on Adaptation to Space: Musculoskeletal Health

(2014) Lori Ploutz-Snyder et al.   JOURNAL OF WOMENS HEALTH

Muscle Atrophy, Pain, and Damage in Bed Rest Reduced by Resistive (Vibration) Exercise

(2014) TANJA MIOKOVIC et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Calcium kinetics during bed rest with artificial gravity and exercise countermeasures

(2014) S. M. Smith et al.   OSTEOPOROSIS INTERNATIONAL

Mice in Bion-M 1 Space Mission: Training and Selection

(2014) Alexander Andreev-Andrievskiy et al.   PLoS One

Stem Cell Health and Tissue Regeneration in Microgravity

(2014) Elizabeth Blaber et al.   STEM CELLS AND DEVELOPMENT

Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures

(2013) Laurence Stevens et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Novel Lunar Bed Rest Analogue

(2013) Peter R. Cavanagh et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Acute exposure to high dose γ-radiation results in transient activation of bone lining cells

(2013) Russell T. Turner et al.   BONE

Optimising muscle parameters in musculoskeletal models using Monte Carlo simulation

(2013) Erik B. Reed et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrated Resistance and Aerobic Exercise Protects Fitness during Bed Rest

(2013) LORI L. PLOUTZ-SNYDER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight

(2013) A. LeBlanc et al.   OSTEOPOROSIS INTERNATIONAL

Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure

(2013) Lavinia Paternoster et al.   PLoS Genetics

Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men

(2012) Guy Trudel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Bone metabolism and nutritional status during 30-day head-down-tilt bed rest

(2012) Jennifer L. L. Morgan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry

(2012) Scott M Smith et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Sclerostin Increases in Healthy Adult Men during Bed Rest

(2012) J. M. Spatz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Mice Drawer System (MDS) Experiment and the Space Endurance Record-Breaking Mice

(2012) Ranieri Cancedda et al.   PLoS One

Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle

(2011) Stine Ringholm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Miniaturized Sensors to Monitor Simulated Lunar Locomotion

(2011) Andrea M. Hanson et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Male–female differences in the association between incident hip fracture and proximal femoral strength: A finite element analysis study

(2011) J.H. Keyak et al.   BONE

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise

(2011) Michele Salanova et al.   FASEB JOURNAL

Long-Duration Space Flight and Bed Rest Effects on Testosterone and Other Steroids

(2011) Scott M. Smith et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight

(2010) R. Dana Carpenter et al.   ACTA ASTRONAUTICA

Risk of Herniated Nucleus Pulposus Among U.S. Astronauts

(2010) Smith L. Johnston et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses

(2010) J.S. Alwood et al.   BONE

Countermeasures against lumbar spine deconditioning in prolonged bed rest: resistive exercise with and without whole body vibration

(2010) Daniel L. Belavý et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mechanisms regulating muscle mass during disuse atrophy and rehabilitation in humans

(2010) Kanagaraj Marimuthu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Foot forces during exercise on the International Space Station

(2010) K.O. Genc et al.   JOURNAL OF BIOMECHANICS

Response to questions regarding conclusions reached in “Age dependence of femoral strength in white women and men”

(2010) Tony M Keaveny   JOURNAL OF BONE AND MINERAL RESEARCH

Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres

(2010) R. H. Fitts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Shoulder Injuries Attributed to Resistance Training: A Brief Review

(2010) Morey J Kolber et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Musculoskeletal Adaptations to Training with the Advanced Resistive Exercise Device

(2010) JAMES A. LOEHR et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest

(2010) D. L. Belavý et al.   OSTEOPOROSIS INTERNATIONAL

Short-Term Effects of Whole-Body Exposure to56Fe Ions in Combination with Musculoskeletal Disuse on Bone Cells

(2010) Kenji Yumoto et al.   RADIATION RESEARCH

Imaging and Quantitative Assessment of Long Bone Vascularization in the Adult Rat Using Microcomputed Tomography

(2009) Fei Jia et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Development and Validation of a Predictive Bone Fracture Risk Model for Astronauts

(2009) Emily S. Nelson et al.   ANNALS OF BIOMEDICAL ENGINEERING

Musculoskeletal Injuries and Minor Trauma in Space: Incidence and Injury Mechanisms in U.S. Astronauts

(2009) Richard A. Scheuring et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations

(2009) Jeffrey S. Willey et al.   BONE

Exercise in space: human skeletal muscle after 6 months aboard the International Space Station

(2009) Scott Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

Large-scale mRNA analysis of female skeletal muscles during 60 days of bed rest with and without exercise or dietary protein supplementation as countermeasures

(2009) A. Chopard et al.   PHYSIOLOGICAL GENOMICS

Musculoskeletal Changes in Mice from 20–50 cGy of Simulated Galactic Cosmic Rays

(2009) Eric R. Bandstra et al.   RADIATION RESEARCH

Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest

(2009) Nilsson Holguin et al.   Spine Journal

WISE-2005: Supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity

(2008) Scott M. Smith et al.   BONE

Reduction in proximal femoral strength due to long-duration spaceflight

(2008) J.H. Keyak et al.   BONE

Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation

(2008) Daila S. Gridley et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Molecular biomarkers monitoring human skeletal muscle fibres and microvasculature following long-term bed rest with and without countermeasures

(2008) M. Salanova et al.   JOURNAL OF ANATOMY

Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioning

(2008) Michael D. Delp   JOURNAL OF APPLIED PHYSIOLOGY

Transcriptional Analysis of Normal Human Fibroblast Responses to Microgravity Stress

(2008) Yongqing Liu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Human soleus single muscle fiber function with exercise or nutrition countermeasures during 60 days of bed rest

(2007) Scott Trappe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY