Recent Advances in Developing Antiviral Therapies for Respiratory Syncytial Virus

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase

(2016) Rachel Fearns et al.   ANTIVIRAL RESEARCH

Structure-guided design of small-molecule therapeutics against RSV disease

(2016) Robert Cox et al.   Expert Opinion on Drug Discovery

ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients

(2016) Jens Gottlieb et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Aerosolized ribavirin: the most expensive drug for pneumonia

(2016) R.F. Chemaly et al.   Transplant Infectious Disease

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

(2016) Xiufang Zheng et al.   ACS Medicinal Chemistry Letters

Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication

(2016) B. Bailly et al.   Scientific Reports

Effect of Oral JNJ-53718678 (JNJ-678) on Disease Severity in Healthy Adult Volunteers Experimentally Inoculated With Live Respiratory Syncytial Virus (RSV): A Placebo-Controlled Challenge Study

(2016) Samuel Israel et al.   Open Forum Infectious Diseases

Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection

(2015) Laurent Detalle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzimidazole analogs inhibit respiratory syncytial virus G protein function

(2015) Carrie W. Evans et al.   ANTIVIRAL RESEARCH

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen

(2015) Valerie A. Laganas et al.   ANTIVIRAL RESEARCH

In silico structure-based design and synthesis of novel anti-RSV compounds

(2015) Michela Cancellieri et al.   ANTIVIRAL RESEARCH

Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

(2015) Michael O. Clarke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

(2015) Silas Bond et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

(2015) Silas Bond et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells

(2015) Tatiana Chirkova et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study

(2015) Richard L. Mackman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

(2015) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

(2015) Mohamed Ouizougun-Oubari et al.   JOURNAL OF VIROLOGY

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

(2015) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

(2015) Song Feng et al.   ACS Medicinal Chemistry Letters

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

(2015) Jerome Deval et al.   PLoS Pathogens

Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures

(2015) Sara M. Johnson et al.   PLoS Pathogens

CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner

(2015) Kwang-Il Jeong et al.   PLoS One

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

(2015) Gabriela Ispas et al.   PLoS One

Characterization of a Respiratory Syncytial Virus L Protein Inhibitor

(2014) Choi-Lai Tiong-Yip et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

(2014) SreeRupa Challa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity

(2014) Daljit S. Matharu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study

(2014) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

(2014) S. J. Tanner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors

(2014) D. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a high-throughput replicon assay for the identification of respiratory syncytial virus inhibitors

(2013) Choi-Lai Tiong-Yip et al.   ANTIVIRAL RESEARCH

Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor

(2013) Hui Xiong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness

(2013) Octavio Ramilo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Development of a simple, rapid, sensitive, high-throughput luciferase reporter based microneutralization test for measurement of virus neutralizing antibodies following Respiratory Syncytial Virus vaccination and infection

(2013) Sandra Fuentes et al.   VACCINE

Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection

(2012) Rachel J. Derscheid et al.   Viruses-Basel

Animal models of human respiratory syncytial virus disease

(2011) Reinout A. Bem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An evaluation of the emerging interventions against Respiratory Syncytial Virus (RSV)-associated acute lower respiratory infections in children

(2011) Harish Nair et al.   BMC PUBLIC HEALTH

Multiple Functional Domains and Complexes of the Two Nonstructural Proteins of Human Respiratory Syncytial Virus Contribute to Interferon Suppression and Cellular Location

(2011) S. Swedan et al.   JOURNAL OF VIROLOGY

Respiratory Viral Infections in Hematopoietic Stem Cell and Solid Organ Transplant Recipients

(2011) S. Weigt et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus

(2010) John P. DeVincenzo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of respiratory syncytial virus by zinc finger reactive compounds

(2010) Marina S Boukhvalova et al.   Virology Journal

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

(2009) R. Alvarez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cotton rat model of respiratory viral infections

(2009) Marina S. Boukhvalova et al.   BIOLOGICALS

The Respiratory Syncytial Virus M2-1 Protein Forms Tetramers and Interacts with RNA and P in a Competitive Manner

(2009) T.-L. Tran et al.   JOURNAL OF VIROLOGY

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Motavizumab, a Humanized, Enhanced-Potency Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus Infection in At-Risk Children

(2009) Katia Abarca et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial

(2009) X. Carbonell-Estrany et al.   PEDIATRICS

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

(2008) Jean-François Bonfanti et al.   JOURNAL OF MEDICINAL CHEMISTRY