Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

(2016) Yulia Pustovalova et al.   BIOCHEMISTRY

R.I.P. to the PIP: PCNA-binding motif no longer considered specific

(2016) Elizabeth M. Boehm et al.   BIOESSAYS

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

(2016) Kaori Kobayashi et al.   CELL CYCLE

Insights into the complex levels of regulation imposed on Escherichia coli DNA polymerase V

(2016) Myron F. Goodman et al.   DNA REPAIR

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

(2016) Elizabeth M. Boehm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

(2016) Dmitry M. Korzhnev et al.   JOURNAL OF MEDICINAL CHEMISTRY

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

POLD3 Is Haploinsufficient for DNA Replication in Mice

(2016) Matilde Murga et al.   MOLECULAR CELL

Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1

(2016) Xin Xu et al.   NUCLEIC ACIDS RESEARCH

PCNA tool belts and polymerase bridges form during translesion synthesis

(2016) Elizabeth M. Boehm et al.   NUCLEIC ACIDS RESEARCH

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ

(2016) Vikash Jha et al.   NUCLEIC ACIDS RESEARCH

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

(2016) Mark Hedglin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

(2016) Mark Hedglin et al.   eLife

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

(2016) Olga Yurieva et al.   Nucleus

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

(2016) Olga Yurieva et al.   Nucleus

Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress

(2016) Néstor García-Rodríguez et al.   Frontiers in Genetics

Contributions of the specialised DNA polymerases to replication of structured DNA

(2015) Caroline M. Wickramasinghe et al.   DNA REPAIR

The steady-state level and stability of TLS polymerase eta are cell cycle dependent in the yeast S. cerevisiae

(2015) Michal Plachta et al.   DNA REPAIR

Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins

(2015) Justyna McIntyre et al.   DNA REPAIR

Eukaryotic DNA polymerase ζ

(2015) Alena V. Makarova et al.   DNA REPAIR

Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease

(2015) Jacob G. Jansen et al.   DNA REPAIR

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol

(2015) María I. Martínez-Jiménez et al.   DNA REPAIR

Base damage, local sequence context andTP53mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

(2015) Georgina E. Menzies et al.   NUCLEIC ACIDS RESEARCH

FF483–484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance

(2015) Nadège Baldeck et al.   NUCLEIC ACIDS RESEARCH

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

(2015) Zbigniew Darzynkiewicz et al.   Oncotarget

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA

(2015) Wilson C. Y. Lau et al.   Scientific Reports

The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage

(2015) Masashi Uchiyama et al.   PLoS One

Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine

(2014) Maroof K. Zafar et al.   BIOCHEMISTRY

Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells

(2014) Hong Zhao et al.   CELL CYCLE

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase  

(2014) H. A. Wallace et al.   DEVELOPMENT

PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage

(2014) Nikolay Tsanov et al.   NUCLEIC ACIDS RESEARCH

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory Role of Ubiquitin in Eukaryotic DNA Translesion Synthesis

(2013) Kun Yang et al.   BIOCHEMISTRY

The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

(2013) Marietta Y.W.T. Lee et al.   CELL CYCLE

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ

(2013) Lynne M. Dieckman et al.   DNA REPAIR

XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair

(2013) Scott A. Gabel et al.   DNA REPAIR

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

(2013) Li Wan et al.   EMBO REPORTS

Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis

(2013) Parvathi Chary et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

NMR Mapping of PCNA Interaction with Translesion Synthesis DNA Polymerase Rev1 Mediated by Rev1-BRCT Domain

(2013) Yulia Pustovalova et al.   JOURNAL OF MOLECULAR BIOLOGY

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Regulation of PCNA–protein interactions for genome stability

(2013) Niels Mailand et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

Translesion DNA Polymerases

(2013) M. F. Goodman et al.   Cold Spring Harbor Perspectives in Biology

The Architecture of Yeast DNA Polymerase ζ

(2013) Yacob Gómez-Llorente et al.   Cell Reports

NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase η

(2012) Alexandra Pozhidaeva et al.   BIOCHEMISTRY

Regulation of the specialized DNA polymerase eta: Revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs

(2012) Emmanuelle Despras et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA polymerase delta in dna replication and genome maintenance

(2012) Marc J. Prindle et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase η in Response to CarcinogenN-Methyl-N′-nitro-N-nitrosoguanidine

(2012) Hongyan Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Vital Role of Polymerase ζ and REV1 in Mutagenic, but Not Correct, DNA Synthesis across Benzo[a]pyrene-dG and Recruitment of Polymerase ζ by REV1 to Replication-stalled Site

(2012) Keiji Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

(2012) Sotaro Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

(2012) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation

(2012) Y. Shiomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

(2012) Nami Haruta et al.   NUCLEIC ACIDS RESEARCH

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis

(2012) Alena V. Makarova et al.   NUCLEIC ACIDS RESEARCH

Pol31 and Pol32 subunits of yeast DNA polymerase   are also essential subunits of DNA polymerase  

(2012) R. E. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the assembly of human translesion polymerase complexes

(2012) Wei Xie et al.   Protein & Cell

Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis

(2011) Zvi Livneh et al.   CELL CYCLE

DNA replication and repair bypass machines

(2011) Ulrich Hübscher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1

(2011) Mary Ellen Wiltrout et al.   DNA REPAIR

DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation

(2011) Yong-Sam Jung et al.   DNA REPAIR

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

(2011) Neeru M. Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

(2011) Thomas Göhler et al.   JOURNAL OF CELL BIOLOGY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

(2011) Y.-S. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites

(2011) Parker L. Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

(2011) Ayal Hendel et al.   PLoS Genetics

The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis

(2010) Xiao Meng et al.   BIOCHEMISTRY

Error-free replicative bypass of (6-4) photoproducts by DNA polymerase   in mouse and human cells

(2010) J.-H. Yoon et al.   GENES & DEVELOPMENT

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange

(2010) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Variations on a theme: Eukaryotic Y-family DNA polymerases

(2009) M. Todd Washington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Coordinating DNA polymerase traffic during high and low fidelity synthesis

(2009) Mark D. Sutton   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Interaction with DNA polymerase η is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells

(2009) Jun-ichi Akagi et al.   DNA REPAIR

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

(2009) Sigal Shachar et al.   EMBO JOURNAL

Identification of a novel REV1-interacting motif necessary for DNA polymerase κ function

(2009) Eiji Ohashi et al.   GENES TO CELLS

Proliferating Cell Nuclear Antigen Uses Two Distinct Modes to Move along DNA

(2009) Anna B. Kochaniak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

(2009) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation

(2009) Y.-S. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Influence of local sequence context on damaged base conformation in human DNA polymerase ι: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion

(2009) Kerry Donny-Clark et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin-binding motif of human DNA polymerase η is required for correct localization: Fig. 1.

(2009) Simone Sabbioneda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases

(2008) Simone Sabbioneda et al.   MOLECULAR BIOLOGY OF THE CELL

Regulated Proteolysis of DNA Polymerase η during the DNA-Damage Response in C. elegans

(2008) Seung-Hwan Kim et al.   MOLECULAR CELL

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

(2008) Dávid Szüts et al.   NUCLEIC ACIDS RESEARCH

Regulation of polymerase exchange between Pol  and Pol  by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

(2008) Z. Zhuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase   in translesion DNA synthesis

(2008) N. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA