Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection

Cellular and molecular regulation of innate inflammatory responses

(2016) Juan Liu et al.   Cellular & Molecular Immunology

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

(2016) Jie Li et al.   Cellular & Molecular Immunology

Regulation of inflammasomes by ubiquitination

(2016) Joseph S Bednash et al.   Cellular & Molecular Immunology

Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

(2016) Yajuan Li et al.   Cellular & Molecular Immunology

Bioinformatics analysis of organizational and expressional characterizations of the IFNs, IRFs and CRFBs in grass carp Ctenopharyngodon idella

(2016) Zhiwei Liao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Negative regulation of the antiviral response by grouper LGP2 against fish viruses

(2016) Yepin Yu et al.   FISH & SHELLFISH IMMUNOLOGY

Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew

(2016) Ling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells

(2015) Xiaohui Chen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Functions of MDA5 and its domains in response to GCRV or bacterial PAMPs

(2015) Tianle Gu et al.   FISH & SHELLFISH IMMUNOLOGY

Chicken STING Mediates Activation of the IFN Gene Independently of the RIG-I Gene

(2015) Yuqiang Cheng et al.   JOURNAL OF IMMUNOLOGY

The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation

(2015) Yaping Wang et al.   NATURE GENETICS

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

(2015) Youliang Rao et al.   Journal of Immunology Research

Dynamic localization and the associated translocation mechanism of HMGBs in response to GCRV challenge in CIK cells

(2014) Youliang Rao et al.   Cellular & Molecular Immunology

Testicular defense systems: immune privilege and innate immunity

(2014) Shutao Zhao et al.   Cellular & Molecular Immunology

Identification, characterization and immunological response analysis of stimulator of interferon gene (STING) from grass carp Ctenopharyngodon idella

(2014) Xiaoli Feng et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

MDA5 and LGP2: Accomplices and Antagonists of Antiviral Signal Transduction

(2014) K. R. Rodriguez et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

The Laboratory of Genetics and Physiology 2: Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor

(2014) Zixiang Zhu et al.   Biomed Research International

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

Characterizations of two grass carp Ctenopharyngodon idella HMGB2 genes and potential roles in innate immunity

(2013) Youliang Rao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant

(2013) Peng Fei Zou et al.   IMMUNOLOGY

The Antiviral Innate Immune Response in Fish: Evolution and Conservation of the IFN System

(2013) Christelle Langevin et al.   JOURNAL OF MOLECULAR BIOLOGY

Highlights of the advances in basic immunology in 2011

(2012) Juan Liu et al.   Cellular & Molecular Immunology

Molecular regulation of interferon antiviral response in fish

(2012) Yi-Bing Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Genomic sequence comparison, promoter activity, SNP detection of RIG-I gene and association with resistance/susceptibility to grass carp reovirus in grass carp (Ctenopharyngodon idella)

(2012) Quanyuan Wan et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2)

(2012) Annie M. Bruns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic organization, promoter activity of grass carp MDA5 and the association of its polymorphisms with susceptibility/resistance to grass carp reovirus

(2012) Lan Wang et al.   MOLECULAR IMMUNOLOGY

Functional Characterizations of RIG-I to GCRV and Viral/Bacterial PAMPs in Grass Carp Ctenopharyngodon idella

(2012) Lijun Chen et al.   PLoS One

Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I

(2012) Stéphane Biacchesi et al.   PLoS One

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Regulation of RLR-mediated innate immune signaling – It is all about keeping the balance

(2011) Katharina Eisenächer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of a retinoic acid-inducible gene I from grass carp (Ctenopharyngodon idella) and expression analysis in vivo and in vitro

(2011) Chunrong Yang et al.   FISH & SHELLFISH IMMUNOLOGY

Evaluation of internal control genes for qRT-PCR normalization in tissues and cell culture for antiviral studies of grass carp (Ctenopharyngodon idella)

(2011) Jianguo Su et al.   FISH & SHELLFISH IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I

(2011) H. Oshiumi et al.   JOURNAL OF BIOCHEMISTRY

Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss)

(2011) M. Chang et al.   JOURNAL OF VIROLOGY

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Characterization and antiviral function of a cytosolic sensor gene, MDA5, in Japanese flounder, Paralichthys olivaceus

(2010) Maki Ohtani et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Molecular cloning and immune responsive expression of MDA5 gene, a pivotal member of the RLR gene family from grass carp Ctenopharyngodon idella

(2010) Jianguo Su et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and expression profiling analysis of grass carp Ctenopharyngodon idella LGP2 cDNA

(2010) Teng Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Evolutional Conservation of Molecular Structure and Antiviral Function of a Viral RNA Receptor, LGP2, in Japanese Flounder, Paralichthys olivaceus

(2010) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Characterization of Fish IRF3 as an IFN-Inducible Protein Reveals Evolving Regulation of IFN Response in Vertebrates

(2010) F. Sun et al.   JOURNAL OF IMMUNOLOGY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin and evolution of the RIG-I like RNA helicase gene family

(2009) Jun Zou et al.   BMC EVOLUTIONARY BIOLOGY

REUL Is a Novel E3 Ubiquitin Ligase and Stimulator of Retinoic-Acid-Inducible Gene-I

(2009) Dong Gao et al.   PLoS One

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY