Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H2O2—Implications for their role in disease, especially cancer
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Title
Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H2O2—Implications for their role in disease, especially cancer
Authors
Keywords
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Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 43, Issue 5, Pages 541-564
Publisher
Springer Nature
Online
2011-09-01
DOI
10.1007/s10863-011-9381-4
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- (2010) Willem H. Koppenol et al. FREE RADICAL BIOLOGY AND MEDICINE
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