Leucine partially protects muscle mass and function during bed rest in middle-aged adults1,2

Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males

(2015) Benjamin T. Wall et al.   EXPERIMENTAL GERONTOLOGY

CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis

(2014) Michael B. Reid et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis

(2014) Stuart M. Phillips et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bed Rest Promotes Reductions in Walking Speed, Functional Parameters, and Aerobic Fitness in Older, Healthy Adults

(2014) R. H. Coker et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells

(2013) Roger A. Vaughan et al.   AMINO ACIDS

Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

(2013) Nicolaas E.P. Deutz et al.   CLINICAL NUTRITION

Dietary protein and muscle in older persons

(2013) Douglas Paddon-Jones et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Acute Skeletal Muscle Wasting in Critical Illness

(2013) Zudin A. Puthucheary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nutritional strategies to attenuate muscle disuse atrophy

(2013) Benjamin T Wall et al.   NUTRITION REVIEWS

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

(2012) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein

(2012) Shanon L. Casperson et al.   CLINICAL NUTRITION

Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats

(2012) Layne E Norton et al.   Nutrition & Metabolism

Does Protein Supplementation Prevent Muscle Disuse Atrophy and Loss of Strength?

(2011) T. Peter Stein et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Artificial gravity training reduces bed rest-induced cardiovascular deconditioning

(2011) Michael B. Stenger et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Dietary protein intake in community-dwelling, frail, and institutionalized elderly people: scope for improvement

(2011) Michael Tieland et al.   EUROPEAN JOURNAL OF NUTRITION

Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

(2011) Marika Leenders et al.   JOURNAL OF NUTRITION

Functional Impact of 10 Days of Bed Rest in Healthy Older Adults

(2011) P. Kortebein et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy

(2010) Elisa I. Glover et al.   Applied Physiology Nutrition and Metabolism

Effects of 3 days unloading on molecular regulators of muscle size in humans

(2010) T. Gustafsson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women

(2010) Erin L. Glynn et al.   JOURNAL OF NUTRITION

Ambulatory Activity of Older Adults Hospitalized with Acute Medical Illness

(2010) Steve R. Fisher et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men

(2009) Suzanne Verhoeven et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly

(2009) Arny A. Ferrando et al.   CLINICAL NUTRITION

Protecting muscle mass and function in older adults during bed rest

(2009) Kirk L English et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Exercise in space: human skeletal muscle after 6 months aboard the International Space Station

(2009) Scott Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity

(2009) T. B. Symons et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of aging on human skeletal muscle after immobilization and retraining

(2009) C. Suetta et al.   JOURNAL OF APPLIED PHYSIOLOGY

Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women

(2009) Arkan Abadi et al.   PLoS One

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

(2008) Micah J Drummond et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Skeletal muscle proteolysis in response to short-term unloading in humans

(2008) Per A. Tesch et al.   JOURNAL OF APPLIED PHYSIOLOGY

LBNP exercise protects aerobic capacity and sprint speed of female twins during 30 days of bed rest

(2008) Stuart M. C. Lee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

(2008) Elisa I. Glover et al.   JOURNAL OF PHYSIOLOGY-LONDON