Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies
Authors
Keywords
-
Journal
PLoS One
Volume 9, Issue 4, Pages e92494
Publisher
Public Library of Science (PLoS)
Online
2014-04-04
DOI
10.1371/journal.pone.0092494
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Towards improved receptor targeting: anterograde transport, internalization and postendocytic trafficking of neuropeptide Y receptors
- (2013) Stefanie Babilon et al. BIOLOGICAL CHEMISTRY
- Enteroendocrine cell types revisited
- (2013) Maja S Engelstoft et al. CURRENT OPINION IN PHARMACOLOGY
- Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes
- (2012) L. B. Katz et al. DIABETES OBESITY & METABOLISM
- Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with Type 2 diabetes mellitus
- (2012) S. K. Thondam et al. DIABETIC MEDICINE
- The therapeutic potential of GPR119 agonists for type 2 diabetes
- (2012) Takahide Ohishi et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
- (2012) Shinji Odori et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Lower Ghrelin Levels and Exaggerated Postprandial Peptide-YY, Glucagon-Like Peptide-1, and Insulin Responses, After Gastric Fundus Resection, in Patients Undergoing Roux-en-Y Gastric Bypass: A Randomized Clinical Trial
- (2012) Aikaterini Chronaiou et al. OBESITY SURGERY
- Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: fromin vitrodata to clinical study design
- (2012) Joseph W. Polli et al. XENOBIOTICA
- Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of JNJ-38431055, a Novel GPR119 Receptor Agonist and Potential Antidiabetes Agent, in Healthy Male Subjects
- (2011) L B Katz et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Mechanisms Underlying Metformin-Induced Secretion of Glucagon-Like Peptide-1 from the Intestinal L Cell
- (2011) Andrew J. Mulherin et al. ENDOCRINOLOGY
- Novel Biological Action of the Dipeptidylpeptidase-IV Inhibitor, Sitagliptin, as a Glucagon-Like Peptide-1 Secretagogue
- (2011) Ganesh V. Sangle et al. ENDOCRINOLOGY
- Effects of a Single Dose of Exenatide on Appetite, Gut Hormones, and Glucose Homeostasis in Adults with Prader-Willi Syndrome
- (2011) Lisa Sze et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Dipeptidyl Peptidase-4 Inhibitors Administered in Combination With Metformin Result in an Additive Increase in the Plasma Concentration of Active GLP-1
- (2010) E M Migoya et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Changes in Gastrointestinal Hormones and Leptin after Roux-en-Y Gastric Bypass Procedure: A Review
- (2010) Lauren M. Beckman et al. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
- Emerging therapies in the treatment of ‘diabesity’: beyond GLP-1
- (2010) George Tharakan et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Unraveling the Science of Incretin Biology
- (2009) Michael A. Nauck AMERICAN JOURNAL OF MEDICINE
- Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
- (2009) K. Aaboe et al. DIABETES OBESITY & METABOLISM
- Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes
- (2009) J. Cuthbertson et al. DIABETIC MEDICINE
- GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis
- (2009) Hong Lan et al. JOURNAL OF ENDOCRINOLOGY
- A Gut Feeling for Obesity: 7TM Sensors on Enteroendocrine Cells
- (2008) Maja S. Engelstoft et al. Cell Metabolism
- The role of peptide YY in appetite regulation and obesity
- (2008) Efthimia Karra et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview
- (2008) Sonia Correia et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation