The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

Pathogenic Role of Associated Adherent-Invasive Escherichia coli in Crohn's Disease

(2017) Giuseppe Mazzarella et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors

(2017) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

The Interaction ofPneumocystiswith the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection

(2017) Theodore J. Kottom et al.   JOURNAL OF IMMUNOLOGY

Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy

(2017) Atul Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia

(2017) Sreedevi Chinthamani et al.   PLoS One

Rational design of adjuvants targeting the C-type lectin Mincle

(2017) Alexiane Decout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

(2017) Alexey V. Kostarnoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

(2017) Masahiro Nagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Mincle in innate immune to fungal keratitis

(2017) Guiqiu Zhao et al.   Journal of Infection in Developing Countries

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling

(2017) Emmanuel C. Patin et al.   PLoS One

New clinical phenotypes of fungal infections in special hosts

(2016) B. Pilmis et al.   CLINICAL MICROBIOLOGY AND INFECTION

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

C-type lectins: their network and roles in pathogen recognition and immunity

(2016) Sabine Mayer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection

(2016) Salvador Iborra et al.   IMMUNITY

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

(2016) Emmanuel C Patin et al.   Innate Immunity

An atypical role for the myeloid receptor Mincle in central nervous system injury

(2016) Thiruma V Arumugam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mincle Signaling Promotes Con A Hepatitis

(2016) Stephanie H. Greco et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis

(2016) Hermann Giresse Tima et al.   Journal of Innate Immunity

Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation

(2016) Bernhard Kerscher et al.   MICROBES AND INFECTION

Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle

(2016) Phillip L. van der Peet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cord factor as an invisibility cloak? A hypothesis for asymptomatic TB persistence

(2016) Robert L. Hunter et al.   TUBERCULOSIS

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease associated with Mycobacterium paratuberculosis

(2016) Karel P. Alcedo et al.   Gut Pathogens

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

(2016) Susanne Roth et al.   Cell Reports

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia

(2016) Friederike Behler-Janbeck et al.   PLoS Pathogens

Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4

(2016) Thomas Hupfer et al.   Frontiers in Immunology

Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge

(2015) Bernhard Kerscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis

(2015) Natalia Castaño-Rodríguez et al.   GUT

Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses

(2015) Ryoko Kiyotake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB

(2015) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation

(2015) Yasunobu Miyake et al.   JOURNAL OF IMMUNOLOGY

Mouse Mincle: Characterization as a Model for Human Mincle and Evolutionary Implications

(2015) Neela Rambaruth et al.   MOLECULES

Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle

(2015) Siddappa N. Byrareddy et al.   PLoS One

Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy

(2015) Savita Devi et al.   Scientific Reports

Aggregatibacter actinomycetemcomitans induces Th17 cells in atherosclerotic lesions

(2015) Ru Jia et al.   Pathogens and Disease

HIF1A regulates xenophagic degradation of adherent and invasiveEscherichia coli(AIEC)

(2014) Sanda Mimouna et al.   Autophagy

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

(2014) Brigitte A. Wevers et al.   Cell Host & Microbe

Listeria monocytogenes infection in inflammatory bowel disease patients

(2014) José Miranda-Bautista et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

(2014) Xue-Qiang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential stimulation of peripheral blood mononuclear cells in Crohn's disease by fungal glycans

(2014) Liran Baram et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBPβ and HIF1α

(2014) Hanne Schoenen et al.   JOURNAL OF IMMUNOLOGY

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Higher Activity of the Inducible Nitric Oxide Synthase Contributes to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S Dhillon et al.   Clinical and Translational Gastroenterology

Rates of Pneumococcal Disease in Adults With Chronic Medical Conditions

(2014) Kimberly M. Shea et al.   Open Forum Infectious Diseases

Danger-Associated Molecular Patterns and Inflammatory Bowel Disease: Is There a Connection?

(2013) Christoph Mueller   DIGESTIVE DISEASES

Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice

(2013) Harry Sokol et al.   GASTROENTEROLOGY

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

(2013) Yasunobu Miyake et al.   IMMUNITY

Increased Risk of Pneumocystis Jiroveci Pneumonia Among Patients with Inflammatory Bowel Disease

(2013) Millie D. Long et al.   INFLAMMATORY BOWEL DISEASES

Protective Role of Mincle in Bacterial Pneumonia by Regulation of Neutrophil Mediated Phagocytosis and Extracellular Trap Formation

(2013) A. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

(2013) Christiane Desel et al.   PLoS One

Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis

(2013) J. S. Nijjar et al.   RHEUMATOLOGY

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

(2013) Yukiya Suzuki et al.   Scientific Reports

Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis

(2013) Roland Lang   Frontiers in Immunology

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome

(2012) Katrin Schweneker et al.   IMMUNOBIOLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression

(2010) C. Ribbing et al.   ALLERGY

Is there a role for Crohnʼs disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

(2010) Simone C. Wolfkamp et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays

(2009) Chandrassegar Saravanan et al.   GLYCOBIOLOGY

Pityrosporum folliculitis in a Crohnʼs disease patient receiving infliximab

(2009) Amana Nasir et al.   INFLAMMATORY BOWEL DISEASES

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen

(2009) Harumi Jyonouchi et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

(2009) Sho Yamasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

(2008) A. Bugarcic et al.   GLYCOBIOLOGY

Sensing necrosis with Mincle

(2008) Gordon D Brown   NATURE IMMUNOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY