CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

An interview with Dr. Catherine Transy and Dr. Florence Margottin-Goguet on their highly cited paper published inCell Cycle

(2011) Catherine Transy   CELL CYCLE

Mcm10 proteolysis initiates before the onset of M-phase

(2010) Manpreet Kaur et al.   BMC CELL BIOLOGY

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

(2010) Laurieann Casey et al.   CYTOKINE

Specific replication factors are targeted by different genotoxic agents to inhibit replication

(2010) Aparna Sharma et al.   IUBMB LIFE

Ultraviolet Radiation Stress Triggers the Down-regulation of Essential Replication Factor Mcm10

(2010) Aparna Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation

(2010) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting protein ubiquitylation: DDB1 takes its RING off

(2009) Sarah Jackson et al.   NATURE CELL BIOLOGY

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

(2008) Y. Kim et al.   GENES & DEVELOPMENT

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2Pathway during S Phase and after UV Irradiation

(2008) Hideo Nishitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development

(2008) C. M. McCall et al.   MOLECULAR AND CELLULAR BIOLOGY

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

(2008) J Huang et al.   ONCOGENE

Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes

(2008) Y. Zhang et al.   PLANT CELL