Structure-guided design of small-molecule therapeutics against RSV disease

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen

(2015) Valerie A. Laganas et al.   ANTIVIRAL RESEARCH

In silico structure-based design and synthesis of novel anti-RSV compounds

(2015) Michela Cancellieri et al.   ANTIVIRAL RESEARCH

Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens

(2015) Dan Yan et al.   BIOCHEMISTRY

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

(2015) Bo Liang et al.   CELL

Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study

(2015) Richard L. Mackman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

(2015) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

(2015) Mohamed Ouizougun-Oubari et al.   JOURNAL OF VIROLOGY

Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein

(2015) Marie Galloux et al.   JOURNAL OF VIROLOGY

Dimerization of Matrix Protein Is Required for Budding of Respiratory Syncytial Virus

(2015) Andreas Förster et al.   JOURNAL OF VIROLOGY

Molecular mechanism of respiratory syncytial virus fusion inhibitors

(2015) Michael B Battles et al.   Nature Chemical Biology

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

(2015) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

X-ray structure and activities of an essential Mononegavirales L-protein domain

(2015) Guido C. Paesen et al.   Nature Communications

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

(2015) Jerome Deval et al.   PLoS Pathogens

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

(2015) Gabriela Ispas et al.   PLoS One

Characterization of a Respiratory Syncytial Virus L Protein Inhibitor

(2014) Choi-Lai Tiong-Yip et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

(2014) SreeRupa Challa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity

(2014) Daljit S. Matharu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone

(2014) Filip Yabukarski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study

(2014) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein

(2014) Robert Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

(2014) S. J. Tanner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors

(2014) D. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain

(2014) M. A. Brindley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LATE BREAKER ABSTRACTS

(2014) J. Devincenzo et al.   Open Forum Infectious Diseases

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

High Morbidity and Mortality in Adults Hospitalized for Respiratory Syncytial Virus Infections

(2013) N. Lee et al.   CLINICAL INFECTIOUS DISEASES

iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein–protein interactions

(2013) Céline M. Labbé et al.   DRUG DISCOVERY TODAY

Hepatitis C therapy with HCV NS5B polymerase inhibitors

(2013) Vincent Soriano et al.   EXPERT OPINION ON PHARMACOTHERAPY

The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid

(2013) S. E. Bakker et al.   JOURNAL OF GENERAL VIROLOGY

Structural and Functional Characterization of the Mumps Virus Phosphoprotein

(2013) R. Cox et al.   JOURNAL OF VIROLOGY

Crystal Structure of the Nipah Virus Phosphoprotein Tetramerization Domain

(2013) J. F. Bruhn et al.   JOURNAL OF VIROLOGY

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

(2013) Cedric Leyrat et al.   PLoS One

Architecture of respiratory syncytial virus revealed by electron cryotomography

(2013) L. Liljeroos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells

(2013) Andressa P. Oliveira et al.   VIRUS RESEARCH

Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability

(2013) Iris Usach et al.   Journal of the International AIDS Society

Host Cell Entry of Respiratory Syncytial Virus Involves Macropinocytosis Followed by Proteolytic Activation of the F Protein

(2013) Magdalena Anna Krzyzaniak et al.   PLoS Pathogens

Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

(2012) Matthew C. Smith et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Independent Structural Domains inParamyxovirusPolymerase Protein

(2012) Melanie Dochow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Viral Phosphoprotein Binding Site on the Surface of the Respiratory Syncytial Nucleoprotein

(2012) Marie Galloux et al.   JOURNAL OF VIROLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions

(2012) Marie Jeanne Basse et al.   NUCLEIC ACIDS RESEARCH

Structure and Functional Analysis of the RNA- and Viral Phosphoprotein-Binding Domain of Respiratory Syncytial Virus M2-1 Protein

(2012) Marie-Lise Blondot et al.   PLoS Pathogens

Cost-effectiveness analysis of palivizumab among pre-term infant populations covered by Medicaid in the United States

(2012) Leonard B. Weiner et al.   JOURNAL OF MEDICAL ECONOMICS

Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form

(2011) K. El Omari et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus

(2011) See Ven Lim et al.   BMC BIOINFORMATICS

Respiratory Syncytial Virus Load, Viral Dynamics, and Disease Severity in Previously Healthy Naturally Infected Children

(2011) Chadi M. El Saleeby et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c Mice

(2011) K. L. Stokes et al.   JOURNAL OF VIROLOGY

Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus

(2010) John P. DeVincenzo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Protein-protein docking benchmark version 4.0

(2010) Howook Hwang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The RNA capping machinery as an anti-infective target

(2010) Moheshwarnath Issur et al.   Wiley Interdisciplinary Reviews-RNA

Target Analysis of the Experimental Measles Therapeutic AS-136A

(2009) J.-J. Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database

(2009) Alícia P. Higueruelo et al.   Chemical Biology & Drug Design

RNA triphosphatase and guanylyl transferase activities are associated with the RNA polymerase protein L of rinderpest virus

(2009) M. Gopinath et al.   JOURNAL OF GENERAL VIROLOGY

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein

(2009) D. Roymans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

(2009) R. G. Tawar et al.   SCIENCE

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

(2008) Jean-François Bonfanti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Sendai Virus L Protein Amino Acid Residues Affecting Viral mRNA Cap Methylation

(2008) A. M. Murphy et al.   JOURNAL OF VIROLOGY