The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function

Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells

(2017) Kalina Wiatr et al.   MOLECULAR NEUROBIOLOGY

Juvenile Huntington’s Disease: Diagnostic and Treatment Considerations for the Psychiatrist

(2017) Joanna Quigley   Current Psychiatry Reports

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Nuclear speckles are detention centers for transcripts containing expanded CAG repeats

(2016) Martyna O. Urbanek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA toxicity induced by expanded CAG repeats in Huntington's disease

(2016) Eulàlia Martí   BRAIN PATHOLOGY

iPSC-based drug screening for Huntington׳s disease

(2016) Ningzhe Zhang et al.   BRAIN RESEARCH

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting CAG repeat RNAs reduces Huntington’s disease phenotype independently of huntingtin levels

(2016) Laura Rué et al.   JOURNAL OF CLINICAL INVESTIGATION

How Wnt Signaling Builds the Brain: Bridging Development and Disease

(2016) Rivka Noelanders et al.   NEUROSCIENTIST

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome

(2016) Yue Li et al.   Science Translational Medicine

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease

(2016) Jana Miniarikova et al.   Molecular Therapy-Nucleic Acids

Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway

(2015) Wojciech J. Szlachcic et al.   Disease Models & Mechanisms

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Regulation of miRNA strand selection: follow the leader?

(2014) Hedda A. Meijer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

(2014) Andrew M. Tidball et al.   HUMAN MOLECULAR GENETICS

Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

(2014) M. Molina-Calavita et al.   JOURNAL OF NEUROSCIENCE

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

(2014) S. U. McKinstry et al.   JOURNAL OF NEUROSCIENCE

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

5′ isomiR variation is of functional and evolutionary importance

(2014) Geok Chin Tan et al.   NUCLEIC ACIDS RESEARCH

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

(2014) Douglas Macdonald et al.   PLoS One

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

(2013) Dagmar E. Ehrnhoefer et al.   HUMAN MOLECULAR GENETICS

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

(2013) M. Costanzo et al.   JOURNAL OF CELL SCIENCE

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

(2013) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Self-duplexing CUG repeats selectively inhibit mutant huntingtin expression

(2013) Agnieszka Fiszer et al.   NUCLEIC ACIDS RESEARCH

EZ spheres: A stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs

(2013) Allison D. Ebert et al.   Stem Cell Research

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

(2012) Mahru C. An et al.   Cell Stem Cell

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Exosomal miRNAs: Biological Properties and Therapeutic Potential

(2012) Guoku Hu et al.   Frontiers in Genetics

Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications

(2011) F. Cicchetti et al.   BRAIN

α-Synuclein modifies huntingtin aggregation in living cells

(2011) Federico Herrera et al.   FEBS LETTERS

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

(2011) Scott D. Olson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

(2009) Kosuke Yusa et al.   NATURE METHODS

Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease

(2009) A. E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

(2009) F. Cicchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving the photostability of bright monomeric orange and red fluorescent proteins

(2008) Nathan C Shaner et al.   NATURE METHODS