Regulation and Modulation of Human DNA Polymerase δ Activity and Function

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

(2017) Christoph F. Kurat et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

(2017) Katherine N. Choe et al.   MOLECULAR CELL

CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

(2017) Jin Chuan Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork

(2017) Grant D. Schauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent exchange of the DNA polymerase during bacterial chromosome replication

(2017) Thomas R Beattie et al.   eLife

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

(2017) Ryan Barnes et al.   Genes

PrimPol—Prime Time to Reprime

(2017) Thomas Guilliam et al.   Genes

The Eukaryotic Replisome Goes Under the Microscope

(2016) Mike O’Donnell et al.   CURRENT BIOLOGY

POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies

(2016) Emmanuelle Nicolas et al.   GENE

The RNA Response to DNA Damage

(2016) Luciana E. Giono et al.   JOURNAL OF MOLECULAR BIOLOGY

POLD3 Is Haploinsufficient for DNA Replication in Mice

(2016) Matilde Murga et al.   MOLECULAR CELL

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

(2016) Fabrizio Villa et al.   MOLECULAR CELL

PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities

(2016) Thomas A. Guilliam et al.   NUCLEIC ACIDS RESEARCH

Strand displacement synthesis by yeast DNA polymerase ε

(2016) Rais A. Ganai et al.   NUCLEIC ACIDS RESEARCH

Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

(2016) Mark Hedglin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ

(2016) Xiaoxiao Wang et al.   Oncotarget

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

(2016) Olga Yurieva et al.   Nucleus

DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair

(2016) Elisa Mentegari et al.   Genes

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

(2016) Olga Yurieva et al.   Nucleus

Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

(2015) Faizan H. Khan et al.   BMC CANCER

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants

(2015) Dragony Fu et al.   DNA REPAIR

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B

(2015) Jeffrey Hannah et al.   GENE

Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork

(2015) Hang Phuong Le et al.   GENES TO CELLS

Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing

(2015) Gina Kavanaugh et al.   MOLECULAR AND CELLULAR BIOLOGY

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ

(2015) Kouji Hirota et al.   NUCLEIC ACIDS RESEARCH

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

(2015) Zbigniew Darzynkiewicz et al.   Oncotarget

Enhancer of rudimentary homolog regulates DNA damage response in hepatocellular carcinoma

(2015) Meng-Tzu Weng et al.   Scientific Reports

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

(2015) Chiara Naro et al.   Frontiers in Genetics

Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization

(2014) Srinivasa Raju Datla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structure–Function Studies of DNA Polymerase λ

(2014) Katarzyna Bebenek et al.   BIOCHEMISTRY

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway

(2014) Qinmiao Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells

(2014) Hong Zhao et al.   CELL CYCLE

Poldip2 Knockout Results in Perinatal Lethality, Reduced Cellular Growth and Increased Autophagy of Mouse Embryonic Fibroblasts

(2014) David I. Brown et al.   PLoS One

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Polymerase Delta Interacting Protein 2 Sustains Vascular Structure and Function

(2013) Roy L. Sutliff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2

(2013) Agnes Wong et al.   CELL CYCLE

The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

(2013) Marietta Y.W.T. Lee et al.   CELL CYCLE

Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ

(2013) Szu Hua Sharon Lin et al.   DNA REPAIR

A Novel Function of CRL4Cdt2

(2013) Sufang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of p12 Subunit by CRL4Cdt2E3 Ligase Inhibits Fork Progression after DNA Damage

(2013) Kenta Terai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

(2013) Agathe Bacquin et al.   NUCLEIC ACIDS RESEARCH

Identification of Amino Acid Residues of ERH Required for Its Recruitment to Nuclear Speckles and Replication Foci in HeLa Cells

(2013) Monika I. Banko et al.   PLoS One

DNA polymerase  -interacting protein 2 is a processivity factor for DNA polymerase   during 8-oxo-7,8-dihydroguanine bypass

(2013) G. Maga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase

(2013) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

Okazaki Fragment Metabolism

(2013) L. Balakrishnan et al.   Cold Spring Harbor Perspectives in Biology

The enigmatic ERH protein: its role in cell cycle, RNA splicing and cancer

(2013) Meng-Tzu Weng et al.   Protein & Cell

Pre-mRNA processing factors meet the DNA damage response

(2013) Alessandra Montecucco et al.   Frontiers in Genetics

Structure of monoubiquitinated PCNA

(2012) Zhongtao Zhang et al.   CELL CYCLE

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage

(2012) Jennifer Chea et al.   CELL CYCLE

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation

(2012) Thomas R Beattie et al.   EMBO JOURNAL

DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors

(2012) Beverly A. Baptiste et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Regulation of human DNA polymerase delta in the cellular responses to DNA damage

(2012) Marietta Y.W.T. Lee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

(2012) Sufang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

(2012) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

(2012) Courtney G. Havens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Human DNA Polymerase Delta and Its Subassemblies Reconstituted by Expression in the Multibac System

(2012) Yajing Zhou et al.   PLoS One

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA

(2012) Karin M. Gilljam et al.   PLoS One

Pol31 and Pol32 subunits of yeast DNA polymerase   are also essential subunits of DNA polymerase  

(2012) R. E. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch To Regulate Its Interaction with PCNA

(2011) Amal A. Rahmeh et al.   BIOCHEMISTRY

Ubiquitination of PCNA and Its Essential Role in Eukaryotic Translesion Synthesis

(2011) Junjun Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation

(2011) Esther Klaile et al.   CELL CYCLE

It’s all about flaps

(2011) Peter M. Burgers   CELL CYCLE

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

DNA replication and repair bypass machines

(2011) Ulrich Hübscher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

(2011) Vladimir P. Bermudez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

(2011) Suzanne E. Hile et al.   NUCLEIC ACIDS RESEARCH

P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA

(2011) Yujue Wang et al.   PLoS One

The emerging role of pre-messenger RNA splicing in stress responses: Sending alternative messages and silent messengers

(2011) Martin Dutertre et al.   RNA Biology

The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis

(2010) Xiao Meng et al.   BIOCHEMISTRY

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

PCNA is ubiquitinated by RNF8

(2010) Sufang Zhang et al.   CELL CYCLE

Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Polη

(2010) Agnès Tissier et al.   DNA REPAIR

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

(2010) Gastón Soria et al.   DNA REPAIR

Assembly and function of DNA double-strand break repair foci in mammalian cells

(2010) Simon Bekker-Jensen et al.   DNA REPAIR

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts

(2010) Elena K. Braithwaite et al.   PLoS One

Genome-wide model for the normal eukaryotic DNA replication fork

(2010) Andres A. Larrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR: a master conductor of cellular responses to DNA replication stress

(2010) Rachel Litman Flynn et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells

(2009) Qin Miao Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA polymerase proofreading: Multiple roles maintain genome stability

(2009) Linda J. Reha-Krantz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The human intra-S checkpoint response to UVC-induced DNA damage

(2009) William K. Kaufmann   CARCINOGENESIS

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

(2009) Jeffrey Hannah et al.   DNA REPAIR

MDM2 and MDM4 splicing: an integral part of the cancer spliceome

(2009) Selvi Jeyaraj   Frontiers in Bioscience-Landmark

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human DNA Polymerase   Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

(2009) L. Rey et al.   MOLECULAR AND CELLULAR BIOLOGY

Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome

(2009) Kristin A. Eckert et al.   MOLECULAR CARCINOGENESIS

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein Phosphatase-1 Is Targeted to DNA Polymerase δ via an Interaction with the p68 Subunit†

(2008) Yan Gao et al.   BIOCHEMISTRY

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites

(2008) Jun Yan et al.   CANCER LETTERS

SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

DNA Polymerase δ Is Highly Processive with Proliferating Cell Nuclear Antigen and Undergoes Collision Release upon Completing DNA

(2008) Lance D. Langston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH