Langerhans Cells—Programmed by the Epidermis

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

(2017) A Schridde et al.   Mucosal Immunology

Langerhans Cells – The Macrophage in Dendritic Cell Clothing

(2017) Thomas Doebel et al.   TRENDS IN IMMUNOLOGY

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

(2017) C. C. Bain et al.   Nature Communications

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

(2017) Marta E. Polak et al.   Scientific Reports

TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

(2016) X. Zhang et al.   ALLERGY

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget disease by receptor activator of nuclear factor kappa B (RANK) ligand/RANK pathways

(2016) T. Fujimura et al.   BRITISH JOURNAL OF DERMATOLOGY

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1+ DCs in mouse and human and distinguishes them from Langerhans cells

(2016) Sabrina Carpentier et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

(2016) Carla M. S. Ribeiro et al.   NATURE

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Langerhans cell precursors acquire RANK/CD265 in prenatal human skin

(2015) Alice Schöppl et al.   ACTA HISTOCHEMICA

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells

(2015) Maxim N. Artyomov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutaneous RANK–RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis

(2015) Lars Klenner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Establishing and maintaining the Langerhans cell network

(2015) Michaël Chopin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Relay of Herpes Simplex Virus between Langerhans Cells and Dermal Dendritic Cells in Human Skin

(2015) Min Kim et al.   PLoS Pathogens

Functional association networks as priors for gene regulatory network inference

(2014) Matthew E. Studham et al.   BIOINFORMATICS

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7‐dependent manner

(2014) Merav Cohen et al.   EMBO JOURNAL

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance

(2014) V. Flacher et al.   EMBO Molecular Medicine

Epidermal and Dermal Dendritic Cells Display Differential Activation and Migratory Behavior While Sharing the Ability to Stimulate CD4+ T Cell Proliferation In Vivo

(2014) E. Shklovskaya et al.   JOURNAL OF IMMUNOLOGY

Epidermal Receptor Activator of NF- B Ligand Controls Langerhans Cells Numbers and Proliferation

(2014) J.-B. O. Barbaroux et al.   JOURNAL OF IMMUNOLOGY

Gene regulatory networks in the immune system

(2014) Harinder Singh et al.   TRENDS IN IMMUNOLOGY

Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments

(2014) Dorothée Duluc et al.   Genome Medicine

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation

(2013) Thien-Phong Vu Manh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Multicolor fate mapping of Langerhans cell homeostasis

(2013) Clément Ghigo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks

(2013) Michaël Chopin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting of Autoantigens to DEC205+ Dendritic Cells In Vivo Suppresses Experimental Allergic Encephalomyelitis in Mice

(2013) S. Ring et al.   JOURNAL OF IMMUNOLOGY

Langerhans Cells Favor Skin Flora Tolerance through Limited Presentation of Bacterial Antigens and Induction of Regulatory T Cells

(2013) Angelic M.G. van der Aar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

β-Catenin Promotes the Differentiation of Epidermal Langerhans Dendritic Cells

(2013) Nighat Yasmin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

(2013) Louise Newell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct Molecular Signature of Human Skin Langerhans Cells Denotes Critical Differences in Cutaneous Dendritic Cell Immune Regulation

(2013) Marta E. Polak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

(2013) Bryan Vander Lugt et al.   NATURE IMMUNOLOGY

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

(2013) Jesse W. Williams et al.   Nature Communications

The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming

(2012) J. Banchereau et al.   BLOOD

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells

(2012) C. Hutter et al.   BLOOD

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation

(2012) Kristin Seré et al.   IMMUNITY

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells

(2012) Julien Seneschal et al.   IMMUNITY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells

(2012) A. N. Harman et al.   JOURNAL OF IMMUNOLOGY

IRF4 Promotes Cutaneous Dendritic Cell Migration to Lymph Nodes during Homeostasis and Inflammation

(2012) S. Bajana et al.   JOURNAL OF IMMUNOLOGY

Phenotypic Characterization of Leukocytes in Prenatal Human Dermis

(2012) Christopher Schuster et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD70–CD27 Interaction Augments CD8+ T-Cell Activation by Human Epidermal Langerhans Cells

(2012) Marta E. Polak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TGFβ/Smad3 Signal Pathway Is Not Required for Epidermal Langerhans Cell Development

(2012) Ying-Ping Xu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Compensatory dendritic cell development mediated by BATF–IRF interactions

(2012) Roxane Tussiwand et al.   NATURE

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Positive Regulatory Domain I (PRDM1) and IRF8/PU.1 Counter-regulate MHC Class II Transactivator (CIITA) Expression during Dendritic Cell Maturation

(2011) Matthew A. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight Control of STAT5 Activity Determines Human CD34-Derived Interstitial Dendritic Cell and Langerhans Cell Development

(2011) L. van de Laar et al.   JOURNAL OF IMMUNOLOGY

Human Epidermal Langerhans Cells Replenish Skin Xenografts and Are Depleted by Alloreactive T Cells In Vivo

(2011) J. Hemmerling et al.   JOURNAL OF IMMUNOLOGY

Conditional Deletion of TGF-βR1 Using Langerin-Cre Mice Results in Langerhans Cell Deficiency and Reduced Contact Hypersensitivity

(2011) Sonja P. Zahner et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8+ T Cell Responses

(2011) A. M. G. van der Aar et al.   JOURNAL OF IMMUNOLOGY

Whole-Body UVB Irradiation during Allogeneic Hematopoietic Cell Transplantation Is Safe and Decreases Acute Graft-versus-Host Disease

(2011) Marina Kreutz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased MAPK and NF-κB expression of Langerhans cells is dependent on TLR2 and TLR4, and increased IRF-3 expression is partially dependent on TLR4 following UV exposure

(2011) Zhigang Bi   Molecular Medicine Reports

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Specificity of Innate Immune Responses Is Enforced by Repression of Interferon Response Elements by NF- B p50

(2011) C. S. Cheng et al.   Science Signaling

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

Understanding the temporal codes of intra-cellular signals

(2010) Marcelo Behar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Antigen-specific immunotherapy of autoimmune and allergic diseases

(2010) Catherine A Sabatos-Peyton et al.   CURRENT OPINION IN IMMUNOLOGY

Self-renewal capacity of human epidermal Langerhans cells: observations made on a composite tissue allograft

(2010) Jean Kanitakis et al.   EXPERIMENTAL DERMATOLOGY

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

(2010) Neil A. Mabbott et al.   IMMUNOBIOLOGY

Langerhans cells: critical regulators of skin immunity?

(2010) Björn E Clausen et al.   IMMUNOLOGY AND CELL BIOLOGY

Ontogeny and homeostasis of Langerhans cells

(2010) Florent Ginhoux et al.   IMMUNOLOGY AND CELL BIOLOGY

Langerin functions as an antiviral receptor on Langerhans cells

(2010) Michiel van der Vlist et al.   IMMUNOLOGY AND CELL BIOLOGY

Herpes Simplex Virus Infects Skin    T Cells before Langerhans Cells and Impedes Migration of Infected Langerhans Cells by Inducing Apoptosis and Blocking E-Cadherin Downregulation

(2010) F. K. Puttur et al.   JOURNAL OF IMMUNOLOGY

TGF-  Is Required To Maintain the Pool of Immature Langerhans Cells in the Epidermis

(2010) J. M. Kel et al.   JOURNAL OF IMMUNOLOGY

Herpes Simplex Virus Type 2 Enhances HIV-1 Susceptibility by Affecting Langerhans Cell Function

(2010) M. A. W. P. de Jong et al.   JOURNAL OF IMMUNOLOGY

Preferential Amplification of CD8 Effector-T Cells after Transcutaneous Application of an Inactivated Influenza Vaccine: A Randomized Phase I Trial

(2010) Behazine Combadière et al.   PLoS One

Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell

(2010) Laurent Chorro et al.   TRENDS IN IMMUNOLOGY

TLR2-activated human langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23

(2009) Ehsan Aliahmadi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

(2009) Akiharu Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

(2009) Laurent Chorro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells

(2009) B. Platzer et al.   JOURNAL OF IMMUNOLOGY

Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice

(2009) B. Jux et al.   JOURNAL OF IMMUNOLOGY

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production

(2009) H. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Langerhans cells and viral immunity

(2008) Anthony L. Cunningham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+ T cell stimulatory capacity

(2008) Matthias Peiser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions

(2008) Saskia J. A. M. Santegoets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

(2007) Lot de Witte et al.   TRENDS IN MOLECULAR MEDICINE