NAD+ protects against EAE by regulating CD4+ T-cell differentiation

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers

(2013) Myung Jin Son et al.   STEM CELLS

β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury

(2012) Nagavedi Siddaramappa Umapathy et al.   EXPERIMENTAL LUNG RESEARCH

NAD+Levels Control Ca2+Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes

(2012) Mirko Magnone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

(2012) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome

(2011) Laura Passerini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

(2011) Yasutaka Motomura et al.   NATURE IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

(2010) Sandra Hubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel subset of CD4+TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

(2010) Yui-Hsi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The complement receptor CD46 tips the scales in TH1 self-control

(2010) Christian M Karsten et al.   NATURE IMMUNOLOGY

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

(2010) John Cardone et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Regulation and Function of Proinflammatory TH17 Cells

(2009) Gustavo J. Martinez et al.   Annals of the New York Academy of Sciences

The Importance of NAD in Multiple Sclerosis

(2009) W. Penberthy et al.   CURRENT PHARMACEUTICAL DESIGN

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

(2009) Santina Bruzzone et al.   PLoS One

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Th1 and Th17 cells in organ-specific autoimmunity

(2008) Valérie Dardalhon et al.   JOURNAL OF AUTOIMMUNITY

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL