Purinergic Signaling in Mast Cell Degranulation and Asthma

Design and synthesis of novel xanthine derivatives as potent and selective A 2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases

(2017) Sujay Basu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells

(2017) Kazuki Yoshida et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

(2017) Manuel A.R. Ferreira et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

(2017) Kenneth A. Jacobson et al.   MEDICINAL RESEARCH REVIEWS

Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients

(2017) Ozen K. Basoglu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma

(2017) Sumito Isogai et al.   ALLERGOLOGY INTERNATIONAL

UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils

(2017) Manabu Nakano et al.   ALLERGOLOGY INTERNATIONAL

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

(2017) Antje Brüser et al.   Scientific Reports

Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases

(2016) Amir Pelleg et al.   CHEST

Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

(2016) Bruce N. Cronstein et al.   Nature Reviews Rheumatology

P2X7 receptors induce degranulation in human mast cells

(2016) Kathryn J. Wareham et al.   Purinergic Signalling

Nucleoside 5’-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation

(2016) Edyta Gendaszewska-Darmach et al.   Oncotarget

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

P2X7 receptor antagonist activity of the anti-allergic agent oxatomide

(2015) Kazuki Yoshida et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma

(2015) Brian R. Leaker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice

(2015) HONGXIA CHEN et al.   Molecular Medicine Reports

Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells

(2015) Hideaki Shirasaki et al.   ALLERGOLOGY INTERNATIONAL

Effect of A2B Adenosine Receptor Gene Ablation on Proinflammatory Adenosine Signaling in Mast Cells

(2014) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Effect of prasugrel in patients with asthma: results of PRINA, a randomized, double-blind, placebo-controlled, cross-over study

(2014) F. Lussana et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role of activated adenosine receptors in degranulation of human LAD2 mast cells

(2014) Chi Ting Leung et al.   Purinergic Signalling

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Regadenoson use in patients with chronic obstructive pulmonary disease: the state of current knowledge

(2014) Rami Doukky et al.   International Journal of Chronic Obstructive Pulmonary Disease

Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca2+Mobilization and Cell Proliferation

(2013) Ana Rita Pinheiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Adenosine Inhibits IgE-Dependent Degranulation of Human Skin Mast Cells

(2013) Gregorio Gomez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway

(2013) Luis M. Montaño et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mechanosensitive ATP Release Maintains Proper Mucus Hydration of Airways

(2013) B. Button et al.   Science Signaling

Regulation of Neutrophil Function by Adenosine

(2012) Kathryn E. Barletta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperresponsiveness to adenosine in sensitized Wistar rats over-expressing A1 receptor

(2012) Alessio Alfieri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of SSR161421, a novel orally active adenosine A3 receptor antagonist on pharmacology models

(2012) Endre G. Mikus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres

(2012) Letitia A. Weigand et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adenosine increases nasal mucociliary clearance rate in mice through A2Aand A2Badenosine receptors

(2012) Xiaoyang Hua et al.   LARYNGOSCOPE

The role of P2Y14 and other P2Y receptors in degranulation of human LAD2 mast cells

(2012) Zhan-Guo Gao et al.   Purinergic Signalling

Uridine adenosine tetraphosphate induces contraction of airway smooth muscle

(2011) Yu Gui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A1and A2Badenosine receptors

(2011) KH Yip et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biochemical Basis of Asthma Therapy

(2011) Peter J. Barnes   JOURNAL OF BIOLOGICAL CHEMISTRY

Allergic Asthma: Influence of Genetic and Environmental Factors

(2011) Anil B. Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disparity in FcεRI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine

(2011) Gregorio Gomez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Differential Inhibitory Effects of CysLT1 Receptor Antagonists on P2Y6 Receptor-Mediated Signaling and Ion Transport in Human Bronchial Epithelia

(2011) Wendy Ka-hoi Lau et al.   PLoS One

IL-4 Amplifies the Pro-Inflammatory Effect of Adenosine in Human Mast Cells by Changing Expression Levels of Adenosine Receptors

(2011) Xiaoyang Hua et al.   PLoS One

Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma

(2010) Dovenia S. Ponnoth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FcεRI β-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation responseviaFcεRI and adenosine receptors

(2010) Satoshi Nunomura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mast cell lines HMC-1 and LAD2 in comparison with mature human skin mast cells - drastically reduced levels of tryptase and chymase in mast cell lines

(2010) Sven Guhl et al.   EXPERIMENTAL DERMATOLOGY

Lack of the purinergic receptor P2X7results in resistance to contact hypersensitivity

(2010) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors

(2010) Edgar Flores-Soto et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

P2Y13 receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells

(2010) Zhan-Guo Gao et al.   PHARMACOLOGICAL RESEARCH

Attenuation of Chronic Pulmonary Inflammation in A2BAdenosine Receptor Knockout Mice

(2009) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

UDP-glucose acting at P2Y 14 receptors is a mediator of mast cell degranulation

(2009) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells

(2009) K Wareham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety of Binodenoson, a Selective Adenosine A 2A Receptor Agonist Vasodilator Pharmacological Stress Agent, in Healthy Subjects With Mild Intermittent Asthma

(2009) John J. Murray et al.   Circulation-Cardiovascular Imaging

ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells

(2009) B. Elena et al.   JOURNAL OF LEUKOCYTE BIOLOGY

P2 receptor-mediated signaling in mast cell biology

(2009) Elena Bulanova et al.   Purinergic Signalling

Regulation of adenosine 5′-triphosphate (ATP)-gated P2X4 receptors on tracheal smooth muscle cells

(2009) Miyuki Nagaoka et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Design and application of locally delivered agonists of the adenosine A2Areceptor

(2009) Simon Mantell et al.   Expert Review of Clinical Pharmacology

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation

(2008) Tyler H. Rork et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A2BAdenosine Receptors Regulate the Mucus Clearance Component of the Lung's Innate Defense System

(2008) Brett M. Rollins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Direct Development of Functionally Mature Tryptase/Chymase Double-Positive Connective Tissue-Type Mast Cells from Primate Embryonic Stem Cells

(2007) Feng Ma et al.   STEM CELLS