Long-duration bed rest as an analog to microgravity

Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts

(2016) Richard L. Hughson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Muscle and bone, two interconnected tissues

(2015) Camille Tagliaferri et al.   AGEING RESEARCH REVIEWS

Pharmacological diversity among drugs that inhibit bone resorption

(2015) R Graham G Russell   CURRENT OPINION IN PHARMACOLOGY

Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?

(2015) Daniel L. Belavy et al.   EUROPEAN SPINE JOURNAL

Effects of chronic hypergravity: from adaptive to deleterious responses in growing mouse skeleton

(2015) Vasily Gnyubkin et al.   JOURNAL OF APPLIED PHYSIOLOGY

The First 10 Years of Aerobic Exercise Responses to Long-Duration ISS Flights

(2015) Alan D. Moore et al.   Aerospace Medicine and Human Performance

Effects of 60-day head-down bed rest on osteocalcin, glycolipid metabolism and their association with or without resistance training

(2014) Chao Yang et al.   CLINICAL ENDOCRINOLOGY

Bone loss patterns in cortical, subcortical, and trabecular compartments during simulated microgravity

(2014) Tomas Cervinka et al.   JOURNAL OF APPLIED PHYSIOLOGY

Peak exercise oxygen uptake during and following long-duration spaceflight

(2014) Alan D. Moore et al.   JOURNAL OF APPLIED PHYSIOLOGY

The effect of rowing ergometry and resistive exercise on skeletal muscle structure and function during bed rest

(2014) Felix Krainski et al.   JOURNAL OF APPLIED PHYSIOLOGY

WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women

(2014) Stuart M. C. Lee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of Sex and Gender on Adaptation to Space: Musculoskeletal Health

(2014) Lori Ploutz-Snyder et al.   JOURNAL OF WOMENS HEALTH

Muscle Atrophy, Pain, and Damage in Bed Rest Reduced by Resistive (Vibration) Exercise

(2014) TANJA MIOKOVIC et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures

(2013) Laurence Stevens et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Intraocular/Intracranial Pressure Mismatch Hypothesis for Visual Impairment Syndrome in Space

(2013) Li-Fan Zhang et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Fifteen days of microgravity causes growth in calvaria of mice

(2013) Bing Zhang et al.   BONE

Effects of prolonged space flight on human skeletal muscle enzyme and substrate profiles

(2013) R. H. Fitts et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypertrophy in the cervical muscles and thoracic discs in bed rest?

(2013) Daniel L. Belavý et al.   JOURNAL OF APPLIED PHYSIOLOGY

Regulation of male fertility by the bone-derived hormone osteocalcin

(2013) Gerard Karsenty et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight

(2013) A. LeBlanc et al.   OSTEOPOROSIS INTERNATIONAL

Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight

(2012) Alan R. Hargens et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

MECHANISMS IN ENDOCRINOLOGY: The endocrine role of the skeleton: background and clinical evidence

(2012) Verena Schwetz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men

(2012) Guy Trudel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Bone metabolism and nutritional status during 30-day head-down-tilt bed rest

(2012) Jennifer L. L. Morgan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Serum Sclerostin Increases in Healthy Adult Men during Bed Rest

(2012) J. M. Spatz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

(2012) J. L. L. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

(2012) Scott Smith et al.   Nutrients

WISE-2005: Bed-rest induced changes in bone mineral density in women during 60days simulated microgravity

(2011) Gisela Beller et al.   BONE

Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

(2011) A. Krings et al.   BONE

Does Protein Supplementation Prevent Muscle Disuse Atrophy and Loss of Strength?

