The yin and yang of α-synuclein-associated epigenetics in Parkinson’s disease

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

(2016) Frank Soldner et al.   NATURE

DNA methylation levels of α-synuclein intron 1 in the aging brain

(2015) Laura de Boni et al.   NEUROBIOLOGY OF AGING

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

(2015) Yan Kong et al.   PLoS One

Progress in unraveling the genetic etiology of Parkinson disease in a genomic era

(2015) Aline Verstraeten et al.   TRENDS IN GENETICS

α-Synuclein is Prone to Interaction with the GC-Box-Like Sequence In Vitro

(2014) Kai-Li Ma et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease

(2014) Savan Kabaria et al.   FEBS LETTERS

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease correlates with promoter methylation in the α-synuclein gene

(2014) Lasse Pihlstrøm et al.   MOVEMENT DISORDERS

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Increased striatal adenosine A2A receptor levels is an early event in Parkinson’s disease-related pathology and it is potentially regulated by miR-34b

(2014) Izaskun Villar-Menéndez et al.   NEUROBIOLOGY OF DISEASE

Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients

(2014) Yang Song et al.   NEUROSCIENCE LETTERS

miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway

(2014) Apostolia Fragkouli et al.   Frontiers in Cellular Neuroscience

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease

(2013) San-xi Ai et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy

(2013) Susana Gonçalves et al.   MOLECULAR NEUROBIOLOGY

A mir-153 binding site variation inSNCAin a patient with Parkinson's disease

(2013) Han-Joon Kim et al.   MOVEMENT DISORDERS

Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients

(2013) Yu-yan Tan et al.   PARKINSONISM & RELATED DISORDERS

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1

(2012) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

(2012) Alexander Kirilyuk et al.   PLoS One

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast

(2011) Xianpeng Liu et al.   HUMAN MOLECULAR GENETICS

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Negatively Regulates Protein Kinase C  Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

(2011) H. Jin et al.   JOURNAL OF NEUROSCIENCE

Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

(2011) L. de Boni et al.   NEUROMOLECULAR MEDICINE

Epigenetic Mechanisms in Cognition

(2011) Jeremy J. Day et al.   NEURON

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

(2011) Madalena Martins et al.   PLoS One

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models

(2010) Suvi Asikainen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

Hsp70 molecular chaperones and Parkinson's disease

(2009) Stephan N. Witt   BIOPOLYMERS

Methylation Status and Neurodegenerative Markers in Parkinson Disease

(2009) R. Obeid et al.   CLINICAL CHEMISTRY

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

(2009) Muralidhar et al.   Frontiers in Bioscience-Landmark

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease

(2009) Sotiria Sotiriou et al.   NEUROSCIENCE LETTERS

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

(2009) Rina Bandopadhyay et al.   TRENDS IN MOLECULAR MEDICINE

Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-Synuclein

(2008) Gaofeng Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The prodromal phase of sporadic Parkinson's disease: Does it exist and if so how long is it?

(2008) Christopher H. Hawkes   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

(2007) Julia Fuchs et al.   FASEB JOURNAL