The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-stranded DNA Extrusion and Helicase Assembly

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

Crystal Structure of the Homology Domain of the Eukaryotic DNA Replication Proteins Sld3/Treslin

(2014) Hiroshi Itou et al.   STRUCTURE

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

(2014) Alessandro Costa et al.   eLife

A conserved MCM single-stranded DNA binding element is essential for replication initiation

(2014) Clifford A Froelich et al.   eLife

Cdc45 Protein-Single-stranded DNA Interaction Is Important for Stalling the Helicase during Replication Stress

(2013) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Replication Initiation Protein Sld2 Regulates Helicase Assembly

(2013) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions with Distinct Mcm2–7 Protein Subunits

(2013) Matthew D. Ramer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mcm2 phosphorylation and the response to replicative stress

(2012) Brent E Stead et al.   BMC GENETICS

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

(2011) Seiji Tanaka et al.   CURRENT BIOLOGY

Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2–7 Complex, Allowing the GINS Tetramer to Bind the Mcm2–7 Complex

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2–7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage

(2011) Brent E. Stead et al.   NUCLEIC ACIDS RESEARCH

Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication

(2010) Hiroyuki Araki   CURRENT OPINION IN CELL BIOLOGY

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing

(2010) Diane M. Kanter et al.   NUCLEIC ACIDS RESEARCH

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’

(2010) Matthew L. Bochman et al.   NUCLEIC ACIDS RESEARCH

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth

(2009) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability

(2008) M. L. Bochman et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL