Frontiers in Toxicogenomics in the Twenty-First Century—the Grand Challenge: To Understand How the Genome and Epigenome Interact with the Toxic Environment at the Single-Cell, Whole-Organism, and Multi-Generational Level

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

(2017) Wanlu Cao et al.   GASTROENTEROLOGY

Spectroscopic investigation of the effects of aqueous-phase prepared CdTe quantum dots on protein hemoglobin at the molecular level

(2017) Dandan Guo et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A miniaturized electrochemical toxicity biosensor based on graphene oxide quantum dots/carboxylated carbon nanotubes for assessment of priority pollutants

(2017) Xiaolin Zhu et al.   JOURNAL OF HAZARDOUS MATERIALS

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression

(2017) Christopher R. Dorsett et al.   JOURNAL OF NEUROTRAUMA

SAFE trial: an ongoing randomized clinical study to assess the role of cardiotoxicity prevention in breast cancer patients treated with anthracyclines with or without trastuzumab

(2017) Icro Meattini et al.   MEDICAL ONCOLOGY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

(2017) Erica K. Brockmeier et al.   TOXICOLOGICAL SCIENCES

Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure

(2017) Jung-hee Lim et al.   TOXICOLOGY IN VITRO

Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time

(2017) Dimitry Ofengeim et al.   TRENDS IN MOLECULAR MEDICINE

Fetal and postnatal metal dysregulation in autism

(2017) Manish Arora et al.   Nature Communications

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation

(2017) Hisham Mohammed et al.   Cell Reports

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

(2017) Shanshan Zhou et al.   PLoS Genetics

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

Exosomes in the Diseased Brain: First Insights from In vivo Studies

(2017) Efrat Levy   Frontiers in Neuroscience

Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties

(2017) Yoni Baert et al.   Stem Cell Reports

Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic Fingerprint

(2017) Sören Müller et al.   Frontiers in Genetics

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish

(2017) Michael J. Carvan et al.   PLoS One

High-resolution 3D imaging of whole organ after clearing: taking a new look at the zebrafish testis

(2017) Maxence Frétaud et al.   Scientific Reports

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster

(2016) Shanshan Zhou et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Trends in the characteristics, dose-limiting toxicities and efficacy of phase I oncology trials: The Cancer Research UK experience

(2016) Han Hsi Wong et al.   EUROPEAN JOURNAL OF CANCER

Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers

(2016) A. Modabbernia et al.   EUROPEAN PSYCHIATRY

Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors

(2016) Jennifer Yang et al.   NUCLEIC ACIDS RESEARCH

Management of Adverse Events Following Treatment With Anti-Programmed Death-1 Agents

(2016) Jeffrey S. Weber et al.   ONCOLOGIST

Single-cell RNA-sequencing: The future of genome biology is now

(2016) Simone Picelli   RNA Biology

The Microbiome

(2016) Ellen K. Silbergeld   TOXICOLOGIC PATHOLOGY

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

(2016) Jennifer E. Cropley et al.   Molecular Metabolism

2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues

(2016) Erdogan Taskesen et al.   PLoS One

Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture

(2016) Thomas Ingersoll et al.   PLoS One

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System

(2015) Joshua G. Hunsberger et al.   STEM CELLS AND DEVELOPMENT

Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes

(2015) Philippe Beauchamp et al.   TISSUE ENGINEERING PART C-METHODS

Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

(2015) Arko Sen et al.   Scientific Reports

Nature, nurture and epigenetics

(2014) David Crews et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Transgenerational inheritance of prenatal obesogen exposure

(2014) Amanda S. Janesick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model

(2014) Joseph A. Caruso et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transgenerational Inheritance of Increased Fat Depot Size, Stem Cell Reprogramming, and Hepatic Steatosis Elicited by Prenatal Exposure to the Obesogen Tributyltin in Mice

(2013) Raquel Chamorro-García et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A New, Straightforward Ex Vivo Organoid Bladder Mucosal Model for Preclinical Research

(2013) Dick A.W. Janssen et al.   JOURNAL OF UROLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

(2012) Anna I. Astashkina et al.   BIOMATERIALS

Functional Genomics- and Network-driven Systems Biology Approaches for Pharmacogenomics and Toxicogenomics

(2012) Xia Yang et al.   CURRENT DRUG METABOLISM

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift

(2012) Pablo Cingolani et al.   Frontiers in Genetics

Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century

(2011) Holly M. Mortensen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data

(2010) R. Pique-Regi et al.   GENOME RESEARCH

Direct detection of DNA methylation during single-molecule, real-time sequencing

(2010) Benjamin A Flusberg et al.   NATURE METHODS

Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome

(2010) Carlos Guerrero-Bosagna et al.   PLoS One

Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead

(2009) Douglas M. Ruden et al.   NEUROTOXICOLOGY

GADD45a-GFP GreenScreen HC genotoxicity screening assay

(2008) Richard M Walmsley   Expert Opinion on Drug Metabolism & Toxicology