Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks

R.I.P. to the PIP: PCNA-binding motif no longer considered specific

(2016) Elizabeth M. Boehm et al.   BIOESSAYS

Mcm10: The glue at replication forks

(2016) Anja-Katrin Bielinsky   CELL CYCLE

Xenopus Mcm10 is a CDK-substrate required for replication fork stability

(2016) Gaganmeet Singh Chadha et al.   CELL CYCLE

MCM: one ring to rule them all

(2016) Tom D Deegan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

(2016) Alex B Wang et al.   EMBO JOURNAL

An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation

(2016) Patricia Perez-Arnaiz et al.   JOURNAL OF MOLECULAR BIOLOGY

Replicating Large Genomes: Divide and Conquer

(2016) Juan Carlos Rivera-Mulia et al.   MOLECULAR CELL

Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells

(2016) YI-XIANG LIAO et al.   Molecular Medicine Reports

Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation

(2016) Nicole Vo et al.   NUCLEIC ACIDS RESEARCH

Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase

(2016) Mohammed Al Mamun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Polymerases Divide the Labor of Genome Replication

(2016) Scott A. Lujan et al.   TRENDS IN CELL BIOLOGY

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression

(2016) Yee Mon Thu et al.   Cell Reports

Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p

(2016) Zofia Wotschofsky et al.   PLoS One

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease

(2015) Wanwen Lan et al.   CELL CYCLE

RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells

(2015) Jun-Sub Im et al.   CELL CYCLE

Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle

(2015) S. K. Powell et al.   EMBO JOURNAL

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest

(2015) Bizhan Romani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex

(2015) Max E. Douglas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

Crystal structure of the eukaryotic origin recognition complex

(2015) Franziska Bleichert et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mcm10 coordinates the timely assembly and activation of the replication fork helicase

(2015) Patricia Perez-Arnaiz et al.   NUCLEIC ACIDS RESEARCH

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

(2015) Maciej Kliszczak et al.   Oncotarget

Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase

(2015) Yun Quan et al.   Cell Reports

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair

(2014) Jordan R Becker et al.   CELL CYCLE

The contribution of dormant origins to genome stability: From cell biology to human genetics

(2014) Robert C. Alver et al.   DNA REPAIR

Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication

(2014) K. F. On et al.   EMBO JOURNAL

The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-stranded DNA Extrusion and Helicase Assembly

(2014) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

(2014) Chuanhe Yu et al.   MOLECULAR CELL

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

(2014) Constance Alabert et al.   NATURE CELL BIOLOGY

The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage

(2014) Robert C. Alver et al.   NUCLEIC ACIDS RESEARCH

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MCM10: One tool for all—Integrity, maintenance and damage control

(2014) Yee Mon Thu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Impaired p32 Regulation Caused by the Lymphoma-Prone RECQ4 Mutation Drives Mitochondrial Dysfunction

(2014) Jiin-Tarng Wang et al.   Cell Reports

The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability

(2014) Benoit Miotto et al.   Cell Reports

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells

(2014) Franck Picard et al.   PLoS Genetics

The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties

(2013) Roberta Di Perna et al.   BIOCHEMICAL JOURNAL

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

(2013) R. L. Ragland et al.   GENES & DEVELOPMENT

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

(2013) Timothy J. Newman et al.   NUCLEIC ACIDS RESEARCH

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation

(2013) Samuel T. Fatoba et al.   NUCLEIC ACIDS RESEARCH

Mcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil Domain

(2013) Wenyue Du et al.   PLoS One

Over Expression of Minichromosome Maintenance Genes is Clinically Correlated to Cervical Carcinogenesis

(2013) Mitali Das et al.   PLoS One

Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer

(2013) Guhyun Kang et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Enigmatic roles of Mcm10 in DNA replication

(2013) Yee Mon Thu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Integrating gene expression and protein-protein interaction network to prioritize cancer-associated genes

(2012) Chao Wu et al.   BMC BIOINFORMATICS

Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS

(2012) George Watase et al.   CURRENT BIOLOGY

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

(2012) Mai Kanke et al.   EMBO JOURNAL

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

(2012) Manpreet Kaur et al.   NUCLEIC ACIDS RESEARCH

New insights into replisome fluidity during chromosome replication

(2012) Isabel Kurth et al.   TRENDS IN BIOCHEMICAL SCIENCES

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality

(2011) Han Jeong Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

(2011) Seiji Tanaka et al.   CURRENT BIOLOGY

Mcm10 interacts with Rad4/Cut5TopBP1 and its association with origins of DNA replication is dependent on Rad4/Cut5TopBP1

(2011) Mark Taylor et al.   DNA REPAIR

Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast

(2011) Tamon Tanaka et al.   EMBO JOURNAL

Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells

(2011) Christoph Weber et al.   Journal of Proteomics

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

How dormant origins promote complete genome replication

(2011) J. Julian Blow et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes

(2010) J. Sun et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

(2010) Wojciech Strzalka et al.   ANNALS OF BOTANY

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast

(2010) Jiafeng Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mcm10 proteolysis initiates before the onset of M-phase

(2010) Manpreet Kaur et al.   BMC CELL BIOLOGY

CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol  , and GINS in budding yeast

(2010) S. Muramatsu et al.   GENES & DEVELOPMENT

Solution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM Motif

(2010) Patrick D. Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Lagging Strand DNA Replication Employs a Multi-pathway Mechanism That Protects Genome Integrity

(2010) Lata Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultraviolet Radiation Stress Triggers the Down-regulation of Essential Replication Factor Mcm10

(2010) Aparna Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

(2009) Xiaohua Xu et al.   EMBO JOURNAL

The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

(2009) Mireille Tittel-Elmer et al.   EMBO JOURNAL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Novel DNA Binding Properties of the Mcm10 Protein from Saccharomyces cerevisiae

(2009) Shlomo Eisenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Interactions between Mcm10, DNA, and DNA Polymerase α

(2009) Eric M. Warren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth

(2009) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase

(2009) M. L. Bochman et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Alternative Mechanisms for Coordinating Polymerase   and MCM Helicase

(2009) C. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Motif-Specific Sampling of Phosphoproteomes

(2008) Cristian I. Ruse et al.   JOURNAL OF PROTEOME RESEARCH

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

(2008) E García-Aragoncillo et al.   ONCOGENE

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for DNA Binding by Replication Initiator Mcm10

(2008) Eric M. Warren et al.   STRUCTURE

Knockdown of human MCM10 exhibits delayed and incomplete chromosome replication

(2007) Jong Hoon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Knockdown of human MCM10 activates G2 checkpoint pathway

(2007) Jong Hoon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS