Biopharmaceutical drug targeting to the brain

Alzheimer's disease drug development and the problem of the blood-brain barrier

(2009) William M. Pardridge   Alzheimers & Dementia

Comparison of Blood-Brain Barrier Transport of Glial-Derived Neurotrophic Factor (GDNF) and an IgG-GDNF Fusion Protein in the Rhesus Monkey

(2009) R. J. Boado et al.   DRUG METABOLISM AND DISPOSITION

AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

(2009) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Tumor Necrosis Factor Receptor-IgG Fusion Protein for Targeted Drug Delivery across the Human Blood−Brain Barrier

(2009) Eric Ka-Wai Hui et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery

(2009) William M. Pardridge et al.   PHARMACEUTICAL RESEARCH

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Genetic Engineering, Expression, and Activity of a Chimeric Monoclonal Antibody−Avidin Fusion Protein for Receptor-Mediated Delivery of Biotinylated Drugs in Humans

(2008) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Re-Engineering Biopharmaceuticals for Delivery to Brain with Molecular Trojan Horses

(2008) William M. Pardridge   BIOCONJUGATE CHEMISTRY

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

(2008) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Characterization of the Pharmacokinetics of Human Recombinant Erythropoietin in Blood and Brain When Administered Immediately after Lateral Fluid Percussion Brain Injury and Its Pharmacodynamic Effects on IL-1β and MIP-2 in Rats

(2008) Thomas Lieutaud et al.   JOURNAL OF NEUROTRAUMA

IgG-Paraoxonase-1 Fusion Protein for Targeted Drug Delivery across the Human Blood−Brain Barrier

(2008) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Targeting of the CNS in MPS-IH Using a Nonviral Transferrin-α-l-iduronidase Fusion Gene Product

(2008) Mark J Osborn et al.   MOLECULAR THERAPY

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

(2008) Babak Nazer et al.   NEUROBIOLOGY OF DISEASE

GDNF fusion protein for targeted-drug delivery across the human blood–brain barrier

(2007) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING