Journal
NEUROSCIENTIST
Volume 23, Issue 3, Pages 314-329Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858416667270
Keywords
Wnt/beta-catenin signaling; neural development; neurological disease
Categories
Funding
- Research Foundation - Flanders [G0D8716]
- Belgian Science Policy (Interuniversity Attraction Poles) [IAP7/07]
- Hercules Foundation, Flanders [AUGE/11/14]
- Concerted Research Actions from Ghent University [BOF/GOA/011]
- Research Foundation - Flanders (FWO-Vlaanderen)
Ask authors/readers for more resources
Wnt/beta-catenin signaling plays a crucial role throughout all stages of brain development and remains important in the adult brain. Accordingly, many neurological disorders have been linked to Wnt signaling. Defects in Wnt signaling during neural development can give rise to birth defects or lead to neurological dysfunction later in life. Developmental signaling events can also be hijacked in the adult and result in disease. Moreover, knowledge about the physiological role of Wnt signaling in the brain might lead to new therapeutic strategies for neurological diseases. Especially, the important role for Wnt signaling in neural differentiation of pluripotent stem cells has received much attention as this might provide a cure for neurodegenerative disorders. In this review, we summarize the versatile role of Wnt/beta-catenin signaling during neural development and discuss some recent studies linking Wnt signaling to neurological disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available