Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome

Timeless protection of telomeres

(2016) Mariana C. Gadaleta et al.   CURRENT GENETICS

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structuresin vitroand are unwound by the Pfh1 DNA helicase

(2016) Marcus Wallgren et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome

(2016) Andrzej S Kudlicki   PLoS One

Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest

(2016) Deepak Bastia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres

(2016) Mariana C. Gadaleta et al.   PLoS Genetics

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

(2016) Karin R. McDonald et al.   PLoS Genetics

Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase

(2015) Xi-Miao Hou et al.   BIOCHEMICAL JOURNAL

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanism of regulation of ‘chromosome kissing’ induced by Fob1 and its physiological significance

(2015) Malay Choudhury et al.   GENES & DEVELOPMENT

G-quadruplexes Significantly Stimulate Pif1 Helicase-catalyzed Duplex DNA Unwinding

(2015) Xiao-Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity

(2015) Yufuko Akamatsu et al.   MOLECULAR AND CELLULAR BIOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers

(2015) Juergen Zech et al.   PLoS One

An RNA polymerase III subunit determines sites of retrotransposon integration

(2015) A. Bridier-Nahmias et al.   SCIENCE

Arrested replication forks guide retrotransposon integration

(2015) J. Z. Jacobs et al.   SCIENCE

High-Resolution Profiling of Drosophila Replication Start Sites Reveals a DNA Shape and Chromatin Signature of Metazoan Origins

(2015) Federico Comoglio et al.   Cell Reports

Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro

(2015) Jonathan D. Williams et al.   Frontiers in Genetics

Transcription-Associated Mutagenesis

(2014) Sue Jinks-Robertson et al.   Annual Review of Genetics

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage

(2014) Nasim Sabouri et al.   BMC BIOLOGY

Dicer Promotes Transcription Termination at Sites of Replication Stress to Maintain Genome Stability

(2014) Stephane E. Castel et al.   CELL

Mta2 promotes Tipin-dependent maintenance of replication fork integrity

(2014) Alessia Errico et al.   CELL CYCLE

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

G4 motifs affect origin positioning and efficiency in two vertebrate replicators

(2014) A.-L. Valton et al.   EMBO JOURNAL

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Separation of replication and transcription domains in nucleoli

(2014) E. Smirnov et al.   JOURNAL OF STRUCTURAL BIOLOGY

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions

(2014) José M. Santos-Pereira et al.   NUCLEIC ACIDS RESEARCH

Serial number tagging reveals a prominent sequence preference of retrotransposon integration

(2014) Atreyi Ghatak Chatterjee et al.   NUCLEIC ACIDS RESEARCH

Intramolecular Telomeric G-Quadruplexes Dramatically Inhibit DNA Synthesis by Replicative and Translesion Polymerases, Revealing their Potential to Lead to Genetic Change

(2014) Deanna N. Edwards et al.   PLoS One

Transcription and Recombination: When RNA Meets DNA

(2014) A. Aguilera et al.   Cold Spring Harbor Perspectives in Biology

At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1

(2014) Akila Sridhar et al.   PLoS Genetics

Rad51–Rad52 Mediated Maintenance of Centromeric Chromatin in Candida albicans

(2014) Sreyoshi Mitra et al.   PLoS Genetics

Portrait of replication stress viewed from telomeres

(2013) Fuyuki Ishikawa   CANCER SCIENCE

Transcription-Associated Genome Instability

(2013) Hélène Gaillard et al.   CHEMICAL REVIEWS

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat

(2013) T. Jakociunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases

(2013) W.-H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication Fork Stability Is Essential for the Maintenance of Centromere Integrity in the Absence of Heterochromatin

(2013) Pao-Chen Li et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

(2013) Adam Leman et al.   Genes

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Human Transposon Tectonics

(2012) Kathleen H. Burns et al.   CELL

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres

(2012) Adam R. Leman et al.   CELL CYCLE

Local and global functions of Timeless and Tipin in replication fork protection

(2012) Adam R. Leman et al.   CELL CYCLE

Replication stress and genome rearrangements: lessons from yeast models

(2012) Sarah Lambert et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability

(2012) R. Steinacher et al.   GENES & DEVELOPMENT

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

(2012) N. Sabouri et al.   GENES & DEVELOPMENT

Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae

(2012) E. Cheng et al.   GENETICS

Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots

(2012) L. Mularoni et al.   GENOME RESEARCH

A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon

(2012) J. A. Baller et al.   GENOME RESEARCH

Replication Fork Stalling and Checkpoint Activation by aPKD1Locus Mirror Repeat Polypurine-Polypyrimidine (Pu-Py) Tract

(2012) Guoqi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human telomeres replicate using chromosome-specific, rather than universal, replication programs

(2012) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transposon integration enhances expression of stress response genes

(2012) Gang Feng et al.   NUCLEIC ACIDS RESEARCH

Lsd1 and Lsd2 Control Programmed Replication Fork Pauses and Imprinting in Fission Yeast

(2012) Allyson Holmes et al.   Cell Reports

tRNA genes in eukaryotic genome organization and reorganization

(2011) Ramsay J. McFarlane et al.   CELL CYCLE

S. pombereplication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein

(2011) Pao-Chen Li et al.   CELL CYCLE

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

(2011) Avvaru N Suhasini et al.   EMBO JOURNAL

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization

(2011) A. Tsankov et al.   GENOME RESEARCH

DNA replication initiation patterns and spatial dynamics of the human ribosomal RNA gene loci

(2011) D. S. Dimitrova   JOURNAL OF CELL SCIENCE

The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?

(2011) Matthew L. Bochman et al.   MOLECULAR BIOLOGY OF THE CELL

RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

(2011) Mikel Zaratiegui et al.   NATURE

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components

(2011) Peter C. Stirling et al.   PLoS Genetics

Regulation of Replication Termination by Reb1 Protein-Mediated Action at a Distance

(2010) Samarendra K. Singh et al.   CELL

Tension Management in the Kinetochore

(2010) Kerry Bloom et al.   CURRENT BIOLOGY

Transcription-Associated Mutation in Bacillus subtilis Cells under Stress

(2010) C. Pybus et al.   JOURNAL OF BACTERIOLOGY

Replication Fork Arrest and rDNA Silencing Are Two Independent and Separable Functions of the Replication Terminator Protein Fob1 of Saccharomyces cerevisiae

(2010) Narendra K. Bairwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress

(2010) L. Rodriguez-Sanchez et al.   JOURNAL OF CELL SCIENCE

CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR

(2010) Mikel Zaratiegui et al.   NATURE

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

(2010) T. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements

(2010) Samantha Kendrick et al.   PURE AND APPLIED CHEMISTRY

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

(2010) Sophie Rozenzhak et al.   PLoS Genetics

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Stimulation of direct-repeat recombination by RNA polymerase III transcription

(2009) M.C. Díaz de la Loza et al.   DNA REPAIR

Contrasting Roles of Checkpoint Proteins as Recombination Modulators at Fob1-TerComplexes with or without Fork Arrest

(2009) Bidyut K. Mohanty et al.   EUKARYOTIC CELL

High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe

(2009) Y. Guo et al.   GENOME RESEARCH

Models for chromosomal replication-independent non-B DNA structure-induced genetic instability

(2009) Guliang Wang et al.   MOLECULAR CARCINOGENESIS

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus

(2009) Makoto T. Hayashi et al.   NATURE CELL BIOLOGY

Origin-dependent initiation of DNA replication within telomeric sequences

(2009) Isabel Kurth et al.   NUCLEIC ACIDS RESEARCH

Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1

(2009) D. W. Pryce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

Rtf1-Mediated Eukaryotic Site-Specific Replication Termination

(2008) T. Eydmann et al.   GENETICS

Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication

(2008) Karen A. Urtishak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absolute Gene Occupancies by RNA Polymerase III, TFIIIB, and TFIIIC inSaccharomyces cerevisiae

(2008) Elisabetta Soragni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

Reduced Levels of DNA Polymerase   Induce Chromosome Fragile Site Instability in Yeast

(2008) F. J. Lemoine et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanistic Insights into Replication Termination as Revealed by Investigations of the Reb1-Ter3 Complex of Schizosaccharomyces pombe

(2008) S. Biswas et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Double-strand breaks associated with repetitive DNA can reshape the genome

(2008) J. L. Argueso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA