Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

Baicalin Ameliorates Experimental Liver Cholestasis in Mice by Modulation of Oxidative Stress, Inflammation, and NRF2 Transcription Factor

(2017) Kezhen Shen et al.   Oxidative Medicine and Cellular Longevity

Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines

(2016) Daniel R. Sappington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease

(2016) Muhammad Shahzad et al.   CURRENT DRUG TARGETS

Emerging drugs for the treatment of Primary Biliary Cholangitis

(2016) Ahmad H. Ali et al.   EXPERT OPINION ON EMERGING DRUGS

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

(2016) Chun Pang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulfated progesterone metabolites in the pathogenesis of intrahepatic cholestasis of pregnancy: Another loop in the ascending spiral of medical knowledge

(2016) Humberto Reyes   HEPATOLOGY

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

(2016) Siew Ying Wong et al.   Journal of Neuroinflammation

Global and Targeted Metabolomics Evidence of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats

(2016) Linjing Zhao et al.   JOURNAL OF PROTEOME RESEARCH

Induction of Nrf2/ARE-mediated cytoprotective genes by red ginseng oil through ASK1–MKK4/7–JNK and p38 MAPK signaling pathways in HepG2 cells

(2016) Min Ji Bak et al.   Journal of Ginseng Research

Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall.

(2016) Xiao Ma et al.   Frontiers in Pharmacology

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2016) Wenyan Sun et al.   Scientific Reports

Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease

(2015) Jae-Chul Jung et al.   BMC Complementary and Alternative Medicine

Bile Acids in Physiology, Pathology and Pharmacology

(2015) Jose J.G. Marin et al.   CURRENT DRUG METABOLISM

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Na+/H+exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury

(2015) Man Li et al.   HEPATOLOGY

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice

(2015) Jiaying Chen et al.   Oxidative Medicine and Cellular Longevity

Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis

(2015) Qiang Meng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation

(2015) Yong-Zhen Kang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model

(2015) Tai-Long Pan et al.   Scientific Reports

Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis

(2015) Zhi-Hao Zhang et al.   Scientific Reports

Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis

(2015) Gui-biao Zhang et al.   Chinese Medicine

Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction

(2015) Jin Chai et al.   PLoS One

Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice

(2014) Shi-Ying Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A systematic quality control method of Huangqi decoction: simultaneous determination of eleven flavonoids and seven triterpenoid saponins by UHPLC-MS

(2014) Hui-Long Luo et al.   Analytical Methods

Effect of drug transporter pharmacogenetics on cholestasis

(2014) Christoph G Dietrich et al.   Expert Opinion on Drug Metabolism & Toxicology

Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

(2014) Jing Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of combinations of Xiexin decoction constituents on diabetic nephropathy in rats

(2014) Jia-Sheng Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomics

(2013) Yin Huang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Nuclear receptors in bile acid metabolism

(2013) Tiangang Li et al.   DRUG METABOLISM REVIEWS

Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway

(2013) Xiaoming Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic cholestatic liver diseases: Clues from histopathology for pathogenesis

(2013) Marion J. Pollheimer et al.   MOLECULAR ASPECTS OF MEDICINE

Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice

(2013) Jie Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in ratsviaa p53-mediated pathway

(2013) Xiao-Ling Guo   WORLD JOURNAL OF GASTROENTEROLOGY

Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine

(2012) Jittima Weerachayaphorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis

(2012) Cheng Liu et al.   BMC Complementary and Alternative Medicine

Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-beta signaling pathway

(2012) Jin-Xing Du et al.   BMC Complementary and Alternative Medicine

The serum metabolomic study of intervention effects of the traditional Chinese medicine Shexiang Baoxin Pill and a multi-component medicine polypill in the treatment of myocardial infarction in rats

(2012) Li Xiang et al.   Molecular BioSystems

Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver

(2012) Kai Connie Wu et al.   PLoS One

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

Bile Acids Metabonomic Study on the CCl4- and α-Naphthylisothiocyanate-Induced Animal Models: Quantitative Analysis of 22 Bile Acids by Ultraperformance Liquid Chromatography−Mass Spectrometry

(2008) Li Yang et al.   CHEMICAL RESEARCH IN TOXICOLOGY