Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice

(2017) Kai Li et al.   Scientific Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses

(2016) Gagan Bajwa et al.   JOURNAL OF IMMUNOLOGY

Evaluation of the PPAR-γ Agonist Pioglitazone in Mild Asthma: A Double-Blind Randomized Controlled Trial

(2016) J. R. Anderson et al.   PLoS One

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence

(2016) Giselle M. Boukhaled et al.   Cell Reports

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development

(2015) Samuel Philip Nobs et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells

(2015) Frano Malinarich et al.   JOURNAL OF IMMUNOLOGY

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

(2015) Andreas Schlitzer et al.   NATURE IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

(2015) Amarjit Mishra et al.   Nature Communications

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Inhibition Extends Cellular Lifespan in Dendritic Cells by Preserving Mitochondrial Function

(2014) Eyal Amiel et al.   JOURNAL OF IMMUNOLOGY

L-Myc expression by dendritic cells is required for optimal T-cell priming

(2014) Wumesh KC et al.   NATURE

Glycolytic reprogramming by TLRs in dendritic cells

(2014) Luke A J O'Neill   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

NAD+ protects against EAE by regulating CD4+ T-cell differentiation

(2014) Stefan G. Tullius et al.   Nature Communications

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells

(2013) Regina Wobben et al.   BIOLOGICAL CHEMISTRY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

From bedside to bench to clinic trials: identifying new treatments for severe asthma

(2013) A. Mishra et al.   Disease Models & Mechanisms

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells

(2013) Leonie Hussaarts et al.   IMMUNOLOGY AND CELL BIOLOGY

Severe adult-onset asthma: A distinct phenotype

(2013) Marijke Amelink et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histone Deacetylase Sirtuin 1 Deacetylates IRF1 Protein and Programs Dendritic Cells to Control Th17 Protein Differentiation during Autoimmune Inflammation

(2013) Heeyoung Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Fatty-Acid Synthesis in Dendritic Cell Generation and Function

(2013) A. Rehman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase in Lung CD103+ but Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T Cells and Promote Airway Tolerance

(2013) A. Khare et al.   JOURNAL OF IMMUNOLOGY

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Metformin Attenuates the Exacerbation of the Allergic Eosinophilic Inflammation in High Fat-Diet-Induced Obesity in Mice

(2013) Marina Ciarallo Calixto et al.   PLoS One

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

(2013) Jesse W. Williams et al.   Nature Communications

Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase

(2012) Chan Sun Park et al.   BIOCHEMICAL PHARMACOLOGY

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Dendritic Cell Populations With Different Concentrations of Lipid Regulate Tolerance and Immunity in Mouse and Human Liver

(2012) Junaid Ibrahim et al.   GASTROENTEROLOGY

An active mitochondrial biogenesis occurs during dendritic cell differentiation

(2012) Patrizia Zaccagnino et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells

(2012) Han Xian Aw Yeang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice

(2012) E. Amiel et al.   JOURNAL OF IMMUNOLOGY

The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells

(2012) Maria Maryanovich et al.   NATURE CELL BIOLOGY

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Paradoxical Effects of Rapamycin on Experimental House Dust Mite-Induced Asthma

(2012) Karin Fredriksson et al.   PLoS One

Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma

(2012) TOMOMI ICHIKAWA et al.   RESPIROLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-  Activity in Dendritic Cells

(2011) A. Legutko et al.   JOURNAL OF IMMUNOLOGY

Rapamycin Attenuates Airway Hyperreactivity, Goblet Cells, and IgE in Experimental Allergic Asthma

(2011) E. M. Mushaben et al.   JOURNAL OF IMMUNOLOGY

The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes

(2011) Lucia Lisi et al.   Journal of Neuroinflammation

Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens

(2011) H Nakano et al.   Mucosal Immunology

Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses

(2011) M Semmrich et al.   Mucosal Immunology

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS

(2010) H. R. Turnquist et al.   BLOOD

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells

(2010) Shin-Ichi Inoue et al.   FEBS LETTERS

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

(2010) Taheri Sathaliyawala et al.   IMMUNITY

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

(2010) M. Haidinger et al.   JOURNAL OF IMMUNOLOGY

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

(2010) Yehudit Zaltsman et al.   NATURE CELL BIOLOGY

Effects of TLR Agonists on the Hypoxia-Regulated Transcription Factor HIF-1α and Dendritic Cell Maturation under Normoxic Conditions

(2010) Rolf Spirig et al.   PLoS One

Nuclear Erythroid 2 p45-Related Factor 2 Inhibits the Maturation of Murine Dendritic Cells by Ragweed Extract

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rapamycin Down-Regulates Inducible Nitric Oxide Synthase by Inducing Proteasomal Degradation

(2009) Hye Kyoung Jin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Bronchodilatory Effect of the PPAR-γ Agonist Rosiglitazone in Smokers With Asthma

(2009) M Spears et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Biology of Lung Dendritic Cells at the Origin of Asthma

(2009) Bart N. Lambrecht et al.   IMMUNITY

Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation

(2009) Urban Švajger et al.   IMMUNOLOGY

An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation

(2009) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: A randomised controlled trial

(2009) Duncan B. Richards et al.   RESPIRATORY MEDICINE

In Vivo Analysis of Dendritic Cell Development and Homeostasis

(2009) K. Liu et al.   SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE