p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

(2014) Ramiro París et al.   CELL CYCLE

Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient

(2012) Jung-Il Chae et al.   BIOCHEMICAL JOURNAL

Cancer incidence in patients with polyglutamine diseases: a population-based study in Sweden

(2012) Jianguang Ji et al.   LANCET ONCOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease

(2011) Pengxiang She et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Small Changes, Big Impact

(2011) Dagmar E. Ehrnhoefer et al.   NEUROSCIENTIST

Regulation of miR-146a by RelA/NFkB and p53 in STHdhQ111/HdhQ111 Cells, a Cell Model of Huntington's Disease

(2011) Jayeeta Ghose et al.   PLoS One

Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease

(2011) Takuya Tamura et al.   PLoS One

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

(2011) Dagmar E. Ehrnhoefer et al.   PLoS One

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early and Late Events Induced by PolyQ-expanded Proteins

(2010) Alessandra Bertoni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin impairs Ku70-mediated DNA repair

(2010) Yasushi Enokido et al.   JOURNAL OF CELL BIOLOGY

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

(2010) R. K. Graham et al.   JOURNAL OF NEUROSCIENCE

Reduced gluconeogenesis and lactate clearance in Huntington's disease

(2010) Knud Josefsen et al.   NEUROBIOLOGY OF DISEASE

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

(2009) M. A. Pouladi et al.   BRAIN

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Regulation of the p53 transcriptional response by structurally diverse core promoters

(2009) J. M. Morachis et al.   GENES & DEVELOPMENT

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain

(2009) Franz Hagn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal morphology of peripheral cell tissues from patients with Huntington disease

(2009) Ferdinando Squitieri et al.   JOURNAL OF NEURAL TRANSMISSION

Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

(2009) D. Lau et al.   JOURNAL OF NEUROSCIENCE

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients

(2008) Sandra Almeida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

(2008) Simon C. Warby et al.   HUMAN MOLECULAR GENETICS

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

(2008) Jennifer Illuzzi et al.   JOURNAL OF NEUROSCIENCE RESEARCH