Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate

Three-Dimensional Directionality Is a Pivotal Structural Feature for the Bioactivity of Azabisphosphonate-Capped Poly(PhosphorHydrazone) Nanodrug Dendrimers

(2018) Myriam Hayder et al.   BIOMACROMOLECULES

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

(2018) Anjali Sharma et al.   JOURNAL OF CONTROLLED RELEASE

The ABP Dendrimer, a Drug-Candidate against Inflammatory Diseases That Triggers the Activation of Interleukin-10 Producing Immune Cells

(2018) Séverine Fruchon et al.   MOLECULES

In vitro genotoxicity testing–Can the performance be enhanced?

(2017) Raffaella Corvi et al.   FOOD AND CHEMICAL TOXICOLOGY

Pro-Inflammatory Versus Anti-Inflammatory Effects of Dendrimers: The Two Faces of Immuno-Modulatory Nanoparticles

(2017) Séverine Fruchon et al.   Nanomaterials

Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

(2016) Alan Enciso et al.   MOLECULES

Poly(phosphorhydrazone) dendrimers: yin and yang of monocyte activation for human NK cell amplification applied to immunotherapy against multiple myeloma

(2016) Mary Poupot et al.   Nanomedicine-Nanotechnology Biology and Medicine

Perspective: Dendrimer drugs for infection and inflammation

(2015) Sunil Shaunak   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorus-Based Dendrimer ABP Treats Neuroinflammation by Promoting IL-10-Producing CD4+ T Cells

(2015) Myriam Hayder et al.   BIOMACROMOLECULES

The dendrimer paradox – high medical expectations but poor clinical translation

(2015) Sonke Svenson   CHEMICAL SOCIETY REVIEWS

Interaction studies reveal specific recognition of an anti-inflammatory polyphosphorhydrazone dendrimer by human monocytes

(2015) Jérémy Ledall et al.   Nanoscale

The key role of the scaffold on the efficiency of dendrimer nanodrugs

(2015) Anne-Marie Caminade et al.   Nature Communications

Repeated intravenous injections in non-human primates demonstrate preclinical safety of an anti-inflammatory phosphorus-based dendrimer

(2014) Séverine Fruchon et al.   Nanotoxicology

Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent

(2014) Yannick Degboé et al.   ARTHRITIS RESEARCH & THERAPY

Charge affects the oral toxicity of poly(amidoamine) dendrimers

(2013) Giridhar Thiagarajan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

An Azabisphosphonate-Capped Poly(phosphorhydrazone) Dendrimer for the Treatment of Endotoxin-Induced Uveitis

(2013) Séverine Fruchon et al.   MOLECULES

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

Dendrimer toxicity: Let's meet the challenge

(2010) Keerti Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biological Assessment of Triazine Dendrimer: Toxicological Profiles, Solution Behavior, Biodistribution, Drug Release and Efficacy in a PEGylated, Paclitaxel Construct

(2010) Su-Tang Lo et al.   MOLECULAR PHARMACEUTICS

Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework

(2009) Antoine Soubret et al.   Drug Metabolism and Pharmacokinetics

Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy

(2009) Damien Portevin et al.   Journal of Translational Medicine

Evaluation of nanoparticle immunotoxicity

(2009) Marina A. Dobrovolskaia et al.   Nature Nanotechnology

Tailored Control and Optimisation of the Number of Phosphonic Acid Termini on Phosphorus-Containing Dendrimers for the Ex-Vivo Activation of Human Monocytes

(2008) Olivier Rolland et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-inflammatory and immunosuppressive activation of human monocytes by a bioactive dendrimer

(2008) Séverine Fruchon et al.   JOURNAL OF LEUKOCYTE BIOLOGY