Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

(2017) Muhammet Ay et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Dysfunction during the Early Stages of Excitotoxic Spinal Motor Neuron Degeneration in Vivo

(2016) Luz Diana Santa-Cruz et al.   ACS Chemical Neuroscience

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease

(2016) Tiziana Bonifacino et al.   NEUROBIOLOGY OF DISEASE

Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo

(2016) Uri Nimrod Ramírez-Jarquín et al.   NEUROSCIENCE

Motor Alterations Induced by Chronic 4-Aminopyridine Infusion in the Spinal Cord In vivo: Role of Glutamate and GABA Receptors

(2016) Rafael Lazo-Gómez et al.   Frontiers in Neuroscience

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment

(2015) Minghai Zhou et al.   BRAIN

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection

(2015) Luis Leyton et al.   VIRUS RESEARCH

Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity

(2015) Li-Nan Zhang et al.   Advances in Clinical and Experimental Medicine

Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates

(2015) Citlalli Netzahualcoyotzi et al.   Acta Neuropathologica Communications

Role of Energy Metabolic Deficits and Oxidative Stress in Excitotoxic Spinal Motor Neuron Degeneration in Vivo

(2014) Luz Diana Santa-Cruz et al.   ASN Neuro

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

(2014) Pouria Moshayedi et al.   BIOMATERIALS

Effects of flavonoid quercetin on survival of motor neuron gene expression

(2014) Gözde Uzunallı et al.   CELL BIOLOGY INTERNATIONAL

Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

(2014) Yi Cheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways

(2014) C Valle et al.   Cell Death & Disease

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

(2014) Elena Sidorova-Darmos et al.   Frontiers in Aging Neuroscience

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

(2014) Seiji Watanabe et al.   Molecular Brain

Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro

(2013) Shengjun Wang et al.   BRAIN RESEARCH

Protective effects of resveratrol on glutamate-induced damages in murine brain cultures

(2013) Rudolf Moldzio et al.   JOURNAL OF NEURAL TRANSMISSION

Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

(2013) Vincent B. Owona Ayissi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death

(2013) Kyung-Sik Song et al.   Pharmacognosy Magazine

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Delayed Administration of VEGF Rescues Spinal Motor Neurons from Death with a Short Effective Time Frame in Excitotoxic Experimental Models in Vivo

(2012) Luis B Tovar-y-Romo et al.   ASN Neuro

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease

(2012) M. A. Lim et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?

(2012) Sonja Körner et al.   Neurodegenerative Diseases

Lack of resveratrol neuroprotection in developing rats treated with kainic acid

(2012) L.K. Friedman et al.   NEUROSCIENCE

The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia

(2011) Anand Kumar Pandey et al.   BRAIN RESEARCH

Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

(2011) Jae Chul Lee et al.   BRAIN RESEARCH

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis

(2011) Jing Wang et al.   NEUROSCIENCE LETTERS

Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems

(2010) Sherry M. Zakhary et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Preventing NAD+ Depletion Protects Neurons against Excitotoxicity

(2010) Dong Liu et al.   Annals of the New York Academy of Sciences

Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis

(2010) Marco Milanese et al.   JOURNAL OF NEUROCHEMISTRY

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Resveratrol is neuroprotective because it is not a direct activator of Sirt1—A hypothesis

(2009) Bor Luen Tang   BRAIN RESEARCH BULLETIN

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis

(2009) Luis B Tovar-y-Romo et al.   Molecular Neurodegeneration

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

Quercetin, kaempferol and biapigenin fromhypericum perforatum are neuroprotective against excitotoxic insults

(2009) Bruno Silva et al.   NEUROTOXICITY RESEARCH

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism