The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

Mechanism of Voltage Gating in Potassium Channels

(2012) M. O. Jensen et al.   SCIENCE

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

(2011) Ping-zheng Zhou et al.   ACTA PHARMACOLOGICA SINICA

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Ezogabine (retigabine)

(2011) Carl E. Stafstrom et al.   NATURE REVIEWS DRUG DISCOVERY

In Search of a Consensus Model of the Resting State of a Voltage-Sensing Domain

(2011) Ernesto Vargas et al.   NEURON

Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions

(2010) Zhaobing Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

POVME: An algorithm for measuring binding-pocket volumes

(2010) Jacob D. Durrant et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

(2010) Matthew Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1

(2010) I Scott Ramsey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

(2010) A. Peretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

(2009) Karen Padilla et al.   NEUROSCIENCE LETTERS

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

(2009) M. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels

(2009) Seok-Yong Lee et al.   PLOS BIOLOGY

Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

(2008) X. Xu et al.   MOLECULAR PHARMACOLOGY

Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers

(2008) Q. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds

(2008) Q XIONG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES