Proton-Translocating Nicotinamide Nucleotide Transhydrogenase: A Structural Perspective

Association of adrenal insufficiency with insulin-dependent diabetes mellitus in a patient with inactivating mutations in nicotinamide nucleotide transhydrogenase: a phenocopy of the animal model

(2017) Rachel Scott et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox balance and the development of hypertension in mice

(2017) Igor Leskov et al.   Journal of the American Society of Hypertension

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

(2017) Jessica L. Thomaston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase

(2017) Pius S. Padayatti et al.   STRUCTURE

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

(2017) Laila R.B. Santos et al.   Molecular Metabolism

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

(2017) Hung-Yao Ho et al.   Redox Biology

NNTmutations: a cause of primary adrenal insufficiency, oxidative stress and extra-adrenal defects

(2016) Florence Roucher-Boulez et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Three-Dimensional Model of Human Nicotinamide Nucleotide Transhydrogenase (NNT) and Sequence-Structure Analysis of its Disease-Causing Variations

(2016) Louise A Metherell et al.   HUMAN MUTATION

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel

(2015) J. Baz Jackson et al.   FEBS LETTERS

Combined mineralocorticoid and glucocorticoid deficiency is caused by a novel founder nicotinamide nucleotide transhydrogenase mutation that alters mitochondrial morphology and increases oxidative stress

(2015) Ariella Weinberg-Shukron et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

(2015) Martin Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Division of labor in transhydrogenase by alternating proton translocation and hydride transfer

(2015) J. H. Leung et al.   SCIENCE

A comprehensive review of the lipid cubic phase orin mesomethod for crystallizing membrane and soluble proteins and complexes

(2015) Martin Caffrey   Acta Crystallographica Section F-Structural Biology Communications

Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

(2014) Debolina Ghosh et al.   AGING CELL

Nicotinamide Nucleotide Transhydrogenase (Nnt) Links the Substrate Requirement in Brain Mitochondria for Hydrogen Peroxide Removal to the Thioredoxin/Peroxiredoxin (Trx/Prx) System

(2014) Pamela Lopert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray crystal structure of voltage-gated proton channel

(2014) Kohei Takeshita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

(2013) Paulo A. Gameiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity

(2013) John T. Heiker et al.   Obesity

A review of the binding-change mechanism for proton-translocating transhydrogenase

(2012) J. Baz Jackson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency

(2012) Eirini Meimaridou et al.   NATURE GENETICS

Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H2O2—Implications for their role in disease, especially cancer

(2011) Simon P. J. Albracht et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Influenza M2 proton channels

(2010) Rafal M. Pielak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Proton-translocating transhydrogenase: an update of unsolved and controversial issues

(2008) Anders Pedersen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES