E2F1, a Novel Regulator of Metabolism

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma

(2017) Lucille Morzyglod et al.   HEPATOLOGY

Anti-PCSK9 antibodies for hypercholesterolaemia: Overview of clinical data and implications for primary care

(2017) Olivier S. Descamps et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

(2017) Lindsey N. Kent et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin

(2017) Laura Chirivella et al.   STEM CELLS

ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype

(2017) Yulia Haim et al.   Molecular Metabolism

Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?

(2017) Sarah-Maria Fendt   Frontiers in Endocrinology

Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells

(2016) Kazunori Mori et al.   CANCER SCIENCE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Obesity and Cancer: The Oil that Feeds the Flame

(2016) Joan Font-Burgada et al.   Cell Metabolism

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

(2016) Chia-Lin Chen et al.   Cell Metabolism

Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD

(2016) Helen L. Reeves et al.   DIGESTIVE DISEASES AND SCIENCES

RB1: a prototype tumor suppressor and an enigma

(2016) Nicholas J. Dyson   GENES & DEVELOPMENT

Obesity and Cancer Mechanisms: Cancer Metabolism

(2016) Benjamin D. Hopkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice

(2016) Youngshim Choi et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Correction to: ‘The Warburg Effect: How Does it Benefit Cancer Cells?’

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

E2F function in muscle growth is necessary and sufficient for viability in Drosophila

(2016) Maria Paula Zappia et al.   Nature Communications

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis

(2016) Ling-Yu Wang et al.   Cell Reports

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

(2016) Jorge Franco et al.   Cell Reports

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton’s Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants

(2016) Peck Yean Tan et al.   PLoS One

Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

(2015) Yulia Haim et al.   Autophagy

Emerging Links between E2F Control and Mitochondrial Function

(2015) E. V. Benevolenskaya et al.   CANCER RESEARCH

Cell cycle regulation of mitochondrial function

(2015) Isabel C Lopez-Mejia et al.   CURRENT OPINION IN CELL BIOLOGY

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

(2015) Brandon N. Nicolay et al.   GENES & DEVELOPMENT

Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex

(2015) Wuming Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cezanne regulates E2F1-dependent HIF2  expression

(2015) S. Moniz et al.   JOURNAL OF CELL SCIENCE

Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells

(2015) Petar D. Petrov et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CDK4 is an essential insulin effector in adipocytes

(2015) Sylviane Lagarrigue et al.   JOURNAL OF CLINICAL INVESTIGATION

E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis

(2015) Pierre-Damien Denechaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression

(2015) Amy Tarangelo et al.   Nature Communications

E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1

(2015) Kun Wang et al.   Nature Communications

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

(2015) Minghui Wu et al.   Oncotarget

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

(2015) Nathalie Meo-Evoli et al.   Oncotarget

E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression

(2014) Min Wu et al.   CARDIOVASCULAR RESEARCH

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network

(2014) Yuxia Zhang et al.   HEPATOLOGY

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

Decreased RB1 mRNA, Protein, and Activity Reflect Obesity-Induced Altered Adipogenic Capacity in Human Adipose Tissue

(2013) J. M. Moreno-Navarrete et al.   DIABETES

pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location

(2013) Zhonglei Lu et al.   EMBO JOURNAL

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

(2013) Chong Wee Liew et al.   NATURE MEDICINE

The role of the E2F1 transcription factor in the innate immune response to systemic LPS

(2012) Laura A. Warg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding

(2012) Liyan Zhang et al.   FEBS LETTERS

E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism

(2012) Emilie Blanchet et al.   HUMAN MOLECULAR GENETICS

The RIP140 Gene Is a Transcriptional Target of E2F1

(2012) Aurélie Docquier et al.   PLoS One

ROS Production Is Essential for the Apoptotic Function of E2F1 in Pheochromocytoma and Neuroblastoma Cell Lines

(2012) Lilia Espada et al.   PLoS One

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice

(2011) Soyoung Kim et al.   BIOCHEMICAL PHARMACOLOGY

The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors

(2011) S. Y. Kim et al.   DEVELOPMENT

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift

(2010) Giovanni Ciavarra et al.   JOURNAL OF CELL BIOLOGY

Oxidative status of muscle is determined by p107 regulation of PGC-1α

(2010) Anthony Scimè et al.   JOURNAL OF CELL BIOLOGY

Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma

(2010) B Bhatia et al.   ONCOGENE

The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion

(2010) Lluis Fajas et al.   Islets

Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice

(2009) Josep Mercader et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The CDK4–pRB–E2F1 pathway controls insulin secretion

(2009) Jean-Sébastien Annicotte et al.   NATURE CELL BIOLOGY

ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells

(2009) Z. Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live or Let Die: E2F1 and PI3K Pathways Intersect to Make Life or Death Decisions

(2008) Brian David Dynlacht   CANCER CELL

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

(2008) V. G. Sankaran et al.   GENES & DEVELOPMENT

Regulation of the PDK4 Isozyme by the Rb-E2F1 Complex

(2008) Michael C. F. Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2F1 regulates autophagy and the transcription of autophagy genes

(2008) S Polager et al.   ONCOGENE