Article
Oncology
Yu Zhang, Weipeng Chen, Xin Cheng, Feiran Wang, Cheng Gao, Fei Song, Fengliang Song, Xiaoliang Liang, Wanzhi Fang, Zhong Chen
Summary: High expression of SMPDL3A in HCC was associated with poor prognosis. Knockout of SMPDL3A inhibited cell proliferation and migration in HCC cells. SMPDL3A interacted with ERH to affect the tumorigenesis and progression of HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheol Park, Won Sup Lee, Se-Il Go, Sang-Ho Jeong, Jiyun Yoo, Hee-Jae Cha, Young-Joon Lee, Heui-Soo Kim, Sun-Hee Leem, Hye Jung Kim, Gon Sup Kim, Soon-Chan Hong, Yung Hyun Choi
Summary: The study found that enhanced expression of the ERH gene can augment the anticancer efficacy of anthocyanins in gastric cancer cells, potentially through increased expression of pro-apoptotic proteins and elevated ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yi Chen, Mengjia Huang, Junkai Zhu, Li Xu, Wenxuan Cheng, Xiaofan Lu, Fangrong Yan
Summary: In this study, a novel DDR-related gene pair signature and nomogram were developed to predict survival outcomes and guide clinical treatment for HCC patients. The research also provides insights into the underlying mechanisms of different DDR patterns in HCC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Na Qiang, Junjie Ao, Masato Nakamura, Tetsuhiro Chiba, Yuko Kusakabe, Tatsuya Kaneko, Akane Kurosugi, Tadayoshi Kogure, Yaojia Ma, Jiaqi Zhang, Keita Ogawa, Motoyasu Kan, Terunao Iwanaga, Takafumi Sakuma, Kengo Kanayama, Hiroaki Kanzaki, Ryuta Kojima, Ryo Nakagawa, Takayuki Kondo, Shingo Nakamoto, Ryosuke Muroyama, Jun Kato, Naoya Mimura, Anqi Ma, Jian Jin, Naoya Kato
Summary: Enhancer of zeste homolog 2 (EZH2), an overexpressed therapeutic target molecule in various cancers, has immunomodulatory functions in the tumor microenvironment (TME). This study evaluated the impact of EZH2 on TME of hepatocellular carcinoma (HCC) and found that EZH2 inhibitor impaired tumor growth but its effect was weakened in immunocompetent mice. Combining EZH2 inhibitors with agents that reduce MDSCs might represent a novel therapeutic strategy for HCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Miaoqin Chen, Weikai Wang, Shiman Hu, Yifan Tong, Yiling Li, Qi Wei, Lei Yu, Liyuan Zhu, Yiran Zhu, Leiming Liu, Zhenyu Ju, Xian Wang, Hongchuan Jin, Lifeng Feng
Summary: High expression of WIP1 is associated with poor prognosis in patients with HCC. Inhibition of WIP1 and PARP induces synthetic lethality in HCC by augmenting DNA damage.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Peng Huang, Bin Zhang, Junsheng Zhao, Ming D. Li
Summary: This study identifies aberrant enhancers and associated transcriptional dysregulation in hepatocellular carcinoma (HCC) using integrative analysis of various DNA sequencing data. The study also explores the functions and clinical significance of these aberrant enhancers. Furthermore, a prognostic signature based on aberrant enhancers is established with excellent predictive accuracy for overall survival of HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Valli De Re, Anna Rossetto, Alessandro Rosignoli, Elena Muraro, Vito Racanelli, Maria Lina Tornesello, Aron Zompicchiatti, Alessandro Uzzau
Summary: Ablative and locoregional treatment options are effective therapies for early-stage HCC, enhancing immunogenicity and survival rates. Surgical approaches combined with immune-modulating drugs show promise in maximizing therapeutic outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tingting Lu, Tao Han, Mingfang Zhao
Summary: miR-3168 is increased in liver cancer stem cells (CSCs) and inhibits CSC expansion by targeting p53 directly. Additionally, miR-3168 may be a predictor of survival benefits from transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. The study uncovers a novel mechanism of liver CSC regulation and provides a potential therapeutic target for liver CSCs.
Article
Biochemistry & Molecular Biology
Jin Cai, Ningchao Wang, Guanglan Lin, Haowei Zhang, Weidong Xie, Yaou Zhang, Naihan Xu
Summary: RNA-binding protein MBNL2 plays a crucial role in regulating tumor cell proliferation and DNA damage response by modulating the PI3K/AKT pathway and affecting the expression of p21. Depletion of MBNL2 leads to increased phosphorylation levels of Chk1 and influences DNA damage response, ultimately altering tumor cell fate by inhibiting DNA damage repair and promoting DNA damage-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Guosheng Lyu, Peng Sue, Xiaohe Hao, Shiming Chen, Shuai Ren, Zixiao Zhao, Yaoqin Gong, Qiao Liu, Changshun Shao
Summary: RECQL4 is highly expressed in ESCC and is associated with poor differentiation, enhanced invasion, and metastasis. It promotes cell proliferation and migration, regulates DNA damage, redox homeostasis, and cell survival.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tzu-Yue Shiu, Hsuan-Hwai Lin, Yu-Lueng Shih, An-Chieh Feng, Hsin-Hung Huang, Tien-Yu Huang, Chung-Bao Hsieh, Wei-Kuo Chang, Tsai-Yuan Hsieh
Summary: This study identified miR-136-5p as a direct regulator of ILF2 in HCC and showed that the lncRNA CRNDE-h/miR-136-5p/ILF2 axis plays a significant role in the progression of HCC, potentially providing new targets for diagnosis, treatment, and prognosis of HCC.
Article
Biochemistry & Molecular Biology
Seamus Balinth, Matthew L. Fisher, Yon Hwangbo, Caizhi Wu, Carlos Ballon, Xueqin Sun, Alea A. Mills
Summary: This study reveals the crucial roles of EZH2 and SETDB1 in the stem cell phenotype of squamous cell carcinoma (SCC) and their regulation through interactions with Delta Np63 alpha and RUNX3.
Article
Biology
Swathy Babu, Yuki Takeuchi, Ichiro Masai, Katharina Schlacher
Summary: Banp plays crucial roles in DNA damage response and chromosome segregation, especially during embryonic development. It regulates cell cycle progression and cell survival by controlling DNA replication and DNA damage repair.
Article
Oncology
Peng Huang, Mengxiang Xu, Haijun Han, Xinyi Zhao, Ming D. Li, Zhongli Yang
Summary: DNA methylation plays a crucial role in regulating gene expression in hepatocellular carcinoma (HCC). This study identified a large number of differentially methylated CpG sites in HCC and highlighted the activation of cell cycle-related pathways and repression of metabolic pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jingjing Zhang, Qiong Wu, Lucheng Zhu, Shujun Xie, Linglan Tu, Yuhong Yang, Kan Wu, Yanyan Zhao, Yuqing Wang, Yasi Xu, Xueqin Chen, Shenglin Ma, Shirong Zhang
Summary: SERPINE2 is identified as a regulator of radiosensitivity and the DNA damage response (DDR) in lung cancer, with knockdown improving tumor radiosensitivity by reducing homologous recombination repair, restoring cell cycle checkpoints, and suppressing migration and invasion. Additionally, high SERPINE2 expression correlates with poor prognosis and a high serum concentration predicts a poor response to radiotherapy in lung cancer patients.
Article
Chemistry, Multidisciplinary
Jhih-Guang Wu, Shu-Chen Wei, Shyh-Chyang Luo
ADVANCED MATERIALS INTERFACES
(2020)
Article
Gastroenterology & Hepatology
Yu-Chen Pai, Li-Ting Weng, Shu-Chen Wei, Li-Ling Wu, David Q. Shih, Stephen R. Targan, Jerrold R. Turner, Linda Chia-Hui Yu
Summary: This study demonstrated the upregulation of TL1A, IFN gamma, and two MLCK variants in human IBD biopsy specimens. TL1A was found to induce MLCK-dependent changes in gut barrier function and bacterial internalization. Different MLCK isoforms were shown to orchestrate divergent pathways of bacterial infiltration in IBD, suggesting a potential mechanism for symptom flares in the disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Rupa Banerjee, Raja Affendi Raja Ali, Shu Chen Wei, Shashi Adsul
Article
Gastroenterology & Hepatology
Ji Min Lee, Shu-Chen Wei, Kang-Moon Lee, Byong Duk Ye, Ren Mao, Hyun-Soo Kim, Soo Jung Park, Sang Hyoung Park, Eun Hye Oh, Jong Pil Im, Byung Ik Jang, Dae Bum Kim, Ken Takeuchi
Summary: This study investigated the clinical course and liver dysfunction risks in HBV-infected IBD patients undergoing anti-TNF-alpha therapy. The results showed that liver dysfunction due to HBV reactivation was more common in patients with chronic HBV infection. Antiviral prophylaxis significantly reduced the risk of liver dysfunction in patients with chronic HBV infection.
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, I-Lun Shih, Chien-Chih Tung, Yew-Loong Leong, Ming-Jium Shieh, Cheng-Yi Wang, Jau-Min Wong, Yen-Hsuan Ni, Shu-Chen Wei
Summary: This study aimed to evaluate the prevalence, clinical manifestation, and outcomes of primary sclerosing cholangitis (PSC) in Taiwanese patients with inflammatory bowel disease (IBD). The results showed a prevalence rate of 1.57% for PSC in Taiwanese IBD patients. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W. Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ajuja, Nicola Panaccione, Abdel-Azi Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabian Juliao-Banos, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao, Maojuan Li
Summary: This study investigates the hospitalization rates of inflammatory bowel disease (IBD) in different regions of the world and finds that while the rates are stabilizing in developed countries, they are rapidly increasing in newly industrialized countries, leading to a growing burden on global healthcare systems.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Cheng-Tzu Hsieh, Meng-Tzu Weng, Chien-Chih Tung, Nai-Chia Chen, Hui-Chuen Chen, Kuo-Liong Chien, Shu-Chen Wei
Summary: This survey focused on the dietary beliefs, practices, and information resources of Taiwanese UC patients in clinical remission. It found that a majority of patients believed diet could trigger UC and avoided specific foods to prevent relapses, with spicy foods being the most commonly avoided. Information resources mainly came from patients' own experiences.
CLINICAL NUTRITION ESPEN
(2022)
Review
Gastroenterology & Hepatology
Chun-Chi Lin, Hung-Hsin Lin, Hui-Chuen Chen, Nai-Chia Chen, I-Lun Shih, Ji-Shiang Hung, Te-Cheng Yueh, Feng-Fan Chiang, Ping-Wei Lin, Yuan-Yao Tsai, Shu-Chen Wei
Summary: Crohn's disease is a chronic inflammatory disease that primarily affects the gastrointestinal tract. Both medical treatment and surgical intervention may be necessary for its management. Nutritional optimization and ERAS implementation are crucial in reducing postoperative complications, while the risks and strategies related to medication and surgery should be individualized based on each case.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Medicine, General & Internal
Po -Yen Hsiao, Meng-Tzu Weng, Chin-Hao Chang, Ling-Yun Huang, Chien-Chih Tung, Yew-Loong Leong, Ming-Jium Shieh, Jau-Min Wong, Shu-Chen Wei
Summary: This study found that the screening rate for anemia in inflammatory bowel disease (IBD) patients in Taiwan has increased over the years. Anemia is associated with worse outcomes, and early investigation and treatment of anemia in IBD patients are recommended.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yen-Ling Peng, Chung-Hsin Chang, Shu-Chen Wei, Tien-Yu Huang, Wei-Chen Tai, Wen-Hung Hsu, Deng-Chyang Wu, Hsu-Heng Yen, Chi-Ming Tai, Chen-Wang Chang, Wei-Chen Lin, Horng-Yuan Wang, Chun-Chi Lin, Chia-Jung Kuo, Cheng-Tang Chiu, Ching-Pin Lin, Hsi-Chang Lee, Jia-Feng Wu, Chen-Shuan Chung
Summary: This study evaluated the impact of the COVID-19 pandemic on the perceptions of patients with inflammatory bowel disease (IBD). The results showed that patients were concerned about adverse events from vaccination, higher risks of developing severe COVID-19, and COVID-19 infection compared to the general population. Some patients self discontinued IBD medication during the pandemic, leading to worse symptoms. However, after receiving education, the anxiety levels of the patients were mitigated.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Su Bum Park, Kyeong Ok Kim, Hong Sub Lee, Chang Hwan Choi, Shu Chen Wei, Min Hu Chen, Katsuyoshi Matsuoka
Summary: This study investigated the current approaches and practices of physicians regarding vaccinations for inflammatory bowel disease (IBD) patients in different Asian countries/regions. The results showed similarities among countries/regions in terms of recognizing the importance of vaccination, but there were differences in the selection and recommendation of certain vaccines, reflecting each country's vaccination guidelines and health insurance. Therefore, more communication among doctors and a consensus regarding IBD vaccination differences in the Asian region are needed.
INTESTINAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, Kuan-Lin Lin, Ya-Ling Huang, Chitra Karki, Jin-Liern Hong, Dimitri Bennett, K. Arnold Chan, Shu-Chen Wei
Summary: The prevalence of pCD in Taiwanese CD patients is 14.8%, with half of them being diagnosed before CD and one-third experiencing recurrence. Although pCD patients have higher healthcare utilization, their 15-year mortality rate is lower than those without pCD.
CROHNS & COLITIS 360
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei-En Lee, Meng-Tzu Weng, Shu-Chen Wei, I-Lun Shih
Summary: This study compared the diagnostic accuracy of three different scoring methods for assessing Crohn's disease activity and found that the sMaRIA and Nancy scores are comparable to the MaRIA score. These alternative scoring methods could be used in clinical practice, especially for disease monitoring.
ABDOMINAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Khoon Lin Ling, Ida Hilmi, Raja Affendi Raja Ali, Rupert W. L. Leong, Wai Keung Leung, Siew Chien Ng, Kai Chun Wu, Min Hu Chen, Zhi Hua Ran, Tadakazu Hisamatsu, Vineet Ahuja, Govind K. Makharia, Rupa Banerjee, Shu Chen Wei, Deng Chyang Wu, Pises Pisespongsa, Byong Duk Ye, Jose Sollano, Marcellus Simadibrata, Sai Wei Chuah, Choon Jin Ooi
Review
Gastroenterology & Hepatology
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K. Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H. De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert W. L. Leong
INTESTINAL RESEARCH
(2019)
