CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

(2017) Christoph F. Kurat et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

(2017) Roxana Georgescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Who Is Leading the Replication Fork, Pol ε or Pol δ?

(2016) Peter M.J. Burgers et al.   MOLECULAR CELL

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New Insights into the Mechanism of DNA Duplication by the Eukaryotic Replisome

(2016) Luca Pellegrini et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure of human Cdc45 and implications for CMG helicase function

(2016) Aline C. Simon et al.   Nature Communications

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

(2016) Ferdos Abid Ali et al.   Nature Communications

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The eukaryotic CMG helicase pumpjack and integration into the replisome

(2016) Jingchuan Sun et al.   Nucleus

The eukaryotic CMG helicase pumpjack and integration into the replisome

(2016) Jingchuan Sun et al.   Nucleus

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

(2015) Bruce Stillman   MOLECULAR CELL

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The architecture of a eukaryotic replisome

(2015) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The architecture of a eukaryotic replisome

(2015) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

(2015) Roxana E Georgescu et al.   eLife

Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

(2014) Chuanhe Yu et al.   MOLECULAR CELL

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

(2014) Aline C. Simon et al.   NATURE

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

(2014) Roxana E Georgescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability

(2012) Isabelle Isoz et al.   NUCLEIC ACIDS RESEARCH

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase   in rolling circle DNA synthesis

(2012) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Choreography of bacteriophage T7 DNA replication

(2011) Seung-Joo Lee et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

(2011) Izumi Miyabe et al.   PLoS Genetics

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The eukaryotic replicative DNA polymerases take shape

(2010) Erik Johansson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

(2009) Tahir H Tahirov et al.   Biology Direct

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL