Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

(2015) J.-i. Okada et al.   Science Advances

The effects of six antipsychotic agents on QTc—An attempt to mimic clinical trial through simulation including variability in the population

(2014) Anna Glinka et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges

(2014) B. Wi niowska et al.   EUROPACE

In vitro to human in vivo translation – pharmacokinetics and pharmacodynamics of quinidine

(2014) Sebastian Polak   ALTEX-Alternatives to Animal Experimentation

In vitro–in vivo extrapolation of drug-induced proarrhythmia predictions at the population level

(2013) Sebastian Polak et al.   DRUG DISCOVERY TODAY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions

(2011) J. Carro et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

M Cells in the Human Heart

(2010) Charles Antzelevitch   CIRCULATION RESEARCH

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS