Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases

Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice

(2017) Chun-Pyo Hong et al.   GASTROENTEROLOGY

Commensal bacteria make GPCR ligands that mimic human signalling molecules

(2017) Louis J. Cohen et al.   NATURE

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

(2017) Jia Cao et al.   Nature Communications

The gut microbiota: a key regulator of metabolic diseases

(2016) Jin-Young Yang et al.   BMB Reports

GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states

(2016) Anna Veprik et al.   FASEB JOURNAL

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

(2016) Thibaut Duparc et al.   GUT

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Gut microbiota-associated bile acid deconjugation accelerates hepatic steatosis in ob/ob mice

(2016) M.-Y. Park et al.   JOURNAL OF APPLIED MICROBIOLOGY

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

(2016) Renee L. Greer et al.   Nature Communications

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia

(2016) Céline Pomié et al.   Molecular Metabolism

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

(2015) Vishal Singh et al.   Cell Metabolism

GPR43 Potentiates β-Cell Function in Obesity

(2015) Joanne C. McNelis et al.   DIABETES

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

(2015) E. Denou et al.   EMBO Molecular Medicine

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

(2015) Shuhong Guo et al.   JOURNAL OF IMMUNOLOGY

G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

(2015) Kurt Ritter et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Gut Microbiota and Metabolic Disorders

(2015) Kyu Yeon Hur et al.   Diabetes & Metabolism Journal

Bifidobacterium pseudocatenulatum CECT 7765 Reduces Obesity-Associated Inflammation by Restoring the Lymphocyte-Macrophage Balance and Gut Microbiota Structure in High-Fat Diet-Fed Mice

(2015) Angela Moya-Pérez et al.   PLoS One

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice

(2014) Benoit Chassaing et al.   GASTROENTEROLOGY

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Understanding the role of gut microbiome in metabolic disease risk

(2014) Yolanda Sanz et al.   PEDIATRIC RESEARCH

Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies

(2014) Derek J. Nunez et al.   PLoS One

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity

(2013) Marlene Remely et al.   GENE

Western diet induces dysbiosis with increasedE coliin CEABAC10 mice,alters host barrier function favouring AIEC colonisation

(2013) Margarita Martinez-Medina et al.   GUT

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet

(2013) Giuseppina Mattace Raso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism

(2013) Elodie Luche et al.   Molecular Metabolism

Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes

(2012) L. B. Katz et al.   DIABETES OBESITY & METABOLISM

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus

(2011) Scott V. Monte et al.   SURGERY

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA