Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1

(2011) Qiuqiong Cheng et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers

(2011) Anwar Anwar-Mohamed et al.   TOXICOLOGY IN VITRO

Regulation of Human Carbonyl Reductase 3 (CBR3; SDR21C2) Expression by Nrf2 in Cultured Cancer Cells

(2010) Bettina Ebert et al.   BIOCHEMISTRY

Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver

(2010) Virpi Lämsä et al.   CHEMICAL RESEARCH IN TOXICOLOGY

SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity

(2010) Sandeep Singh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ascorbate Synthesis Pathway

(2010) Kenneth H. Gabbay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

(2010) Neil R. Kitteringham et al.   Journal of Proteomics

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

ChIPing the cistrome of PXR in mouse liver

(2010) Julia Yue Cui et al.   NUCLEIC ACIDS RESEARCH

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha

(2010) Hong Lu et al.   TOXICOLOGICAL SCIENCES

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

(2009) Scott A. Reisman et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

(2009) Ewa S. Pilka et al.   PLoS One

Increased Nrf2 Activation in Livers from Keap1-Knockdown Mice Increases Expression of Cytoprotective Genes that Detoxify Electrophiles more than those that Detoxify Reactive Oxygen Species

(2009) Scott A. Reisman et al.   TOXICOLOGICAL SCIENCES

Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase Activity

(2009) Scott A. Reisman et al.   TOXICOLOGICAL SCIENCES

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

(2009) Scott A. Reisman et al.   TOXICOLOGICAL SCIENCES

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

(2008) Kosuke Okada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver

(2008) N. Kassner et al.   DRUG METABOLISM AND DISPOSITION

The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification

(2008) Oleg A. Barski et al.   DRUG METABOLISM REVIEWS