(2011) T. Peter Stein et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Pathophysiology of bone loss in disuse osteoporosis

(2011) Christian Alexandre et al.   JOINT BONE SPINE

Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest

(2011) Daniel L. Belavý et al.   JOURNAL OF APPLIED PHYSIOLOGY

High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses

(2011) Petra Frings-Meuthen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Trabecular and cortical bone density and architecture in women after 60 days of bed rest using high-resolution pQCT: WISE 2005

(2011) Gabriele Armbrecht et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight

(2011) Thomas H. Mader et al.   OPHTHALMOLOGY

Incomplete Recovery of Lumbar Intervertebral Discs 2 Years After 60-Day Bed Rest

(2011) Daniel L. Belavý et al.   SPINE

The history and importance of aeronautic dentistry

(2011) Balwant Rai et al.   Journal of Oral Science

Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight

(2010) R. Dana Carpenter et al.   ACTA ASTRONAUTICA

Risk of Herniated Nucleus Pulposus Among U.S. Astronauts

(2010) Smith L. Johnston et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Countermeasures against lumbar spine deconditioning in prolonged bed rest: resistive exercise with and without whole body vibration

(2010) Daniel L. Belavý et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cortical osteoclasts are less sensitive to etidronate than trabecular osteoclasts

(2010) Daniel Chappard et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate

(2010) Lisa A. Ruml et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Changes in markers of bone formation and resorption in a bed rest model of weightlessness

(2010) Sandra A. Lueken et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone mineral loss and recovery after 17 weeks of bed rest

(2010) Adrian D. Leblanc et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Vitamin K status in spaceflight and ground-based models of spaceflight

(2010) Sara R Zwart et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres

(2010) R. H. Fitts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest

(2010) D. L. Belavý et al.   OSTEOPOROSIS INTERNATIONAL

Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation

(2010) Manuela Moriggi et al.   PROTEOMICS

Muscle Atrophy and Changes in Spinal Morphology

(2010) Daniel L. Belavý et al.   SPINE

Skeletal Effects of Long-Duration Head-Down Bed Rest

(2009) Elisabeth R. Spector et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Aerobic Exercise Deconditioning and Countermeasures During Bed Rest

(2009) Stuart M.C. Lee et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment

(2009) Jörn Rittweger et al.   BONE

Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

(2009) Jörn Rittweger et al.   BONE

WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women

(2009) Patrick Guinet et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Differential atrophy of the lower-limb musculature during prolonged bed-rest

(2009) Daniel L. Belavý et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review

(2009) Joan Vernikos et al.   GERONTOLOGY

Exercise in space: human skeletal muscle after 6 months aboard the International Space Station

(2009) Scott Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

WISE-2005

(2009) SUZANNE M. SCHNEIDER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Short-term high dietary calcium intake during bedrest has no effect on markers of bone turnover in healthy men

(2009) Natalie Baecker et al.   NUTRITION

Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

(2009) G. Armbrecht et al.   OSTEOPOROSIS INTERNATIONAL

Large-scale mRNA analysis of female skeletal muscles during 60 days of bed rest with and without exercise or dietary protein supplementation as countermeasures

(2009) A. Chopard et al.   PHYSIOLOGICAL GENOMICS

Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight

(2009) Alan R. Hargens et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Myosin and actin content of human skeletal muscle fibers following 35 days bed rest

(2009) E. Borina et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Resistive Simulated Weightbearing Exercise With Whole Body Vibration Reduces Lumbar Spine Deconditioning in Bed-Rest

(2009) Daniel L. Belavý et al.   SPINE

Pathophysiology of Low Back Pain during Exposure to Microgravity

(2008) Jojo V. Sayson et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

WISE-2005: Supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity

(2008) Scott M. Smith et al.   BONE

Recovery of muscle atrophy and bone loss from 90 days bed rest: Results from a one-year follow-up

(2008) J. Rittweger et al.   BONE

Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise

(2008) Atsushi Okada et al.   INTERNATIONAL JOURNAL OF UROLOGY

Development of a low-dose anti-resorptive drug regimen reveals synergistic suppression of bone formation when coupled with disuse

(2008) Shane A.J. Lloyd et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of artificial gravity during bed rest on bone metabolism in humans

(2008) S. M. Smith et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects

(2006) Joseph E. Zerwekh et al.   JOURNAL OF BONE AND MINERAL RESEARCH