Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing

Oxidative Stress and Autophagic Alteration in Brainstem of SOD1-G93A Mouse Model of ALS

(2014) Ting An et al.   MOLECULAR NEUROBIOLOGY

Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair

(2014) Melike Çağlayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

(2014) Meryem Alagoz et al.   PLoS One

The role of TDP1 and APTX in mitochondrial DNA repair

(2013) Martin Meagher et al.   BIOCHIMIE

Chtop is a component of the dynamic TREX mRNA export complex

(2013) Chung-Te Chang et al.   EMBO JOURNAL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

(2013) Zhong-Wei Zhou et al.   PLoS Genetics

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

(2012) Vidisha Tripathi et al.   MOLECULAR BIOLOGY OF THE CELL

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

(2012) Jessica J.R. Hudson et al.   Nature Communications

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

(2011) Violetta Soura et al.   BIOCHEMICAL JOURNAL

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis

(2011) A. Acevedo-Arozena et al.   Disease Models & Mechanisms

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

Aprataxin localizes to mitochondria and preserves mitochondrial function

(2011) P. Sykora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS

(2010) Livea F. Barbosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage

(2010) Shih-Chieh Chiang et al.   CELL CYCLE

Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5′ end processing during base excision repair

(2010) James M. Daley et al.   DNA REPAIR

Role of senataxin in DNA damage and telomeric stability

(2010) Andrea De Amicis et al.   DNA REPAIR

Short-patch single-strand break repair in ataxia oculomotor apraxia-1

(2009) John J. Reynolds et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

(2009) Sherif F. El-Khamisy et al.   DNA REPAIR

Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage

(2009) Janelle L. Harris et al.   HUMAN MOLECULAR GENETICS

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

(2009) George A. Garinis et al.   NATURE CELL BIOLOGY

The antioxidant properties of serum albumin

(2008) Marjolaine Roche et al.   FEBS LETTERS

Molecular Mechanism of DNA Deadenylation by the Neurological Disease Protein Aprataxin

(2008) Ulrich Rass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS

(2008) Nirit Lev et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1

(2008) J. J. Reynolds et al.   MOLECULAR AND CELLULAR BIOLOGY