hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

(2012) Giovanni Y. Di Veroli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment

(2011) M. R. Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Multiscale Investigation of Repolarization Variability and Its Role in Cardiac Arrhythmogenesis

(2011) Esther Pueyo et al.   BIOPHYSICAL JOURNAL

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Automated electrophysiology makes the pace for cardiac ion channel safety screening

(2011) Clemens Möller   Frontiers in Pharmacology

Reducing QT liability and proarrhythmic risk in drug discovery and development

(2010) Jean-Pierre Valentin   BRITISH JOURNAL OF PHARMACOLOGY

The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

(2010) B Rodriguez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium

(2009) Keith F. Decker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identification of I Kr Kinetics and Drug Binding in Native Myocytes

(2009) Qinlian Zhou et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitromodels of proarrhythmia

(2008) C L Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY

hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

(2008) John S. Mitcheson   CHEMICAL RESEARCH IN TOXICOLOGY

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

(2007) H Takemasa et al.   BRITISH JOURNAL OF PHARMACOLOGY

State dependent dissociation of HERG channel inhibitors

(2007) D Stork et al.   BRITISH JOURNAL OF PHARMACOLOGY

The canine virtual ventricular wall: A platform for dissecting pharmacological effects on propagation and arrhythmogenesis

(2007) Alan P. Benson et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY