Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function

PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells

(2017) L Sun et al.   LEUKEMIA

Liver X receptor activation promotes differentiation of regulatory T cells

(2017) Martin Herold et al.   PLoS One

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

(2017) Elisa Araldi et al.   Cell Reports

Cell membranes: A subjective perspective

(2016) Kai Simons   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order

(2016) Kandice R. Levental et al.   BIOPHYSICAL JOURNAL

Modulating Cholesterol Homeostasis to Build a Better T Cell

(2016) Yoko Kidani et al.   Cell Metabolism

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

(2016) Todd G. Kirchgessner et al.   Cell Metabolism

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

T-cell metabolism governing activation, proliferation and differentiation; a modular view

(2016) Sarah Dimeloe et al.   IMMUNOLOGY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

(2016) Feng Wang et al.   NATURE IMMUNOLOGY

A Bayesian cluster analysis method for single-molecule localization microscopy data

(2016) Juliette Griffié et al.   Nature Protocols

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

(2016) Sara Della Torre et al.   Cell Reports

Liver X receptors at the intersection of lipid metabolism and atherogenesis

(2015) Stephen D. Lee et al.   ATHEROSCLEROSIS

Manipulating membrane lipid profiles to restore T-cell function in autoimmunity

(2015) Kirsty E. Waddington et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Liver X receptors in immune cell function in humans: Figure 1

(2015) Kirsty E. Waddington et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

(2015) Marielle S. Köberlin et al.   CELL

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

(2015) Fabiola Bovenga et al.   Cell Metabolism

Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1

(2015) Vasiliki Pelekanou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The G-protein coupled estrogen receptor, GPER: The inside and inside-out story

(2015) H.M. Gaudet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Bayesian cluster identification in single-molecule localization microscopy data

(2015) Patrick Rubin-Delanchy et al.   NATURE METHODS

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

(2015) Ayaka Ito et al.   eLife

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

Gender differences in autoimmune disease

(2014) S.T. Ngo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message

(2014) C. Nazarov-Stoica et al.   JOURNAL OF IMMUNOLOGY

Modulation of autoimmune rheumatic diseases by oestrogen and progesterone

(2014) Grant C. Hughes et al.   Nature Reviews Rheumatology

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Targeting liver X receptors in inflammation

(2013) Knut R Steffensen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

(2013) Tomonori Ishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice

(2013) Astrid Kosters et al.   PLoS One

Mutation of the palmitoylation site of estrogen receptor   in vivo reveals tissue-specific roles for membrane versus nuclear actions

(2013) M. Adlanmerini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of ERα36 in membrane-associated signaling by estrogen

(2013) Reyhaan A. Chaudhri et al.   STEROIDS

The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization

(2013) C Wang et al.   Cell Death & Disease

Imaging lipid domains in cell membranes: the advent of super-resolution fluorescence microscopy

(2013) Dylan M. Owen et al.   Frontiers in Plant Science

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

(2013) Sumathi Sankaran-Walters et al.   Biology of Sex Differences

HDL and ApoA-I inhibit antigen presentation-mediated T cell activation by disrupting lipid rafts in antigen presenting cells

(2012) Shu-hui Wang et al.   ATHEROSCLEROSIS

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4 and CD8 T cells require different membrane gangliosides for activation

(2012) M. Nagafuku et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Lowering Glycosphingolipid Levels in CD4+T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th17Lineage

(2011) Yunxiang Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Human CD4+ T Cells Have Diverse Levels of Membrane Lipid Order That Correlate with Their Function

(2011) L. Miguel et al.   JOURNAL OF IMMUNOLOGY

Quantitative imaging of membrane lipid order in cells and organisms

(2011) Dylan M Owen et al.   Nature Protocols

The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes

(2011) Rosamaria Lappano et al.   PLoS One

Raft domains of variable properties and compositions in plasma membrane vesicles

(2011) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis

(2010) Jae-Ho Cho et al.   IMMUNITY

Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

(2010) Saravanan Kanakasabai et al.   IMMUNOLOGY

Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory Stimuli

(2010) D. Torocsik et al.   JOURNAL OF IMMUNOLOGY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Intracellular sterol dynamics

(2009) Bruno Mesmin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1

(2009) C. Wang et al.   JOURNAL OF IMMUNOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Plasma membrane estrogen receptors

(2009) Ellis R. Levin   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver X receptor modulators: Effects on lipid metabolism and potential use in the treatment of atherosclerosis

(2008) C. Fiévet et al.   BIOCHEMICAL PHARMACOLOGY

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse

(2008) John L. Svenson et al.   CLINICAL IMMUNOLOGY

PPARδ Is a Type 1 IFN Target Gene and Inhibits Apoptosis in T Cells

(2008) Nadya al Yacoub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ

(2008) Anna Foryst-Ludwig et al.   PLoS Genetics