Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8+ T Cell Responses

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

(2017) Thomas Kammertoens et al.   NATURE

Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery

(2015) Stefaan De Koker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses

(2015) Qin Zeng et al.   JOURNAL OF CONTROLLED RELEASE

Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory

(2015) Ce Wang et al.   JOURNAL OF CONTROLLED RELEASE

Al adjuvants can be tracked in viable cells by lumogallion staining

(2015) Irene Mile et al.   JOURNAL OF IMMUNOLOGICAL METHODS

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response

(2015) Xiaojun Xia et al.   Cell Reports

Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1

(2014) Zhaolu Xie et al.   BIOMATERIALS

Nano-chemotherapeutics: Maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers

(2014) Gemma M. Ryan et al.   JOURNAL OF CONTROLLED RELEASE

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

(2014) S. Hirosue et al.   JOURNAL OF IMMUNOLOGY

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

(2013) Zhenghong Xu et al.   JOURNAL OF CONTROLLED RELEASE

Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens

(2013) Nicholas O. Fischer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer

(2013) Jianfeng Han et al.   Small

Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

(2012) Stuart M. Levitz et al.   CELL

Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response

(2012) Randip Kaur et al.   JOURNAL OF CONTROLLED RELEASE

A Cell-Specific Poly(ethylene glycol) Derivative with a Wheat-like Structure for Efficient Gene Delivery

(2012) Hanmei Li et al.   MOLECULAR PHARMACEUTICS

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Innovative strategies for co-delivering antigens and CpG oligonucleotides

(2009) Yogita Krishnamachari et al.   ADVANCED DRUG DELIVERY REVIEWS

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

(2009) Stefaan De Koker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minireview: Nanoparticles and the Immune System

(2009) Banu S. Zolnik et al.   ENDOCRINOLOGY

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY