Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 109, Issue 6, Pages 1801-1811Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00707.2010
Keywords
magnetic resonance imaging; microgravity; spaceflight; countermeasures; intervertebral disk
Categories
Funding
- German Research Foundation (DFG) [FE 468/5-1]
- European Space Agency [14431/02/NL/SH2]
- German Aerospace Center (DLR) [50WB0720]
- Novotec Medical, Charite Universitatsmedizin Berlin
- Siemens
- Osteomedical Group
- Wyeth Pharma
- Servier Deutschland
- PG, Kubivent
- Seca
- Astra-Zeneka
- General Electric
- Alexander von Humboldt Foundation
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Belavy DL, Armbrecht G, Gast U, Richardson CA, Hides JA, Felsenberg D. Countermeasures against lumbar spine deconditioning in prolonged bed rest: resistive exercise with and without whole body vibration. J Appl Physiol 109: 1801-1811, 2010. First published September 23, 2010; doi: 10.1152/japplphysiol.00707.2010.-To evaluate the effect of short-duration, high-load resistive exercise, with and without whole body vibration on lumbar muscle size, intervertebral disk and spinal morphology changes, and low back pain (LBP) incidence during prolonged bed rest, 24 subjects underwent 60 days of head-down tilt bed rest and performed either resistive vibration exercise (n = 7), resistive exercise only (n = 8), or no exercise (n = 9; 2nd Berlin Bed-Rest Study). Discal and spinal shape was measured from sagittal plane magnetic resonance images. Cross-sectional areas (CSAs) of the multifidus, erector spinae, quadratus lumborum, and psoas were measured on para-axial magnetic resonance images. LBP incidence was assessed with questionnaires at regular intervals. The countermeasures reduced CSA loss in the multifidus, lumbar erector spinae and quadratus lumborum muscles, with greater increases in psoas muscle CSA seen in the countermeasure groups (P <= 0.004). There was little statistical evidence for an additional effect of whole body vibration above resistive exercise alone on these muscle changes. Exercise subjects reported LBP more frequently in the first week of bed rest, but this was only significant in resistive exercise only (P = 0.011 vs. control, resistive vibration exercise vs. control: P = 0.56). No effect of the countermeasures on changes in spinal morphology was seen (P >= 0.22). The results suggest that high-load resistive exercise, with or without whole body vibration, performed 3 days/wk can reduce lumbar muscle atrophy, but further countermeasure optimization is required.
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