Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target

Bcl-2 inhibitors reduce steroid-insensitive airway inflammation

(2017) Bao-ping Tian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophil-Derived Exosomes: A New Mechanism Contributing to Airway Smooth Muscle Remodeling

(2016) Amandine Vargas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma

(2016) D. L. Pham et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Recombinant human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model

(2016) Aline Andrea da Cunha et al.   EXPERIMENTAL LUNG RESEARCH

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects

(2016) Candice M. Todd et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

(2016) Duy Le Pham et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial

(2016) Paul M O'Byrne et al.   Lancet Respiratory Medicine

Recapitulation of in vivo-like neutrophil transendothelial migration using a microfluidic platform

(2015) Xiaojie Wu et al.   ANALYST

Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target

(2015) G.-Y. Ban et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Airway dysbiosis:Haemophilus influenzaeandTropherymain poorly controlled asthma

(2015) Jodie L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial

(2015) J. Daan de Boer et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease-relevant neutrophil phenotype?

(2015) P. L. B. Bruijnzeel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

(2015) L Dejager et al.   Mucosal Immunology

A Microfluidic Platform for Evaluating Neutrophil Chemotaxis Induced by Sputum from COPD Patients

(2015) Jiandong Wu et al.   PLoS One

Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma

(2015) Francesca S.M. Tang et al.   RESPIROLOGY

Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

(2015) Ama-Tawiah Essilfie et al.   THORAX

The changing face of asthma and its relation with microbes

(2015) Chris S. Earl et al.   TRENDS IN MICROBIOLOGY

Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1

(2015) Koa Hosoki et al.   PLoS One

Occupational exposures, smoking and airway inflammation in refractory asthma

(2015) Jodie L Simpson et al.   BMC Pulmonary Medicine

Neutrophils from allergic asthmatic patients produce and release metalloproteinase-9 upon direct exposure to allergens

(2014) I. Ventura et al.   ALLERGY

Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils

(2014) Jean-Christophe Simard et al.   FEBS LETTERS

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

No Direct Association Between Asthma and the Microbiome Based on Currently Available Techniques

(2014) Josef Yayan   MEDICINE

The complex relationship between inflammation and lung function in severe asthma

(2014) M L Manni et al.   Mucosal Immunology

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

(2014) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

(2014) A. J. Theron et al.   Journal of Immunology Research

Anti-TNF inhibits the Airways neutrophilic inflammation induced by inhaled endotoxin in human

(2014) Olivier Michel et al.   BMC Pharmacology & Toxicology

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma

(2013) Tae-Hyeong Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The study of the ratio and distribution of Th17 cells and Tc17 cells in asthmatic patients and the mouse model

(2013) Kaiyan Li   ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY

A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition

(2013) Y Kobayashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Th17-mediated inflammation in asthma

(2013) Dawn C Newcomb et al.   CURRENT OPINION IN IMMUNOLOGY

Effect of Formoterol on Eosinophil Trans-Basement Membrane Migration Induced by Interleukin-8-Stimulated Neutrophils

(2013) Akiko Kawashima et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway

(2013) Irina N. Gavrilovskaya et al.   JOURNAL OF VIROLOGY

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

(2013) Dominique Baeten et al.   LANCET

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma

(2013) Mohib Uddin et al.   PLoS One

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

(2013) Hikari Koga et al.   RESPIRATORY RESEARCH

Interleukin-6 and statin therapy: potential role in the management of COPD

(2013) Robert P Young et al.   RESPIRATORY RESEARCH

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma

(2012) P. Torregrosa Paredes et al.   ALLERGY

Role of YKL-40 in Bronchial Smooth Muscle Remodeling in Asthma

(2012) Imane Bara et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

(2012) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

β2 long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD

(2012) Mirella Profita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Statins enhance the effects of corticosteroids on the balance between regulatory T cells and Th17 cells

(2012) K. Maneechotesuwan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Autophagy and role in asthma

(2012) Soma S.S.K. Jyothula et al.   CURRENT OPINION IN PULMONARY MEDICINE

Neutrophilic Inflammation in Severe Asthma

(2012) Kazuyuki Nakagome et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

(2012) Mercedes Rincon et al.   International Journal of Biological Sciences

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

(2012) Magdalena Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

YKL-40 Induces IL-8 Expression from Bronchial Epithelium via MAPK (JNK and ERK) and NF- B Pathways, Causing Bronchial Smooth Muscle Proliferation and Migration

(2012) H. Tang et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway

(2012) Junko Yano et al.   PLoS One

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

(2011) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

(2011) Markus F. Neurath et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Different inflammatory phenotypes in adults and children with acute asthma

(2011) F. Wang et al.   EUROPEAN RESPIRATORY JOURNAL

The sentinel role of the airway epithelium in asthma pathogenesis

(2011) Stephen T. Holgate   IMMUNOLOGICAL REVIEWS

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

(2011) Ryszard Dworski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells

(2011) Dao-Feng Yang et al.   MOLECULAR IMMUNOLOGY

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of neutrophils in persistent airway obstruction due to refractory asthma

(2011) JAE-SUNG CHOI et al.   RESPIROLOGY

Systemic upregulation of neutrophil  -defensins and serine proteases in neutrophilic asthma

(2011) K. J. Baines et al.   THORAX

IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo

(2010) Anouk Lavoie-Lamoureux et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

(2010) Camille Doe et al.   CHEST

Regulation of the autophagic machinery in human neutrophils

(2010) Ioannis Mitroulis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E

(2010) H. Tang et al.   EUROPEAN RESPIRATORY JOURNAL

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

A novel subset of CD4+TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

(2010) Yui-Hsi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 Promotes p38 MAPK-Dependent Endothelial Activation Enhancing Neutrophil Recruitment to Sites of Inflammation

(2010) L. Roussel et al.   JOURNAL OF IMMUNOLOGY

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Increased serum IL-17 is an independent risk factor for severe asthma

(2010) Ioana Agache et al.   RESPIRATORY MEDICINE

Sputum IL-6 concentrations in severe asthma and its relationship with FEV1

(2010) J. B. Morjaria et al.   THORAX

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression of the high affinity IgE receptor by neutrophils of individuals with allergic asthma is both minimal and insensitive to regulation by serum IgE

(2009) Juanita Mora et al.   CLINICAL IMMUNOLOGY

ONCOSTATIN M (OSM) IS INCREASED IN ASTHMA WITH INCOMPLETELY REVERSIBLE AIRFLOW OBSTRUCTION

(2009) Jodie L. Simpson et al.   EXPERIMENTAL LUNG RESEARCH

Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activationin Vivoand Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

(2009) Veronica C. Ardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

(2009) Chun Geun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early activation of coagulation after allergen challenge in patients with allergic asthma

(2009) M. SCHOUTEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effects of steroid therapy on inflammatory cell subtypes in asthma

(2009) D. C. Cowan et al.   THORAX

Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

(2008) Kazuhiro Ito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3

(2008) B. J. van Raam et al.   BLOOD

Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions

(2008) H.F. Galley et al.   BRITISH JOURNAL OF ANAESTHESIA

Advances in Neutrophil Biology

(2008) Andrew S. Cowburn et al.   CHEST

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

CXCR2 antagonists for the treatment of pulmonary disease

(2008) R.W. Chapman et al.   PHARMACOLOGY & THERAPEUTICS

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Friendly fire against neutrophils: Proteolytic enzymes confuse the recognition of apoptotic cells by macrophages

(2007) Krzysztof Guzik et al.   BIOCHIMIE

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor

(2007) M. Uddin et al.   EUROPEAN RESPIRATORY JOURNAL