ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

(2014) Emil R. Unanue   Annual Review of Immunology

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

(2013) Boris Calderon et al.   CURRENT OPINION IN IMMUNOLOGY

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice

(2013) R. L. Baker et al.   JOURNAL OF IMMUNOLOGY

ZnT8-Specific CD4+ T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults

(2013) Daisuke Chujo et al.   PLoS One

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes

(2012) Sofie Ingemansson et al.   AUTOIMMUNITY

Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays

(2012) Xiangmei Wu et al.   AUTOIMMUNITY

Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes

(2012) Mette K. Andersen et al.   AUTOIMMUNITY

ZnT8 Is a Major CD8+ T Cell-Recognized Autoantigen in Pediatric Type 1 Diabetes

(2012) E. Enee et al.   DIABETES

Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients

(2012) M. Scotto et al.   DIABETOLOGIA

Antigenicity and Epitope Specificity of ZnT8 Autoantibodies in Type 1 Diabetes

(2012) H. Skärstrand et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening

(2011) C. Tiberti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

(2011) Carolin Daniel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8

(2011) M. Dang et al.   JOURNAL OF IMMUNOLOGY

Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response

(2011) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Quantitative proteomic analysis of single pancreatic islets

(2009) Leonie F. Waanders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Weak Proinsulin Peptide-Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

(2008) M. G. Levisetti et al.   DIABETES

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

(2008) J. M. Wenzlau et al.   DIABETES

Characterization of the Mouse Pancreatic Islet Proteome and Comparative Analysis with Other Mouse Tissues

(2008) Vladislav A. Petyuk et al.   JOURNAL OF PROTEOME RESEARCH

Dendritic cells in islets of Langerhans constitutively present   cell-derived peptides bound to their class II MHC molecules

(2008) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA